Protein Alignment tld and astl2c

DIOPT Version :9

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_001037864.1
• Gene: astl2c / 594901
• XenbaseID: XB-GENE-6449741
• Length: 496
• Species: Xenopus tropicalis
• Alignment Length: 541
• Identity: 161/541 - (29%)
• Similarity: 259/541 - (47%)
• Gaps: 104/541 - (19%)

  Fly    67 VPPKEPKDDIYQLKTTRQHSGRRRKQ-----SHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTL 126
            ||..:  ||::. :..|.:.|:|...     :||. :::|:.. ...||..|:..::.
 Frog    36 VPDND--DDVFG-RILRANKGKRNFHVQGDIAHKF-SRSAINC-KECLWPKDSNGIVN------- 88

  Fly   127 NGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFV-ERDPNLH 190
                                    :||.|.:.:|....:|...||:.:...||::|: :.|.:
 Frog    89 ------------------------VPYTISSDYSQNEASLIMAAMQEFATLTCVQFIPQTDED-- 127

  Fly   191 ANYIYFTVKNCGCCSFLGKNGNGRQPISIGR-NCEKFGIIIHELGHTIGFHHEHARGDRDKHIVI 254
             :||.....: ||.|::|.|| |.|.:|:|: .|..:|:|.|||.|.:||.|||:|.|||.::.|
 Frog   128 -DYIAIQPLD-GCWSYIGVNG-GAQQVSLGKGGCIYYGVIQHELNHVLGFVHEHSRSDRDNYVHI 189

  Fly   255 NKGNIMRGQEYNFDVLSPEEV--------DLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPP 311
                       |:..:||:.:        |...|.||.:|:|||...|:|.:...:||.||   |
 Frog   190 -----------NYQYISPDNIAFFDKKDTDNLGLEYDYSSVMHYPGYSYSNTTGKNTIVPI---P 240

  Fly   312 GTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGED 376
            ..::.:|||..||..|:.:.|.||:|..|.:.:...||.:.|.::                .|..
 Frog   241 NANVPIGQRYGLSTLDVSKINRLYQCDVCSKLFTNASGTVTSANY----------------PGSY 289

  Fly   377 PSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSP-LVRRICG 440
            ||.        .:|.:.|...:|: |.:......:.||::|..||:.|.||....|| ::.:|||
 Frog   290 PSN--------ADCVFLIRVPSGQ-VSMTFNAFDVQSSNNCISDYITIYDGSSRSSPVMLGKICG 345

  Fly   441 NVSGEV--ITTQTSRMLLNYVNRNAAKGYRGFKARF-EVVCGGDLKLTKDQSIDSPNYPMDYMPD 502
              :|::  :.:.|:.||:.:|...|..| .||||.: .|.|||.. .|..::|.||.||..|.|:
 Frog   346 --TGQIPPLISSTNLMLVEFVTDGAIAG-TGFKASYTSVQCGGTY-FTPSRNITSPGYPNSYPPN 406

  Fly   503 KECVWRITAPDNH-QVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRS 566
            .:|.:.||||..: :|:|...||.||....|.||::::.||..::|.|:|.:||......:.||.
 Frog   407 MDCSYVITAPPPYKRVSLIMYSFTLESAPYCRYDYLQVYDGVSTNSPLMGTYCGTMSFSKVITRG 471

  Fly   567 NQMYIRFVSDSSVQKLGFSAA 587
            |.|.:.|.||.|.|..||.|:
 Frog   472 NSMLLHFSSDYSNQFQGFQAS 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	67/210 (32%)
		Astacin	144..339	CDD:279708	68/204 (33%)
		CUB	388..474	CDD:214483	28/88 (32%)
		CUB	478..586	CDD:278839	43/108 (40%)
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
astl2c	NP_001037864.1	ZnMc_hatching_enzyme	84..266	CDD:239810	67/231 (29%)
		Astacin	89..266	CDD:279708	67/195 (34%)
		CUB	270..380	CDD:238001	34/137 (25%)
		CUB	383..495	CDD:238001	44/111 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000