Protein Alignment asp and aspm

DIOPT Version :10

• Sequence 1: NP_524488.3
• Gene: asp / 42946
• FlyBaseID: FBgn0000140
• Length: 1954
• Species: Drosophila melanogaster
• Sequence 2: XP_002932224.3
• Gene: aspm / 100379990
• XenbaseID: XB-GENE-877288
• Length: 3498
• Species: Xenopus tropicalis
• Alignment Length: 2295
• Identity: 552/2295 - (24%)
• Similarity: 919/2295 - (40%)
• Gaps: 697/2295 - (30%)

  Fly    23 EPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDDDIEVKVMKAIREEHNLSLEWMEHTVP 87
            ||.::.:..||....|.|..|.........:.:.||:.:...:.|.| :.:....|:...|..:|
 Frog    17 EPPLLSLTHFSRAPFVNFGCVRPGSVRSASLLLHNPNPEPASLAVFK-LPKNRGFSIVETESVIP 80

  Fly    88 ARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSKSNQPVKNPRKFPTVGKTLQLKS- 151
            ..:.:::.:.|:|:.|...:|.:..|.|...:.:.  :|..::..|.|..|   ....|:::||
 Frog    81 PFETITLTITWTPLEEGNVREIVTFIVNDVVKHQA--VLLGRAELPAKKKR---NTWNTIKMKSN 140

  Fly   152 PTG-------------AGKTMKSVVSAAVQQKKRMSAAAAPPSKQTWRVTAPSRPAA-WAHP--P 200
            |.|             ..||.||.|:      ||....      |..|..:|.:... .|||  .
 Frog   141 PIGPKVPVRRQKEVDMTSKTRKSQVT------KREKCG------QLERARSPLQSCENLAHPLCS 193

  Fly   201 PQAPLVEKNVYKTPQEEPVY-ISPQPRSLKENLSPMTPGNL-----LDVIDNLRFTPLTE--TRG 257
            | :|:.|..: .|....||. |||    :...|.|.|||:|     ..|:..:.::..||  |..
 Frog   194 P-SPMREIRL-STENRVPVLTISP----VSNELQPFTPGSLKRSKTYSVLCTVEYSESTEVATMS 252

  Fly   258 KGQATIFPDNLAAWPTPTLKGNVKSCANDMRPRRI----------TPD----------------- 295
            |....|..:.  .|   |||.: |.....|.|...          |||
 Frog   253 KYYTDIQVEE--EW---TLKAH-KLNKESMSPINSVHGHTHNVTHTPDFLMESALNSLLSPTAFC 311

  Fly   296 ------------DLEDQPATNKTFDVKHSETINISLDTLDCSRIDGQP----------------- 331
                        .|.::..|.:.|::..|:..:.:...:...|....|
 Frog   312 NQGPVQIDAHSSVLTEEQITQEKFNLASSKIPSPASPMVTPKRKFLSPNSFLSNSFVPEEYFSVG 376

  Fly   332 -HTPLNKTTTIVH----ATHTRALACIHEEEGP-------SPPRTPTKSAIHDLKRDIKLVGSPL 384
             |||:......|.    |:.:.:|.     .||       :.....:||:.....:|:::.|.|:
 Frog   377 EHTPILSPEQFVRENCLASQSESLV-----NGPMLSKSWQTASHNSSKSSSSSAIQDVQVSGGPV 436

  Fly   385 -RKYSESMKDLSLLSPQTKYAIQGSMPNL----------------------NEMKIRSIEQNRYY 426
             ::.|..:.::..|:.:..|.::.:..::                      ...|:::.::....
 Frog   437 EQEISSPIMEVPRLNSRLTYCVKKTKQSITFPVEHDQNIVKEPKKPCVFSATVTKLKAEDRKEKP 501

  Fly   427 QEQQIQIKAKDLNSSSSSEASLAGQQEFLFNHSEILAQ-----------------SSRFNLHEVG 474
            :.|.::.:.|..|::...::|:        ..|.|:.|                 |||
 Frog   502 KGQLLKSRRKLDNTTPEHKSSV--------TFSNIVLQDLPVISVPCPSDCSSDGSSR------- 551

