DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and he1.3

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001091658.1	Gene:	he1.3 / 792176	ZFINID:	ZDB-GENE-040518-1	Length:	271	Species:	Danio rerio

Alignment Length:	198	Identity:	66/198 - (33%)
Similarity:	108/198 - (54%)	Gaps:	13/198 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 KERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKN-CGCCS 205
            |:.:.::..:||.:.:.:|....::.::||....|.|||:||.|.....    |.:::| .||.:
Zfish    77 KKNSSNFVEVPYIVSSEYSATEISVIQKAMSGIHNKTCIRFVPRISQTD----YISIENQDGCFA 137

  Fly   206 FLGKNGNGRQPISI-GRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDV 269
            |:|||| |:|.:|: .:.|....|:.|||.|.:||:|||.|.|||.:|.|:...|...:..||
Zfish   138 FIGKNG-GKQLVSLRKKGCVYHSIVQHELNHALGFYHEHVRSDRDSYITIHWEYIATNEIRNF-- 199

  Fly   270 LSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLL 334
             ..:..:.....||..|||||.|.:|:.....:|:||.   |...:.:|:.|.:|..||::.|::
Zfish   200 -MKKNTNSQNTTYDYGSIMHYGKTAFTTVKGKETMTPY---PDETVPIGKAKEMSDIDILRINMM 260

  Fly   335 YKC 337
            |.|
Zfish   261 YSC 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	66/198 (33%)
		Astacin	144..339	CDD:279708	65/196 (33%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
he1.3	NP_001091658.1	ZnMc	82..263	CDD:294052	64/191 (34%)
he1.3	NP_001091658.1	Astacin	86..264	CDD:279708	65/189 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900