DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and TLL2

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_036597.1	Gene:	TLL2 / 7093	HGNCID:	11844	Length:	1015	Species:	Homo sapiens

Alignment Length:	1031	Identity:	438/1031 - (42%)
Similarity:	605/1031 - (58%)	Gaps:	68/1031 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SVGALWMMMFFLVDYAEGRRLSQLPESECDF---DFKEQPED-------------FFGIL----- 62
            ::|||..::..|........|.:.|::..|:   |.:|..|.             |:|.:
Human     6 ALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDED 70

  Fly    63 DSSLVPPKEPKDDIYQLKTTRQHS--GRRRKQSHKSQNKAALRLPPPFLWTDDAVD-VLQHS--- 121
            |..|....:.:|...|......||  |...:.|..|.:..|:.........|...: .|.||
Human    71 DLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGT 135

  Fly   122 -HSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVER 185
             |:......|  |.|||.|.|.||.|..|||||.|...|:|:.:|:|||||||||..||:.|:||
Human   136 LHAAAKTFSP--RVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIER 198

  Fly   186 DPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDK 250
            ..  ..::|.|:.:.|||||::|:.|.|.|.||||:||:||||:.|||||.:||.|||.|.|||:
Human   199 TD--EESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQ 261

  Fly   251 HIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHL 315
            |:.|.:.||..||||||..:...||......||.:||||||:|:||:..:||||.|.....|...
Human   262 HVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRP 326

  Fly   316 ELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAE 380
            .:|||.|||:|||.||..||||.:||.|.|..:|:..:|.|   .||.
Human   327 TIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGF---PNGY----------------- 371

  Fly   381 SEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGE 445
                .|.::|.|||:.|.|||::|:...:.|..|..|..||:|:|||||.|:||:.|.||:...|
Human   372 ----PSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPE 432

  Fly   446 VITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRIT 510
            .:.:..||:.:.:.:.:...| :||.|.:|..||||:.....| |.|||||.||.|.||||||||
Human   433 PLVSTDSRLWVEFRSSSNILG-KGFFAAYEATCGGDMNKDAGQ-IQSPNYPDDYRPSKECVWRIT 495

  Fly   511 APDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVS 575
            ..:...|.|.||:||:|:||.||||::|:|||...:|.|||.|||.:.|.::|:.||:::::|||
Human   496 VSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVS 560

  Fly   576 DSSVQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVD 639
            |.|:.|.||:|....:||||.:.|| ||:|.|:||||||:|.|..||||.|:.|.||.||||.:
Human   561 DGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFI- 624

  Fly   640 ATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKM 704
             ||.||::.||.:|..||.:|.|||:||||..:.:.|.|..|:|||.    ..|.||::.:.|.:
Human   625 -TKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGN----DVCKYDFVEVRSGL 684

  Fly   705 RDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCR 769
            ..: .|..|.:||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.|||:.:||||||.|.
Human   685 SPD-AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECV 748

  Fly   770 NTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHR 834
            ||||||.|.|||||.|.||||:|.|..|..:|::..|.|.|||:|:.||....|.|:..:..|||
Human   749 NTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHR 813

  Fly   835 IQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQR 899
            ::|||::||:|.||||.||::.:|||....:..||.:||.::|...:||.:.||:...:||.:||
Human   814 VKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQR 878

  Fly   900 KGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYS 964
            |||:|...:||||.|:|...::..|||.::|...|.....|||.|.|:....|::.|..||:|..
Human   879 KGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEE 943

  Fly   965 ERCDYDYLEITEEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGF 1019
            ..|.|||:| ..:||..:... |||||......|.|..|:|::||:||::.:.:||
Human   944 ADCGYDYME-AYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	107/200 (54%)
		Astacin	144..339	CDD:279708	104/194 (54%)
		CUB	388..474	CDD:214483	33/85 (39%)
		CUB	478..586	CDD:278839	58/107 (54%)
		FXa_inhibition	595..630	CDD:291342	21/35 (60%)
		CUB	634..750	CDD:278839	48/115 (42%)
		FXa_inhibition	757..792	CDD:291342	25/34 (74%)
		CUB	797..906	CDD:278839	47/108 (44%)
		CUB	910..1023	CDD:278839	42/111 (38%)
TLL2	NP_036597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..49		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..130		7/41 (17%)
		ZnMc_BMP1_TLD	150..349	CDD:239808	107/200 (54%)
		Astacin	157..350	CDD:279708	104/194 (54%)
		CUB	351..460	CDD:278839	43/133 (32%)
		CUB	464..573	CDD:278839	59/109 (54%)
		FXa_inhibition	584..616	CDD:291342	20/31 (65%)
		CUB	620..729	CDD:278839	48/115 (42%)
		FXa_inhibition	736..771	CDD:291342	25/34 (74%)
		CUB	776..885	CDD:278839	47/108 (44%)
		CUB	889..1002	CDD:278839	42/111 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8453
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830