  Fly   475 RKSVKGSPVKNPHKRRSHELSFSDAPSNESLYRNETVA------ISPP-------------KKQR 520
            ..|:..|.|.| .||:|.|...::|.....|   .||.      :|.|             |||.
 Frog   552 GTSICKSTVLN-RKRKSEEFLGTNAVMETEL---STVPQVKKTHLSKPDGSHVSYKEKLSQKKQV 612

  Fly   521 VEDTTLPRSAAPANASARSSSAHAWPHAQS-----KKFKLAQTMSLMKKPATPRKVRDTSIQPSV 580
            |...........|..|| .:..|....|||     .|.|:|.|....|:...         .|..
 Frog   613 VTQVLKSEKTLKARHSA-VNGKHTILKAQSVSVGPPKQKMAVTFKNSKRVVA---------VPQS 667

  Fly   581 KLYDSELYMQTCINPDPFAATTTIDPFLASTMYLDEQAVDRHQADFKKWLNALVSIPADLDADL- 644
            ||..::. .:|.|...|.       ||.|..|:.||:.:.:.:..|..|||.::: |.|.....
 Frog   668 KLVFTQT-SKTVIPRHPM-------PFAAKNMFYDERWMAKQERGFTWWLNFILT-PDDFAVKRD 723

  Fly   645 NNKIDVGKLFNEVRNKELVV---APTKEEQSMN-YLTKYRLETLRKAAVELFFSEQMRLPCSKVA 705
            ::|:....|.....|...|.   ||||||.|:. |.|:.:|..||::|..||.||.:.....::.
 Frog   724 SSKVQAATLILGSENAHKVSVPRAPTKEEVSLKAYTTRCKLNRLRRSACRLFTSEPVVKAILRLE 788

  Fly   706 VYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGLEVVFGEKIQMQSNRDIVGLSTFI 770
            |.:..|.|.:|.||:|..|:..::.||..||.:||||||:|||.:|||.|.::||.|:.||:.||
 Frog   789 VEIEAQRLLVRRDRHLWKDIGERQKILNWLLSYNPLWLRIGLETIFGELISLESNSDVTGLAVFI 853

  Fly   771 LNRLFRNK--CEEQRYSKAYTLTEE-YAETIKKHSLQKILFLLLFLDQAKQKRIVKHNPCLFVKK 832
            ||||..|.  ..|.|:.....|..: :.|.:.|.:|:|:|.|:.|||.|||.|::.|:||||.|.
 Frog   854 LNRLLWNPDIAAEYRHPSVPNLYRDGHEEALSKFTLKKLLLLIFFLDHAKQFRLIDHDPCLFWKD 918

  Fly   833 SPHKETKDILLRFSSELLANIGDITRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDGVRLTRV 897
            :.:|.:||:||.||.:.|:..||::|.|..||..:.|.||.|||||:|..||||||:.||||.|.
 Frog   919 AEYKTSKDLLLAFSRDFLSGEGDLSRHLGYLGLPVSHVQTPLDEFDFAVTNLAVDLQCGVRLVRT 983

  Fly   898 MEVILLRDDLTRQLRVPAISRLQRIFNVKLALGALGEANFQL----GGDIAAQDIVDGHREKTLS 958
            :|::.....|:::||||||||||::.||::||.||.:....|    |..|.::||||.|||:||:
 Frog   984 VELLAQSWSLSKKLRVPAISRLQKMHNVEVALQALTDRGVLLKDERGVSITSKDIVDRHRERTLA 1048

  Fly   959 LLWQLIYKFR------------------------------------SP------------KFHAA 975
            |||::::.|:                                    :|            |::..
 Frog  1049 LLWKIVFSFQVDVLLSTKQLKEEIQILKESYNTQKQLAALRSLANPAPTQTRESDQFEPEKYNER 1113

  Fly   976 ATVLQKWWR---------------------------RHW------LHVVIQRRIR---------- 997
            .::|.:|..                           .|:      |:.|.||..:
 Frog  1114 VSLLMEWVNAVCRFYSTKVQNFTVSFSDGRVFCYLVNHYHPSYLPLNAVCQRTTQTVECSQSGTA 1178

