DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tld and CUBN

DIOPT Version :9

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_001072.2 Gene:CUBN / 8029 HGNCID:2548 Length:3623 Species:Homo sapiens


Alignment Length:989 Identity:254/989 - (25%)
Similarity:384/989 - (38%) Gaps:270/989 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 FTCIKFVERDPNLHANYIYFTVKNCGCC--SFLG-KNGNGRQPISIGRNCEKFGIIIHEL---GH 235
            |..|| .|....|...:.:|.:::...|  .||. .:|:......:||.|.  ..:.|||   .:
Human   501 FWVIK-TEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCG--SSLPHELLSSDN 562

  Fly   236 TIGFH--HEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKS 298
            .:.||  .||.|..             ||....::...||...:...||  .||         ||
Human   563 ALYFHLYSEHLRNG-------------RGFTVRWETQQPECGGILTGPY--GSI---------KS 603

  Fly   299 P-YLDTITPIGIPPG--------------------------------THLELGQRKRLSRGDIVQ 330
            | |     |...|||                                .:||:..      |.:.|
Human   604 PGY-----PGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRD------GPLYQ 657

  Fly   331 ANLLYK-CASCGRTYQQNSGHIVSPHFIYSGNGVL------------SEFEGSGDAGEDPSAE-- 380
            ..||.| |.:......|.:|.....|| :|.:.:.            |:....|:. .||..|  
Human   658 DPLLGKFCTTFSVPPLQTTGPFARIHF-HSDSQISDQGFHITYLTSPSDLRCGGNY-TDPEGELF 720

  Fly   381 -SEFDASLTN---CEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGN 441
             .|.....|:   |.:.:....||::.::...:.|....|.:|:|:|:|||    ..|:.::|||
Human   721 LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDG----ETLLGKVCGN 781

  Fly   442 VSGEVITTQTSRMLLNY-VNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKEC 505
            .:...|.:.|:.:.:.: ::.:..|.  .|:|.::|.||.:  ||.:..|.||.:|..|..::.|
Human   782 GTISHIKSITNSVWIRFKIDASVEKA--SFRAVYQVACGDE--LTGEGVIRSPFFPNVYPGERTC 842

  Fly   506 VWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIG-----RFCGDKLPPNIKTR 565
            .|.|..|.:..:.|.|..||:.....|..|:|||     ..|.::|     ::||..:|..|.:.
Human   843 RWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI-----GSSSILGSPENKKYCGTDIPSFITSV 902

  Fly   566 SNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTC 630
            .|.:|:.||..||.:..||.|         ||                               :.
Human   903 YNFLYVTFVKSSSTENHGFMA---------KF-------------------------------SA 927

  Fly   631 ED-ACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCN 694
            || |||.::  |:|.|::.||.:|:|||:...|.|.::..|||.:.|.|..|.||   ||| .|.
Human   928 EDLACGEIL--TESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLE---FHY-NCT 986

  Fly   695 YDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKF--VIDVDEC 757
            .|||.:|....:..|   |.|||..:||.:.|..:.|.|.|.:|..:...||:..:  :.....|
Human   987 NDYLEVYDTDSETSL---GRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048

  Fly   758 SM-------------------NNGGCQHR-----------------CRNTFGSY----------- 775
            ..                   ||..|.:|                 .....|:|           
Human  1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGG 1113

  Fly   776 ---------------------------------QCSCRNGYTLAENGHNCTETRCKFEITTSYGV 807
                                             |...|:|::...:|   :.|.|...:|||.|.
Human  1114 YEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDG---SSTGCGGNLTTSSGT 1175

  Fly   808 LQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYC 872
            ..|||||..|..:..|||..::..|...:|.|.||.:|.|..|..||:|:|||.|.||..|...|
Human  1176 FISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLC 1240

  Fly   873 GGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTF-----YSHPRYGSR 932
            |..:|..:.:|.:.||:.|.||.|.|.:||||.:...|...:..   :||:     ..:|    .
Human  1241 GDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV---NQTYGILESIGYP----N 1298

  Fly   933 PYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPII 997
            ||..|.:|:|.|:|...::|...||.|::|:...|..||||:.:....|    ||:||...||..
Human  1299 PYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQM----GRYCGVDLPPPG 1359

  Fly   998 ISNSDTLLLRFQTD 1011
            .:.|..|.:...||
Human  1360 STTSSKLQVLLLTD 1373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 44/202 (22%)
Astacin 144..339 CDD:279708 45/203 (22%)
CUB 388..474 CDD:214483 21/89 (24%)
CUB 478..586 CDD:278839 36/112 (32%)
FXa_inhibition 595..630 CDD:291342 2/34 (6%)
CUB 634..750 CDD:278839 43/115 (37%)
FXa_inhibition 757..792 CDD:291342 11/114 (10%)
CUB 797..906 CDD:278839 47/108 (44%)
CUB 910..1023 CDD:278839 32/107 (30%)
CUBNNP_001072.2 Interaction with AMN. /evidence=ECO:0000269|PubMed:30523278 42..49
EGF_CA 136..167 CDD:238011
EGF_CA 170..210 CDD:238011
EGF_CA 263..304 CDD:214542
EGF_3 309..347 CDD:289699
EGF_3 353..387 CDD:289699
EGF_CA 399..430 CDD:238011
EGF_CA 432..468 CDD:238011
CUB 474..585 CDD:238001 23/99 (23%)
CUB 590..699 CDD:238001 25/131 (19%)
CUB 708..815 CDD:238001 26/113 (23%)
CUB 817..927 CDD:238001 39/156 (25%)
CUB 932..1041 CDD:238001 43/117 (37%)
CUB 1048..1157 CDD:294042 10/108 (9%)
CUB 1165..1275 CDD:238001 47/109 (43%)
CUB 1282..1388 CDD:238001 31/103 (30%)
CUB 1391..1505 CDD:238001
CUB 1510..1617 CDD:238001
CUB 1620..1733 CDD:238001
CUB 1738..1847 CDD:238001
CUB 1859..1962 CDD:238001
CUB 1978..2088 CDD:278839
CUB 2092..2212 CDD:238001
CUB 2217..2333 CDD:238001
CUB 2336..2447 CDD:238001
CUB 2452..2564 CDD:238001
CUB 2570..2686 CDD:238001
CUB 2689..2800 CDD:238001
CUB 2805..2918 CDD:238001
CUB 2920..3034 CDD:238001
CUB 3037..3148 CDD:238001
CUB 3157..3273 CDD:238001
CUB 3278..3392 CDD:238001
CUB 3395..3506 CDD:238001
CUB 3511..3621 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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