Protein Alignment tld and bmp1a

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_001035126.1
• Gene: bmp1a / 572452
• ZFINID: ZDB-GENE-060818-1
• Length: 986
• Species: Danio rerio
• Alignment Length: 927
• Identity: 410/927 - (44%)
• Similarity: 577/927 - (62%)
• Gaps: 50/927 - (5%)

  Fly   115 VDVLQHSHSPTLNGQP----------IQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQ 169
            |.:|.|:::.:|:.:.          ..|||||.|.|.||.|..|||||.|...|||:.:|:|:|
Zfish    78 VTILNHTNTGSLSNETSVNTTASSRGSHRRRRAATSRPERVWPEGVIPYVISGNFSGSQRAIFRQ 142

  Fly   170 AMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELG 234
            ||||||..||:.|:||  ....:||.||.:.|||||::|:.|.|.|.||||:||:||||::||||
Zfish   143 AMRHWEKHTCVTFIER--TTEESYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELG 205

  Fly   235 HTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSP 299
            |.|||.|||.|.|||:|:.|.:.||..||||||..:.|.|||.....||.:||||||:|:||:..
Zfish   206 HVIGFWHEHTRPDRDEHVSIIRDNIQPGQEYNFLKMEPGEVDSLGEVYDFDSIMHYARNTFSRGI 270

  Fly   300 YLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVL 364
            :||||.|.....|....:|||.|||:|||.||..||||..||.:.|::||:..||.:
Zfish   271 FLDTILPRYDVNGVRPPIGQRTRLSKGDIAQARKLYKCPRCGDSLQESSGNFSSPGY-------- 327

  Fly   365 SEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYW 429
                        |:..|.:    .:|.|||:.|.|||:||:...:.|..|..|..|::|||||||
Zfish   328 ------------PNGYSAY----MHCIWRISVTPGEKIILNFTSMDLYRSHLCWYDHVEIRDGYW 376

  Fly   430 HKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPN 494
            .|:||..|.||:...:.|.:..||:.:.:.:.:...| :||.|.:|.:|||::|....| |.|||
Zfish   377 RKAPLKGRFCGDKLPDPIISTDSRLWIEFRSSSNWVG-KGFSAVYEAICGGEVKKDNGQ-IQSPN 439

  Fly   495 YPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLP 559
            ||.||.|:|.|||:||....:.|.|.|||||:|:||.||||::|:||||...|.|:|||||...|
Zfish   440 YPDDYRPNKVCVWKITVAQGYHVGLTFQSFEIERHDNCAYDYLEVRDGNSESSPLLGRFCGYDKP 504

  Fly   560 PNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHG-CQHLCINTLGSYQCGCRAGYEL 623
            .:||:.|||::::||||.||.|.||:|....::|||...|:| |:..|:||||||:|.|..||||
Zfish   505 DDIKSSSNQLWMKFVSDGSVNKAGFAANFFKEMDECSRPDNGRCEQRCVNTLGSYKCACDPGYEL 569

  Fly   624 QANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEG--- 685
            .|:.::||.||||.:  ||.|||:.||.:|..||.:|.|:|::|||..:.:.|.|..|:.||
Zfish   570 AADKRSCEAACGGFI--TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRITLLFDVFETEGNDV 632

  Fly   686 -TRFHYTK--CNYDYLIIYSKM-RDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGF 746
             |||...:  |.||::.:.|.: .|:||.  |.:||.|.|..:.|:.:.:|:||.||.||.:.||
Zfish   633 STRFLPLRGVCKYDFVEVRSGLSADSRLH--GKFCGAEKPEAITSQYNNMRIEFKSDNTVSKKGF 695

  Fly   747 VAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSP 811
            .|:|..|.||||..||||||.|.||||||.|.||:|:.|.||.|:|.|..|...:.:..|.:.||
Zfish   696 KAQFFSDKDECSKENGGCQHECVNTFGSYSCQCRSGFVLHENKHDCKEAGCDHVVNSVSGTITSP 760

  Fly   812 NYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGRE 876
            |:|:.||....|.|...|..||||::.|::.::|.|.||.||::.|||||...:.:||.|||.::
Zfish   761 NWPDKYPSKKACTWALSTTPGHRIKIAFNEIDMEPHLECAYDHIEIYDGRDSKAQSLGRYCGTKK 825

  Fly   877 PYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCD 941
            |..:|::.|:||:...:|..:|:|||:|:..:||||.|:|...::..|||.::|...|.....|.
Zfish   826 PQPIISTGNKMFIRFFSDNSVQKKGFEASHTAECGGRLKAEVKTKDLYSHAQFGDNNYPGASDCQ 890

  Fly   942 WRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLL 1006
            |.|.|:....|::.|..||||....|.|||:|:.:...:.:...||:||...|..|.|..|::::
Zfish   891 WVITAEKGYGVELIFQTFEIEEEADCGYDYMELFDGADTKSPRLGRYCGSGPPEEIYSAGDSIVI 955

  Fly  1007 RFQTDESNSLRGFAISF 1023
            :|.:|::.:.:||.:.:
Zfish   956 KFHSDDTINKKGFHVRY 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	112/200 (56%)
		CUB	388..474	CDD:214483	34/85 (40%)
		CUB	478..586	CDD:395345	61/107 (57%)
		FXa_inhibition	595..630	CDD:464251	18/35 (51%)
		CUB	634..750	CDD:395345	50/122 (41%)
		FXa_inhibition	757..792	CDD:464251	23/34 (68%)
		CUB	797..906	CDD:395345	43/108 (40%)
		CUB	910..1023	CDD:395345	37/112 (33%)
bmp1a	NP_001035126.1	ZnMc_BMP1_TLD	112..309	CDD:239808	111/198 (56%)
		CUB	311..420	CDD:395345	43/133 (32%)
		CUB	424..533	CDD:395345	62/109 (57%)
		FXa_inhibition	544..576	CDD:464251	17/31 (55%)
		CUB	580..699	CDD:395345	50/122 (41%)
		FXa_inhibition	706..741	CDD:464251	23/34 (68%)
		CUB	746..855	CDD:395345	43/108 (40%)
		CUB	859..972	CDD:395345	37/112 (33%)