DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and BMP1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens

Alignment Length:	1034	Identity:	421/1034 - (40%)
Similarity:	610/1034 - (58%)	Gaps:	94/1034 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEP------------ 72
            |..|.:::..|:....||     |....|:.:....||     ||..:..|:|
Human     4 VARLPLLLGLLLLPRPGR-----PLDLADYTYDLAEED-----DSEPLNYKDPCKAAAFLGDIAL 58

  Fly    73 -KDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSP---TLNGQPIQ- 132
             ::|:...: .:|....||..:.||..|||               |..::.:|   :.||||.:
Human    59 DEEDLRAFQ-VQQAVDLRRHTARKSSIKAA---------------VPGNTSTPSCQSTNGQPQRG 107

  Fly   133 ---------RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPN 188
                     |.|||.|.|.||.|..||||:.|...|:|:.:|:|:|||||||..||:.|:||..
Human   108 ACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTD- 171

  Fly   189 LHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIV 253
             ..:||.||.:.|||||::|:.|.|.|.||||:||:||||::|||||.:||.|||.|.|||:|:.
Human   172 -EDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVS 235

  Fly   254 INKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELG 318
            |.:.||..||||||..:.|:||:.....||.:||||||:|:||:..:||||.|.....|....:|
Human   236 IVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

  Fly   319 QRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEF 383
            ||.|||:|||.||..||||.:||.|.|.::|:..||.:   .||                    :
Human   301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEY---PNG--------------------Y 342

  Fly   384 DASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVIT 448
            .|.: :|.|||:.|.|||:||:...|.|..|..|..||:|:|||:|.|:||..|.||:...|.|.
Human   343 SAHM-HCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIV 406

  Fly   449 TQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYPMDYMPDKECVWRITAP 512
            :..||:.:.:.:.:...| :||.|.:|.:||||:|  ||.. |.|||||.||.|.|.|:|||...
Human   407 STDSRLWVEFRSSSNWVG-KGFFAVYEAICGGDVK--KDYGHIQSPNYPDDYRPSKVCIWRIQVS 468

  Fly   513 DNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDS 577
            :...|.|.|||||:|:||.||||::|:|||:...|.||||:||.:.|.:||:.|::::::||||.
Human   469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDG 533

  Fly   578 SVQKLGFSAALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDAT 641
            |:.|.||:.....:||||...:. ||:..|:||||||:|.|..||||..:.:.||.||||.:  |
Human   534 SINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFL--T 596

  Fly   642 KSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKM-R 705
            |.|||:.||.:|..||.:|.|:|::|||..:.:.|.|..|:.||.    ..|.||::.:.|.: .
Human   597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN----DVCKYDFVEVRSGLTA 657

  Fly   706 DNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRN 770
            |::|.  |.:||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.||||.:|||||..|.|
Human   658 DSKLH--GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN 720

  Fly   771 TFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRI 835
            |||||:|.||:|:.|.:|.|:|.|..|..::|::.|.:.|||:|:.||....|.|...:..|||:
Human   721 TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRV 785

  Fly   836 QLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRK 900
            :|||.:.::||..||.||::.::|||...:..||.:||.::|..|:|:.:.||:...:|..:|||
Human   786 KLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRK 850

  Fly   901 GFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSE 965
            ||:|:..:||||.:||...::..|||.::|...|...:.|:|.|.|:....|::.|..||:|...
Human   851 GFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEET 915

  Fly   966 RCDYDYLEITEEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISF 1023
            .|.|||:|:. :||...... ||:||...|..:.|..|::|::|.:|::.:.:||.:.:
Human   916 DCGYDYMELF-DGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	108/200 (54%)
		Astacin	144..339	CDD:279708	105/194 (54%)
		CUB	388..474	CDD:214483	35/85 (41%)
		CUB	478..586	CDD:278839	58/108 (54%)
		FXa_inhibition	595..630	CDD:291342	16/35 (46%)
		CUB	634..750	CDD:278839	47/116 (41%)
		FXa_inhibition	757..792	CDD:291342	21/34 (62%)
		CUB	797..906	CDD:278839	42/108 (39%)
		CUB	910..1023	CDD:278839	38/113 (34%)
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	108/200 (54%)
		Astacin	128..321	CDD:279708	105/194 (54%)
		CUB	322..431	CDD:278839	45/133 (34%)
		CUB	435..544	CDD:278839	58/110 (53%)
		FXa_inhibition	555..587	CDD:291342	15/31 (48%)
		CUB	591..700	CDD:278839	47/116 (41%)
		FXa_inhibition	707..742	CDD:291342	21/34 (62%)
		CUB	747..856	CDD:278839	42/108 (39%)
		CUB	860..973	CDD:278839	38/113 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8453
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830