DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and bmp1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_012814639.1	Gene:	bmp1 / 733960	XenbaseID:	XB-GENE-479191	Length:	975	Species:	Xenopus tropicalis

Alignment Length:	1035	Identity:	425/1035 - (41%)
Similarity:	590/1035 - (57%)	Gaps:	117/1035 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LWMMMFFLVDYAEGRRL----SQLPESECDFDFKE--QPEDFFGILDSSLVPPKEPKDDIYQLK- 80
            ||.::..::...:|:..    ..|.|.|...|:|:  :...|:|  |.:|     .::|:...|
Frog    11 LWALLVGMLLLGQGQEFLDYSYDLEEVEESIDYKDPCKAAAFWG--DIAL-----DEEDLANFKV 68

  Fly    81 --------------------TTRQHSGRR-RKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSP 124
                                ::|.|.||| ||:..:|
Frog    69 DRIVDLTKHTISTVSGAASNSSRPHKGRRMRKERRRS---------------------------- 105

  Fly   125 TLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNL 189
                    |.|||.|.|.||.|..|||||.|...|||:.:|:|:|||||||..||:.|:||..
Frog   106 --------RERRAATSRPERVWPDGVIPYVISGNFSGSQRAIFRQAMRHWEKHTCVTFLERTD-- 160

  Fly   190 HANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVI 254
            ..:||.||.:.|||||::|:.|.|.|.||||:||:||||::|||||.|||.|||.|.|||.|:.|
Frog   161 EDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSI 225

  Fly   255 NKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQ 319
            .:.||..||||||..:.||||:.....||.:||||||:|:||:..:||||.|.....|....:||
Frog   226 IRENIQPGQEYNFLKMEPEEVESLGETYDFDSIMHYARNTFSRGIFLDTILPKYDVNGVRPPIGQ 290

  Fly   320 RKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFD 384
            |.|||.|||.||..||||.:||.|.|.:.|:..||.|                    |:..|.:
Frog   291 RTRLSSGDIAQARKLYKCPACGETLQDSQGNFSSPGF--------------------PNGYSAY- 334

  Fly   385 ASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITT 449
               .:|.||::.|.|||:||:...|.|..|..|..||:|:|||:|.|:||..|.||:...|.|.:
Frog   335 ---MHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIEVRDGFWKKAPLRGRFCGDKIPEPIIS 396

  Fly   450 QTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYPMDYMPDKECVWRITAPD 513
            ..||:.:.:.:.:...| :||:|.:|.:||||:|  ||.. |.|||||.||.|:|.|||:::..|
Frog   397 TESRLWIEFRSSSNWVG-KGFQAVYEALCGGDVK--KDSGHIQSPNYPDDYRPNKACVWKLSVSD 458

  Fly   514 NHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSS 578
            ...|.:.|||||:|:||.||||::|||||:...|.|||||||...|.:||:.:||::|:||||.|
Frog   459 GFHVGVSFQSFEIERHDSCAYDYLEIRDGSSESSPLIGRFCGYDKPDDIKSSTNQLWIKFVSDGS 523

  Fly   579 VQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATK 642
            :.|.|||.....:||||...:: ||:..|:||||||:|.|..||||..:.|:||.||||.:  ||
Frog   524 INKAGFSLNYFKEVDECSRPNNGGCEQRCVNTLGSYKCACDPGYELGPDKKSCEAACGGFL--TK 586

  Fly   643 SNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKM-RD 706
            .|||:.||.:|..||.:|.|||::|||..:.:.|.|..|:.||.    ..|.||::.:.|.: .|
Frog   587 LNGSITSPGWPKEYPPNKNCVWQLVAPTQYRISLKFDQFETEGN----DVCKYDFVEVRSGLTSD 647

  Fly   707 NRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNT 771
            ::|.  |.:||.|||.|:.|:.:.:|:||.||.||.:.||.|.|..|.||||.:||||||.|.||
Frog   648 SKLH--GKFCGSELPAVITSQYNNMRIEFKSDNTVSKKGFQAHFFSDKDECSRDNGGCQHECTNT 710

  Fly   772 FGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQ 836
            .|||.|.||:|:||.||.|:|.|..|..::|.|.|.:.|||:|:.||....|.|......|||::
Frog   711 LGSYTCQCRSGFTLHENKHDCKEAGCDHKVTGSTGTISSPNWPDKYPSKKVCTWQITATAGHRVK 775

  Fly   837 LTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKG 901
            ||..:.::||||||:||:|.:|.|....|..|..:||.:.|..:|:..:.||:...:|..:|::|
Frog   776 LTVSEVDLESHQECLYDHVEVYSGHDAQSPVLTRFCGSKIPDPIISPGSTMFLKFVSDNSVQKRG 840

  Fly   902 FKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSER 966
            |.....|.|||.|.|...:|..|||.::|...:.....|.|.|.::....|::.|..||:|....
Frog   841 FLGELSSVCGGTLNAEVRTQDLYSHAKFGDDTHPSGTECLWHIVSEAGYGVELVFQSFELEEEPD 905

  Fly   967 CDYDYLEI---TEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISF 1023
            |.|||:|:   .:||...   .||:||...|..:.|..|.|.::|.:|::.:.:||.:.|
Frog   906 CGYDYMELYDGPDEGAPR---LGRYCGSGPPEEVYSAGDALTIKFHSDDTINKKGFHVRF 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	112/200 (56%)
		Astacin	144..339	CDD:279708	109/194 (56%)
		CUB	388..474	CDD:214483	34/85 (40%)
		CUB	478..586	CDD:278839	61/108 (56%)
		FXa_inhibition	595..630	CDD:291342	17/35 (49%)
		CUB	634..750	CDD:278839	49/116 (42%)
		FXa_inhibition	757..792	CDD:291342	23/34 (68%)
		CUB	797..906	CDD:278839	40/108 (37%)
		CUB	910..1023	CDD:278839	37/115 (32%)
bmp1	XP_012814639.1	ZnMc_BMP1_TLD	110..309	CDD:239808	112/200 (56%)
		CUB	311..420	CDD:366096	44/133 (33%)
		CUB	424..533	CDD:366096	62/110 (56%)
		FXa_inhibition	544..576	CDD:373209	16/31 (52%)
		CUB	580..689	CDD:366096	49/116 (42%)
		FXa_inhibition	696..731	CDD:373209	23/34 (68%)
		CUB	736..841	CDD:366096	38/104 (37%)
		CUB	849..962	CDD:366096	37/115 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1004	1.000	Inparanoid score	I296
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm9341
Panther	1	1.100	-	-	O	PTHR10127
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160