DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and CUBN

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_001072.2 Gene:CUBN / 8029 HGNCID:2548 Length:3623 Species:Homo sapiens


Alignment Length:989 Identity:254/989 - (25%)
Similarity:384/989 - (38%) Gaps:270/989 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 FTCIKFVERDPNLHANYIYFTVKNCGCC--SFLG-KNGNGRQPISIGRNCEKFGIIIHEL---GH 235
            |..|| .|....|...:.:|.:::...|  .||. .:|:......:||.|.  ..:.|||   .:
Human   501 FWVIK-TEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCG--SSLPHELLSSDN 562

  Fly   236 TIGFH--HEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKS 298
            .:.||  .||.|..             ||....::...||...:...||  .||         ||
Human   563 ALYFHLYSEHLRNG-------------RGFTVRWETQQPECGGILTGPY--GSI---------KS 603

  Fly   299 P-YLDTITPIGIPPG--------------------------------THLELGQRKRLSRGDIVQ 330
            | |     |...|||                                .:||:..      |.:.|
Human   604 PGY-----PGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRD------GPLYQ 657

  Fly   331 ANLLYK-CASCGRTYQQNSGHIVSPHFIYSGNGVL------------SEFEGSGDAGEDPSAE-- 380
            ..||.| |.:......|.:|.....|| :|.:.:.            |:....|:. .||..|  
Human   658 DPLLGKFCTTFSVPPLQTTGPFARIHF-HSDSQISDQGFHITYLTSPSDLRCGGNY-TDPEGELF 720

  Fly   381 -SEFDASLTN---CEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGN 441
             .|.....|:   |.:.:....||::.::...:.|....|.:|:|:|:|||    ..|:.::|||
Human   721 LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDG----ETLLGKVCGN 781

  Fly   442 VSGEVITTQTSRMLLNY-VNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKEC 505
            .:...|.:.|:.:.:.: ::.:..|.  .|:|.::|.||.:  ||.:..|.||.:|..|..::.|
Human   782 GTISHIKSITNSVWIRFKIDASVEKA--SFRAVYQVACGDE--LTGEGVIRSPFFPNVYPGERTC 842

  Fly   506 VWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIG-----RFCGDKLPPNIKTR 565
            .|.|..|.:..:.|.|..||:.....|..|:|||     ..|.::|     ::||..:|..|.:.
Human   843 RWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI-----GSSSILGSPENKKYCGTDIPSFITSV 902

  Fly   566 SNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTC 630
            .|.:|:.||..||.:..||.|         ||                               :.
Human   903 YNFLYVTFVKSSSTENHGFMA---------KF-------------------------------SA 927

  Fly   631 ED-ACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCN 694
            || |||.::  |:|.|::.||.:|:|||:...|.|.::..|||.:.|.|..|.||   ||| .|.
Human   928 EDLACGEIL--TESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLE---FHY-NCT 986

  Fly   695 YDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKF--VIDVDEC 757
            .|||.:|....:..|   |.|||..:||.:.|..:.|.|.|.:|..:...||:..:  :.....|
Human   987 NDYLEVYDTDSETSL---GRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048

  Fly   758 SM-------------------NNGGCQHR-----------------CRNTFGSY----------- 775
            ..                   ||..|.:|                 .....|:|           
Human  1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGG 1113

  Fly   776 ---------------------------------QCSCRNGYTLAENGHNCTETRCKFEITTSYGV 807
                                             |...|:|::...:|   :.|.|...:|||.|.
Human  1114 YEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDG---SSTGCGGNLTTSSGT 1175

  Fly   808 LQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYC 872
            ..|||||..|..:..|||..::..|...:|.|.||.:|.|..|..||:|:|||.|.||..|...|
Human  1176 FISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLC 1240

  Fly   873 GGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTF-----YSHPRYGSR 932
            |..:|..:.:|.:.||:.|.||.|.|.:||||.:...|...:..   :||:     ..:|    .
Human  1241 GDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV---NQTYGILESIGYP----N 1298

  Fly   933 PYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPII 997
            ||..|.:|:|.|:|...::|...||.|::|:...|..||||:.:....|    ||:||...||..
Human  1299 PYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQM----GRYCGVDLPPPG 1359

  Fly   998 ISNSDTLLLRFQTD 1011
            .:.|..|.:...||
Human  1360 STTSSKLQVLLLTD 1373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 44/202 (22%)
CUB 388..474 CDD:214483 21/89 (24%)
CUB 478..586 CDD:395345 36/112 (32%)
FXa_inhibition 595..630 CDD:464251 2/34 (6%)
CUB 634..750 CDD:395345 43/115 (37%)
FXa_inhibition 757..792 CDD:464251 11/114 (10%)
CUB 797..906 CDD:395345 47/108 (44%)
CUB 910..1023 CDD:395345 32/107 (30%)
CUBNNP_001072.2 cubilin_NTD 32..135 CDD:412063
Interaction with AMN. /evidence=ECO:0000269|PubMed:30523278 42..49
EGF_CA 136..167 CDD:238011
EGF_CA 170..210 CDD:238011
EGF_CA 263..304 CDD:214542
EGF_3 309..347 CDD:463759
EGF_3 353..387 CDD:463759
EGF_CA 399..430 CDD:238011
EGF_CA 432..468 CDD:238011
CUB 474..585 CDD:238001 23/99 (23%)
CUB 590..699 CDD:238001 25/131 (19%)
CUB 708..815 CDD:238001 26/113 (23%)
CUB 817..927 CDD:238001 39/156 (25%)
CUB 932..1041 CDD:238001 43/117 (37%)
CUB 1048..1157 CDD:412131 10/108 (9%)
CUB 1165..1275 CDD:238001 47/109 (43%)
CUB 1282..1388 CDD:238001 31/103 (30%)
CUB 1391..1505 CDD:238001
CUB 1510..1617 CDD:238001
CUB 1620..1733 CDD:238001
CUB 1738..1847 CDD:238001
CUB 1859..1962 CDD:238001
CUB 1978..2088 CDD:395345
CUB 2092..2212 CDD:238001
CUB 2217..2333 CDD:238001
CUB 2336..2447 CDD:238001
CUB 2452..2564 CDD:238001
CUB 2570..2686 CDD:238001
CUB 2689..2800 CDD:238001
CUB 2805..2918 CDD:238001
CUB 2920..3034 CDD:238001
CUB 3037..3148 CDD:238001
CUB 3157..3273 CDD:238001
CUB 3278..3392 CDD:238001
CUB 3395..3506 CDD:238001
CUB 3511..3621 CDD:238001
Blue background indicates that the domain is not in the aligned region.

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