DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and Cubn

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_445784.3 Gene:Cubn / 80848 RGDID:68355 Length:3623 Species:Rattus norvegicus


Alignment Length:913 Identity:245/913 - (26%)
Similarity:375/913 - (41%) Gaps:195/913 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   229 IIHELGHTIGFHHEHARG-DRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAK 292
            ||...||.    :.:.|| :...|:|:.:|.::|.:..:|           .|.:..|....|.:
  Rat   942 IIESPGHP----NVYPRGVNCTWHVVVQRGQLIRLEFSSF-----------YLEFHYNCTNDYLE 991

  Fly   293 -NSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQA----NLLYKC----ASCGRTYQQNS 348
             ...:...:|.......|||.........|.:...|...|    ::.|:.    :.|...|..|.
  Rat   992 IYDTAAQTFLGRYCGKSIPPSLTSNSNSIKLIFVSDSALAHEGFSINYEAIDASSVCLYDYTDNF 1056

  Fly   349 GHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMS 413
            |.:.||:|   .|...|.:|                     |.:|||....:::.||.....|..
  Rat  1057 GMLSSPNF---PNNYPSNWE---------------------CIYRITVGLNQQIALHFTDFILED 1097

  Fly   414 --SDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFE- 475
              ...|. |::|||||.:..||||...||:|....|.:.::::.|.: ..:||...:||.|.:: 
  Rat  1098 YFGSQCV-DFVEIRDGGYETSPLVGIYCGSVLPPTIISHSNKLWLKF-KSDAALTAKGFSAYWDG 1160

  Fly   476 --VVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVE 538
              ..|||:| .|....:.||||||.|....||.||:.|.......|:||.|.||.|..|:.|::.
  Rat  1161 SSTGCGGNL-TTPTGVLTSPNYPMPYYHSSECYWRLEASHGSPFELEFQDFHLEHHPSCSLDYLA 1224

  Fly   539 IRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGF----------------SAA 587
            :.||..::||||.:.|||..|..|::..:.:.::..:|:..|..||                ::.
  Rat  1225 VFDGPTTNSRLIDKLCGDTTPAPIRSNKDVVLLKLRTDAGQQGRGFEINFRQRCDNVVIVNKTSG 1289

  Fly   588 LMLDVD---------ECKFTDHGCQHLCIN--TLG----SYQCGCRAGY-EL----QANGKTCED 632
            ::..::         .|.:|........:|  .||    ||. .|...| ||    |..|:.|.:
  Rat  1290 ILESINYPNPYDKNQRCNWTIQATTGNTVNYTFLGFDVESYM-NCSTDYVELYDGPQWMGRYCGN 1353

  Fly   633 ------------------------------------ACGGVVDATKSNGSLYSPSYPDVYPNSKQ 661
                                                .|||.:..|.  ||..||.||:.||::|:
  Rat  1354 NMPPPGATTGSQLHVLFHTDGINSGEKGFKMQWFTHGCGGEMSGTA--GSFSSPGYPNSYPHNKE 1416

  Fly   662 CVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHE---LPPV 723
            |:|.:...|..::.|....||:|    ::|.||||.|.||:.: |....:|...|...   .|..
  Rat  1417 CIWNIRVAPGSSIQLTIHDFDVE----YHTSCNYDSLEIYAGL-DFNSPRIAQLCSQSPSANPMQ 1476

  Fly   724 VNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAEN 788
            |:|..:.|.:.|.:|.|:...||.|.:       ....|||                .|.     
  Rat  1477 VSSTGNELAIRFKTDSTLNGRGFNASW-------RAVPGGC----------------GGI----- 1513

  Fly   789 GHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYD 853
                        |..|.|.:.|||||.:|..|..|.|..|....||:.|...||::|:...|:  
  Rat  1514 ------------IQLSRGEIHSPNYPNNYRANTECSWIIQVERHHRVLLNITDFDLEAPDSCL-- 1564

  Fly   854 YVAIYDGRSENSSTLGIYCGGRE-PYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRAT 917
              ..|||.|..::.:...||.:: |.::|||.|.:|:...:.:..|.:||:|.|..||||.: .|
  Rat  1565 --TTYDGSSSTNARVASVCGRQQPPNSIIASGNSLFVRFRSGSSSQNRGFRAEFREECGGRI-MT 1626

  Fly   918 NHSQTFYSHPRYGSRPYKRNMYCDWRIQADPE-SSVKIRFLHFEIEYSERCDYDYLEITEEGYSM 981
            :.|.|.:| |.| ...|..|..|.|.|:|.|. :.:.:.|.||:::.|..|..|::||.:.....
  Rat  1627 DSSDTIFS-PLY-PHNYLHNQNCSWIIEAQPPFNHITLSFTHFQLQNSTDCTRDFVEILDGNDYD 1689

  Fly   982 NTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGEDF---DAVTPF 1043
            ..:.||:||...|..|||..:.|.:||.||.:.|..||...:.|   ...|.|..|   |.:...
  Rat  1690 APVQGRYCGFSLPHPIISFGNALTVRFVTDSTRSFEGFRAIYSA---STSSCGGSFYTLDGIFNS 1751

  Fly  1044 PGY 1046
            |.|
  Rat  1752 PDY 1754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 22/118 (19%)
CUB 388..474 CDD:214483 28/87 (32%)
CUB 478..586 CDD:395345 41/123 (33%)
FXa_inhibition 595..630 CDD:464251 13/45 (29%)
CUB 634..750 CDD:395345 41/118 (35%)
FXa_inhibition 757..792 CDD:464251 4/34 (12%)
CUB 797..906 CDD:395345 36/109 (33%)
CUB 910..1023 CDD:395345 40/113 (35%)
CubnNP_445784.3 cubilin_NTD 38..132 CDD:412063
Interaction with AMN. /evidence=ECO:0000250|UniProtKB:O60494 39..46
EGF_CA 133..164 CDD:238011
EGF_CA 167..207 CDD:238011
EGF_CA 260..301 CDD:214542
EGF_3 306..344 CDD:463759
EGF_3 350..387 CDD:463759
EGF_CA 400..430 CDD:238011
EGF_CA 432..468 CDD:238011
CUB 474..585 CDD:238001
CUB 590..699 CDD:238001
CUB 708..815 CDD:238001
CUB 817..927 CDD:238001
CUB 932..1041 CDD:238001 22/113 (19%)
CUB 1048..1157 CDD:395345 37/134 (28%)
CUB 1165..1275 CDD:238001 41/110 (37%)
CUB 1278..1388 CDD:238001 14/110 (13%)
CUB 1391..1505 CDD:238001 41/127 (32%)
CUB 1510..1617 CDD:238001 38/143 (27%)
CUB 1620..1733 CDD:238001 40/115 (35%)
CUB 1738..1847 CDD:238001 5/17 (29%)
CUB 1852..1962 CDD:238001
CUB 1978..2088 CDD:238001
CUB 2092..2212 CDD:238001
CUB 2217..2333 CDD:238001
CUB 2336..2447 CDD:238001
CUB 2452..2564 CDD:238001
CUB 2570..2686 CDD:238001
CUB 2689..2800 CDD:238001
CUB 2805..2918 CDD:238001
CUB 2920..3034 CDD:238001
CUB 3037..3148 CDD:238001
CUB 3157..3273 CDD:238001
CUB 3278..3392 CDD:238001
CUB 3395..3506 CDD:238001
CUB 3511..3623 CDD:238001
Blue background indicates that the domain is not in the aligned region.

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