  Fly   998 ---------------------------HKELMRRH------------------------------ 1005
                                       :|||::..
 Frog  1179 MLNSSDSDNSLEVWPGVFDQGVTSSALYKELLKNEQTNFSLVHAAVADLGGIPAMVHHSDMSNTI 1243

  Fly  1006 ------------------------RAATVIQAVFRGHQMRKYVKLFK------------------ 1028
                                    |||.|||.|:|.::::...||.:
 Frog  1244 PDEKVVITFLSFLCARLLDLRKETRAARVIQTVWRNYRLKVEKKLLERKHKAARVIQRAVVQFLS 1308

  Fly  1029 ----TERTQAAIILQKFTRRYLAQKQLYQ---------SYHSIITIQRWWRAQQLGRQHRQRFVE 1080
                .:|:.:|.::||:.||||||:||.:         ..::.:.|||:|:    |...|:||:.
 Frog  1309 CCRLQKRSHSAAVIQKYFRRYLAQRQLKELKALKHKELQDNATLIIQRFWK----GYSARRRFII 1369

  Fly  1081 LREAAIFLQRIWRRRLFAKKLLAAAETARLQRSQKQ-QAAASYIQMQWRSYQLGRIQRQQFLRQR 1144
            ||.:||.:|...|.::             .|.|.|| |.|...:|...|::.||:.:||::|..:
 Frog  1370 LRHSAICMQARVRAKI-------------AQSSYKQIQQATVTLQSHMRAWLLGKKKRQEYLHIK 1421

  Fly  1145 DLIMFVQRRMRSKWSMLEQRKEFQQLKRAAINIQ---QRWRAKLSMR------------------ 1188
            ..::.:|... ::|...:|::..:    |.:.||   :||:|..||.
 Frog  1422 SSVIIIQHAF-TRWKRQKQKRHTE----AVLIIQKCYRRWKACKSMAQNMAAIKIQSVYRMHRER 1481

  Fly  1189 -----------------KCNAD---YLALRSSVLKVQAYRKATIQMRIDRNHYYSLRKNVICLQQ 1233
                             :|..|   :|..:.|:|.:|.|.:|..|.|:||..:..:|...|.:|.
 Frog  1482 QKFLDTKCKIIKIQSWFRCKKDREAFLMQKESILTLQKYYRAYKQGRLDRKKFLEMRSAAISIQA 1546

  Fly  1234 R------------------LRAIMKMREQRENYLRLRNASILVQKRYRMRQQMIQDR-------- 1272
            .                  |::..:||::::.|..::...:|:|...|..||..|.:
 Frog  1547 HYRGMRVRQLYYRIKAACVLQSYWRMRQEKKKYDHVKQLVVLLQSNVRKCQQQKQFKLMKRAACV 1611

  Fly  1273 -NAYLRT--------------RKCIINVQRRWR------ATLQMRR------------ERKNYLH 1304
             ..|.|:              |...:.:|..:|      |.||:|.            .||.:|.
 Frog  1612 IQTYYRSHRATKQAVHRFKQMRHAAVVIQSAFRRMQARKAKLQVRSAVKIQALSRSYFARKRFLE 1676

  Fly  1305 LQTTTKRIQIKFRAKREMKKQRAEFLQLKKVTLVVQKRRRALLQMRKERQEYLHLREVTIKLQ-- 1367
            ::..:.:||..||    |:::|..:..|:|.|..||::.||..||:|||:.|::::...||:|
 Frog  1677 IKRASIKIQSAFR----MRQRRVRYCALRKATFFVQQKFRAKKQMQKEREAYINMQVACIKVQAA 1737

  Fly  1368 ------RR----FH-----AQKSMRFMRAK--YRGTQAAVSCLQMHWRNHLLRKRERNSFLQLRQ 1415
                  ||    :|     .|...|..|.|  |:....|...:|.|:|.|.::..:|..||.::|
 Frog  1738 VRGHFVRREIQSWHKAATILQAEYRMWRQKKQYKLLYRAAIIIQEHYRAHKMQVHQRAYFLAIKQ 1802

