DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and TLL1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_036596.3	Gene:	TLL1 / 7092	HGNCID:	11843	Length:	1013	Species:	Homo sapiens

Alignment Length:	916	Identity:	414/916 - (45%)
Similarity:	580/916 - (63%)	Gaps:	45/916 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 TLNGQ-PIQ--------RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCI 180
            |:.|: |:|        |..||.|.|.||.|..|||||.|...|:|:.:|:|||||||||..||:
Human   127 TVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCV 191

  Fly   181 KFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHAR 245
            .|:||..  ..:||.||.:.|||||::|:.|||.|.||||:||:||||::|||||.|||.|||.|
Human   192 TFIERSD--EESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTR 254

  Fly   246 GDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIP 310
            .|||.|:.|.:.||..||||||..:.|.||:.....||.:||||||:|:||:..:||||.|....
Human   255 PDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDD 319

  Fly   311 PGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGE 375
            .|....:|||.|||:|||.||..||:|.:||.|.|:::|::.||.|   .||.
Human   320 NGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGF---PNGY------------ 369

  Fly   376 DPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICG 440
                     .|.|:|.||::.|.|||::|:...:.|..|..|..||:|:|||||.||||:.|.||
Human   370 ---------PSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCG 425

  Fly   441 NVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKEC 505
            :...||:|:..|||.:.:.:.:...| :||.|.:|.:|||:::..:.| |.|||||.||.|.|||
Human   426 DKLPEVLTSTDSRMWIEFRSSSNWVG-KGFAAVYEAICGGEIRKNEGQ-IQSPNYPDDYRPMKEC 488

  Fly   506 VWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMY 570
            ||:||..:::.|.|.|||||:|:||.||||::|:|||...:|.|||||||...|.:|::.||.::
Human   489 VWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLW 553

  Fly   571 IRFVSDSSVQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDAC 634
            ::||||.:|.|.||:|....:.|||...|. ||:..|:||||||||.|..||||..:.::||.||
Human   554 MKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAAC 618

  Fly   635 GGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLI 699
            ||::  ||.||::.:|.:|..||.:|.|||:||||..:.:.:.|..|:|||...    |.|||:.
Human   619 GGLL--TKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEV----CKYDYVE 677

  Fly   700 IYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGC 764
            |:|.: .:..|..|.:||.|:|.|:.|:.:.:|:||.||.||.:.||.|.|..|.||||.:||||
Human   678 IWSGL-SSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGC 741

  Fly   765 QHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQT 829
            ||.|.||.|||.|.||||:.|.:|.|:|.|..|:.:|.:..|::.|||:|:.||....|.|....
Human   742 QHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISA 806

  Fly   830 VLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATD 894
            ..||||:|.|.:||:|.||||.||::.::||.:|.|..||..||.:.|..::|:.|:||:...:|
Human   807 TPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSD 871

  Fly   895 AGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHF 959
            |.:|||||:||..:||||.|:|.:..:..|||.::|...|...:.|:|.:.::..|.:::.|..|
Human   872 ASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTF 936

  Fly   960 EIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFM 1024
            |:|....|.|||:|:.:...|.....|||||...|..|.|..|::|:.|.||::.:.:||.|.:.
Human   937 EVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001

  Fly  1025 AVDPPE 1030
            ::..|:
Human  1002 SIRYPD 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	111/200 (56%)
		Astacin	144..339	CDD:279708	108/194 (56%)
		CUB	388..474	CDD:214483	37/85 (44%)
		CUB	478..586	CDD:278839	58/107 (54%)
		FXa_inhibition	595..630	CDD:291342	18/35 (51%)
		CUB	634..750	CDD:278839	48/115 (42%)
		FXa_inhibition	757..792	CDD:291342	22/34 (65%)
		CUB	797..906	CDD:278839	47/108 (44%)
		CUB	910..1023	CDD:278839	39/112 (35%)
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808	111/200 (56%)
		Astacin	155..348	CDD:279708	108/194 (56%)
		CUB	349..458	CDD:278839	48/133 (36%)
		CUB	462..571	CDD:278839	59/109 (54%)
		FXa_inhibition	582..614	CDD:291342	17/31 (55%)
		CUB	618..727	CDD:278839	48/115 (42%)
		FXa_inhibition	734..769	CDD:291342	22/34 (65%)
		CUB	774..883	CDD:278839	47/108 (44%)
		CUB	887..1000	CDD:278839	39/112 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159225
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8453
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.760