Protein Alignment tld and Bmp1

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_112613.1
• Gene: Bmp1 / 83470
• RGDID: 620739
• Length: 990
• Species: Rattus norvegicus
• Alignment Length: 1049
• Identity: 424/1049 - (40%)
• Similarity: 616/1049 - (58%)
• Gaps: 104/1049 - (9%)

  Fly     7 MPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKE 71
            ||...:..|.:||   |.:::..|:..| ||.| .|.:...|...::.||         |:..|:
  Rat     1 MPGVARPPLPLLS---LPLLLLLLLPRA-GRPL-DLADYTYDLGEEDAPE---------LLNYKD 51

  Fly    72 P-------------KDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHS 123
            |             ::|:...: .:|.:..|::.:.:|..|||                   .:|
  Rat    52 PCKAAAFLGDIALDEEDLRAFR-VQQAAVLRQQTAQRSSIKAA-------------------GNS 96

  Fly   124 PTL-----NGQPIQ----------RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRH 173
            ..|     :|||.:          |.|||.|.|.||.|..||||:.|...|:|:.:|:|:|||||
  Rat    97 SALGRQSTSGQPQRGSRGRWRSRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRH 161

  Fly   174 WENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIG 238
            ||..||:.|:||..  ..:||.||.:.|||||::|:.|.|.|.||||:||:||||::|||||.||
  Rat   162 WEKHTCVTFLERTD--EDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIG 224

  Fly   239 FHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDT 303
            |.|||.|.|||:|:.|.:.||..||||||..:..:||:.....||.:||||||:|:||:..:|||
  Rat   225 FWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLDT 289

  Fly   304 ITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFE 368
            |.|.....|....:|||.|||:|||.||..||||.:||.|.|.::|:..||.:   .||
  Rat   290 IVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEY---PNG------ 345

  Fly   369 GSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSP 433
                          :.|.: :|.|||:.|.|||:||:...:.|..|..|..||:|:|||:|.|:|
  Rat   346 --------------YSAHM-HCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFWRKAP 395

  Fly   434 LVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYPM 497
            |..|.||....|.|.:..||:.:.:.:.:...| :||.|.:|.:||||:|  ||.. |.|||||.
  Rat   396 LRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVG-KGFFAVYEAICGGDVK--KDNGHIQSPNYPD 457

  Fly   498 DYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNI 562
            ||.|.|.|:|||...:...|.|.|||||:|:||.||||::|:|||:...|.||||:||.:.|.:|
  Rat   458 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSNLIGRYCGYEKPDDI 522

  Fly   563 KTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQAN 626
            |:.|::::::||||.|:.|.||:.....:||||...:. ||:..|:||||||:|.|..||||..:
  Rat   523 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPD 587

  Fly   627 GKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYT 691
            .:.||.||||.:  ||.|||:.||.:|..||.:|.|:|::|||..:.:.|.|..|:.||.    .
  Rat   588 KRRCEAACGGFL--TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN----D 646

  Fly   692 KCNYDYLIIYSKM-RDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVD 755
            .|.||::.:.|.: .|::|.  |.:||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.|
  Rat   647 VCKYDFVEVRSGLTADSKLH--GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKD 709

  Fly   756 ECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRN 820
            |||.:|||||..|.||||||:|.||:|:.|.:|.|:|.|..|:.::|::.|.:.|||:|:.||..
  Rat   710 ECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCEHKVTSTSGTITSPNWPDKYPSK 774

  Fly   821 IYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTN 885
            ..|.|...:..|||::|||.:.::||..||.||::.::|||...:..||.:||.::|..|:|:.|
  Rat   775 KECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGN 839

  Fly   886 EMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPES 950
            .||:...:|..:|||||:|:..:||||.:||...::..|||.::|...|...:.|:|.|.|:...
  Rat   840 RMFLRFYSDNSVQRKGFQASHSTECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY 904

  Fly   951 SVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESN 1014
            .|::.|..||:|....|.|||:|:. :||...... ||:||...|..:.|..|::|::|.:|::.
  Rat   905 GVELVFQTFEVEEETDCGYDYMELF-DGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTI 968

  Fly  1015 SLRGFAISF 1023
            |.:||.:.:
  Rat   969 SKKGFHLRY 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	108/200 (54%)
		CUB	388..474	CDD:214483	34/85 (40%)
		CUB	478..586	CDD:395345	58/108 (54%)
		FXa_inhibition	595..630	CDD:464251	16/35 (46%)
		CUB	634..750	CDD:395345	47/116 (41%)
		FXa_inhibition	757..792	CDD:464251	21/34 (62%)
		CUB	797..906	CDD:395345	43/108 (40%)
		CUB	910..1023	CDD:395345	39/113 (35%)
Bmp1	NP_112613.1	ZnMc_BMP1_TLD	125..324	CDD:239808	108/200 (54%)
		CUB	326..435	CDD:395345	44/133 (33%)
		CUB	439..548	CDD:395345	58/110 (53%)
		FXa_inhibition	559..591	CDD:464251	15/31 (48%)
		CUB	595..704	CDD:395345	47/116 (41%)
		FXa_inhibition	711..746	CDD:464251	21/34 (62%)
		CUB	751..860	CDD:395345	43/108 (40%)
		CUB	864..977	CDD:395345	39/113 (35%)