  Fly  1416 AAITLQRRYR-------------ARLNM------IKQLKSYAQLKQAAITIQTRYRAKKAMQKQV 1461
            :|:.||..||             |.|::      .:..|:|.:::|:.:|||..||.|.:.:|:.
 Frog  1803 SAVRLQAAYRGYTVRKSVKTQRLAALHIQTAFRSYRIRKNYLRMRQSVVTIQRWYRCKTSGRKEQ 1867

  Fly  1462 VLYQKQREAIIKVQRRYRGNLEMRKQIEVYQKQRQAVIRLQKWWRSIRDMRLCKAGYRRIRL--- 1523
            ..|.:.:.|.:.||..|||.: .|||::|:   ..|.|.:|..:|..       |..::||.
 Frog  1868 KKYLEIQRATVTVQSAYRGWV-TRKQVKVW---NTAAICIQSAFRRY-------AAQKQIRTMKK 1921

  Fly  1524 SSLSIQRKWRATVQARRQREIFLSTIRKVRLMQAFIRATLLMRQQRREFEMKRRAAVVIQRRFRA 1588
            ::|:||:::||.:..||:||.:|......:.:||..|.    |..|::.|.:.::|.:||..:|
 Frog  1922 AALTIQQRYRAVLAGRRERERYLKLCMSAKRVQAMWRG----RAVRKDLERQHKSAALIQSFYR- 1981

  Fly  1589 RCAMLKARQDYQLIQSSVILVQRKFRANRSMKQARQEFVQLRTIAVHLQQKFRG----------- 1642
               |...:..|:.::.:..|:|..:||::..:..:..:::|:..|..||..:||
 Frog  1982 ---MHVCQTQYKAMRRASQLIQNFYRAHKLGQLQQFYYLRLKKCATVLQSAYRGWKVRRQMHSFH 2043

  Fly  1643 ----------------KR--------LMIE-----------QRNCFQLLRCSMPGFQARARGFMA 1672
                            ||        |.|:           ||..:..:|.|:...|:..|.||.
 Frog  2044 KAATTIQSAFRSFILHKRYHTLRTATLTIQRHYSAFLCARLQRTKYVRVRKSVIVLQSAFRSFMV 2108

  Fly  1673 RKRFQALMTPEMMDLIRQKRAAKVIQRYWRGYLIRRRQKHQGL--------LDIRKRIAQLRQEA 1729
            |||           ::|.:::|.|:||.:|..|..||.:.|.|        |....|..::|:..
 Frog  2109 RKR-----------ILRMQQSAIVVQRNYRALLTGRRVRKQYLELHRATCMLQAAWRGRKVRRNI 2162

  Fly  1730 KAVNSVRCKVQEAVRFLRGR 1749
            ||::.....:|...|.:|.|
 Frog  2163 KAMDKAATVIQSQYRMMRQR 2182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
asp	NP_524488.3	ASH	26..122	CDD:464865	18/95 (19%)
		CH_ASPM_rpt1	856..964	CDD:409072	57/111 (51%)
		IQCD	999..1028	CDD:467745	13/82 (16%)
		COG5022	<1076..>1419	CDD:227355	109/462 (24%)
		IQ	1689..1711	CDD:197470	9/21 (43%)
aspm	XP_002932224.3	ASH	19..115	CDD:464865	18/96 (19%)
		CH_ASPM_rpt1	942..1055	CDD:409072	57/112 (51%)
		CH_ASPM_rpt2	1113..1261	CDD:409073	10/147 (7%)
		COG5022	<1268..>1452	CDD:227355	55/205 (27%)
		COG5022	<1460..>1603	CDD:227355	27/142 (19%)
		COG5022	<1551..>1697	CDD:227355	28/149 (19%)
		COG5022	<1727..>1877	CDD:227355	38/149 (26%)
		COG5022	<1893..>2051	CDD:227355	40/175 (23%)
		COG5022	<2002..>2206	CDD:227355	43/192 (22%)
		COG5022	<2471..>2648	CDD:227355
		COG5022	<2603..>2780	CDD:227355
		COG5022	<2839..>3039	CDD:227355