DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and pcolceb

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001122259.1	Gene:	pcolceb / 794872	ZFINID:	ZDB-GENE-080722-44	Length:	538	Species:	Danio rerio

Alignment Length:	278	Identity:	82/278 - (29%)
Similarity:	128/278 - (46%)	Gaps:	47/278 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 VCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRD 541
            :|||.| :|....:.|..:|..|..:.:|.|.||.|:.|.|.|:|:.|:||....|.||:|::.:
Zfish    34 LCGGHL-VTDSGFVASEGFPSHYKANSKCTWYITVPEGHVVMLQFRIFDLEADPTCRYDYVDVYN 97

  Fly   542 GNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAAL---MLDVDECKFTDHGCQ 603
            |:....:.:|||||...|..:.:.||.|.:...||||....||.|..   ...|||.:|
Zfish    98 GHSYTVQKLGRFCGTFRPGALISTSNTMMLEMASDSSTGGRGFLAYFSGGKPHVDEHQF------ 156

  Fly   604 HLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDV-YPNSKQCVWEVV 667
                                          |||.:  ||..||:.:|::|:. ||....|.|.:.
Zfish   157 ------------------------------CGGRL--TKPQGSVKTPNWPESDYPAGISCSWHIS 189

  Fly   668 APPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILR 732
            ...|..:.:.|...|||..    |.|.|||:.:::....:..::||.:||..:|..|.:..:.|.
Zfish   190 VESNMVIEVKFEKLDLELD----TYCRYDYVALFNGGETDDSRRIGKFCGDTVPDAVVTNGNELL 250

  Fly   733 LEFYSDRTVQRSGFVAKF 750
            :.|.||.:|..:||:|.:
Zfish   251 VHFVSDLSVTAAGFMAHY 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839	40/107 (37%)
		FXa_inhibition	595..630	CDD:291342	1/34 (3%)
		CUB	634..750	CDD:278839	37/116 (32%)
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
pcolceb	NP_001122259.1	CUB	35..145	CDD:238001	41/110 (37%)
		CUB	157..270	CDD:238001	37/118 (31%)
		Hc1	<334..398	CDD:284776
		NTR_like	416..538	CDD:295338
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910