DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and MFRP

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_113621.1 Gene:MFRP / 83552 HGNCID:18121 Length:579 Species:Homo sapiens


Alignment Length:315 Identity:92/315 - (29%)
Similarity:145/315 - (46%) Gaps:29/315 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   612 SYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFL 676
            |...|...|.:......:.:..|||::...:  |...||:|||.||.:..|||.:....:||:.|
Human   122 SQAAGTPKGQQESGVSPSPQSTCGGLLSGPR--GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQL 184

  Fly   677 NFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTV 741
            ......:|..    ..|.:|.|.: |...:..|.::   ||...||.:|:..|.|.:.|.||.:|
Human   185 KIEALSIESV----ASCLFDRLEL-SPEPEGPLLRV---CGRVPPPTLNTNASHLLVVFVSDSSV 241

  Fly   742 QRSGFVAKFVIDVDECSMNNGGCQH---RCRNTFGSYQCSCRNGYTLAENGHNCTETRCKF---- 799
            :..||.|.:    ...:...|.|.|   ||.........|..:|:....:|.:.|....||    
Human   242 EGFGFHAWY----QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCG 302

  Fly   800 -EITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSE 863
             .:|...|...:|:|.:.||..:.|.||.....||.|:|.||:|.:|:..||.:|||.:|:..|.
Human   303 GNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSS 367

  Fly   864 NS-STLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFV------SECG 911
            .: |.||.:||...|..:::|.:|:.::..||.|:...||.||::      :.||
Human   368 GAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808
CUB 388..474 CDD:214483
CUB 478..586 CDD:395345
FXa_inhibition 595..630 CDD:464251 3/17 (18%)
CUB 634..750 CDD:395345 37/115 (32%)
FXa_inhibition 757..792 CDD:464251 8/37 (22%)
CUB 797..906 CDD:395345 40/114 (35%)
CUB 910..1023 CDD:395345 2/2 (100%)
MFRPNP_113621.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 100..143 3/20 (15%)
CUB 144..252 CDD:238001 37/121 (31%)
LDLa 260..294 CDD:238060 8/33 (24%)
CUB 301..411 CDD:238001 38/109 (35%)
LDLa 421..454 CDD:238060 2/2 (100%)
CRD_FZ 466..579 CDD:143549
Blue background indicates that the domain is not in the aligned region.

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