DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Tll1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001099551.1	Gene:	Tll1 / 678743	RGDID:	1306120	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	427/969 - (44%)
Similarity:	593/969 - (61%)	Gaps:	58/969 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQR 133
            ||: :..:|||....:..|...:|::.::.||     ||.|           |.....|..|
  Rat   102 PKK-RGALYQLIDRIRRIGSGLEQNNTTKGKA-----PPKL-----------SEQNEKNRVP--- 146

  Fly   134 RRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTV 198
              ||.|.|.||.|..|||||.|...|:|:.:|:|||||||||..||:.|.||..  ..:||.||.
  Rat   147 --RAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSD--EESYIVFTY 207

  Fly   199 KNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQ 263
            :.|||||::|:.|||.|.||||:||:||||::|||||.|||.|||.|.|||.|:.|.:.||..||
  Rat   208 RPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQ 272

  Fly   264 EYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDI 328
            ||||..:.|.||:.....||.:||||||:|:||:..:||||.|.....|....:|||.|||:|||
  Rat   273 EYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDI 337

  Fly   329 VQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWR 393
            .||..||:|.:||.|.|::||::.||.|   .||.                     .|.|:|.||
  Rat   338 AQARKLYRCPACGETLQESSGNLSSPGF---PNGY---------------------PSYTHCIWR 378

  Fly   394 ITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNY 458
            ::.|.|||::|:...:.|..|..|..||:|:|||||.||||:.|.||:....|:|:..|||.:.:
  Rat   379 VSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEF 443

  Fly   459 VNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQS 523
            .:.:...| :||.|.:|.:|||:::..:.| |.|||||.||.|.|||||:|...:.:.|.|.||:
  Rat   444 RSSSNWVG-KGFAAVYEAICGGEIRKNEGQ-IQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQA 506

  Fly   524 FELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAAL 588
            ||:|:||.||||.:|:||||..:|.|||||||...|.:|::.||.::::||||.:|.|.||:|..
  Rat   507 FEIERHDSCAYDHLEVRDGNSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571

  Fly   589 MLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSY 652
            ..:.|||...|. ||:..|:||||||||.|..||||..:.::||.||||::  ||.||::.:|.:
  Rat   572 FKEEDECAKADRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLL--TKLNGTITTPGW 634

  Fly   653 PDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCG 717
            |..||.:|.|||:|:||..:.:.:.|..|:|||...    |.|||:.|:|.: .:..|..|.:||
  Rat   635 PKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEV----CKYDYVEIWSGL-SSESKLHGKFCG 694

  Fly   718 HELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNG 782
            .::|.|:.|..:.:|:||.||.||.:.||.|.|..|.||||.:||||||.|.||.|||.|.||||
  Rat   695 ADVPEVITSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYTCQCRNG 759

  Fly   783 YTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESH 847
            :.|.||.|:|.|..|:.:|.:..|::.|||:|:.||....|.|....:.||||:|.|::||||.|
  Rat   760 FVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWAISAIPGHRIKLAFNEFEVEQH 824

  Fly   848 QECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGG 912
            |||.||::.|:||::|.|..||..||.:.|..::|:.||||:...:||.:|||||:||..:||||
  Rat   825 QECAYDHLEIFDGQTEKSPILGRLCGSKIPDPLMATGNEMFIRFISDASVQRKGFQATHSTECGG 889

  Fly   913 YLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEE 977
            .|:|....:..|||.::|...|...:.|:|.:.::..|.:::.|..||:|....|.|||:|:.:.
  Rat   890 RLKAERKPKDLYSHAQFGDNNYPGQLDCEWLLVSEQGSRLELSFQTFEVEEEADCGYDYVEVFDG 954

  Fly   978 GYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGED 1036
            ..|.....|||||...|..|.|..|..|:.|.||::.:.:||.|.:.::..||....|:
  Rat   955 LNSKAVGLGRFCGSGPPEEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAEN 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	111/200 (56%)
		Astacin	144..339	CDD:279708	108/194 (56%)
		CUB	388..474	CDD:214483	36/85 (42%)
		CUB	478..586	CDD:278839	57/107 (53%)
		FXa_inhibition	595..630	CDD:291342	18/35 (51%)
		CUB	634..750	CDD:278839	46/115 (40%)
		FXa_inhibition	757..792	CDD:291342	23/34 (68%)
		CUB	797..906	CDD:278839	50/108 (46%)
		CUB	910..1023	CDD:278839	39/112 (35%)
Tll1	NP_001099551.1	ZnMc_BMP1_TLD	148..347	CDD:239808	111/200 (56%)
		Astacin	155..348	CDD:279708	108/194 (56%)
		CUB	349..458	CDD:278839	48/133 (36%)
		CUB	462..571	CDD:278839	58/109 (53%)
		FXa_inhibition	582..614	CDD:291342	17/31 (55%)
		CUB	618..727	CDD:278839	46/115 (40%)
		FXa_inhibition	734..769	CDD:291342	23/34 (68%)
		CUB	774..883	CDD:278839	50/108 (46%)
		CUB	887..1000	CDD:278839	39/112 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353246
Domainoid	1	1.000	286	1.000	Domainoid score	I1530
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1013	1.000	Inparanoid score	I270
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8929
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810