DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and c6ast1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001036784.1	Gene:	c6ast1 / 751088	ZFINID:	ZDB-GENE-070621-1	Length:	260	Species:	Danio rerio

Alignment Length:	195	Identity:	76/195 - (38%)
Similarity:	109/195 - (55%)	Gaps:	23/195 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 IPYEIDTIFSGAHKALFKQAMRHWENFTCIKF----VERDPNLHANYIYFTVK-NCGCCSFLGKN 210
            :||.|...:|...|.:..|..|..|..||::|    .:||        |..:: |.||.||:|:.
Zfish    82 VPYIISDEYSTQEKDVIFQGFRSLEKSTCVRFRPRTTQRD--------YINIEPNSGCYSFVGRR 138

  Fly   211 GNGRQPISIGRN-CEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEE 274
             .|.|.:|:..: |.|..|:.|||.||:||||||.|.|||.|:.|...||:.|||.|||.:....
Zfish   139 -TGGQTVSLDHDGCIKLNIVQHELLHTLGFHHEHNRSDRDSHVQIVYKNIIPGQERNFDKIKTNN 202

  Fly   275 VDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCAS 339
            ::   ..||.:|:|||.:.:|||:... ||.||   |.:.:.:|:.||:|..||::.|.|| |:|
Zfish   203 LE---TAYDYSSVMHYGRFAFSKNKEA-TIVPI---PDSGVTIGRAKRMSSNDILRINRLY-CSS 259

Fly 340 339
Zfish 260 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	74/192 (39%)
		Astacin	144..339	CDD:279708	75/193 (39%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
c6ast1	NP_001036784.1	Astacin	71..259	CDD:279708	75/193 (39%)
c6ast1	NP_001036784.1	ZnMc_hatching_enzyme	77..257	CDD:239810	74/191 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910