DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and pcolcea

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001025352.2	Gene:	pcolcea / 563867	ZFINID:	ZDB-GENE-041014-370	Length:	479	Species:	Danio rerio

Alignment Length:	277	Identity:	82/277 - (29%)
Similarity:	130/277 - (46%)	Gaps:	47/277 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 CGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDG 542
            ||||| :.....:.|..:|..|.|:.:|.|.||.|:.:.|.|.|:.|:||....|.||:|::.:|
Zfish    35 CGGDL-VGDSGFVGSEGFPSFYKPNSKCTWYITVPEGNVVMLSFRIFDLEADPLCRYDYVDVYNG 98

  Fly   543 NHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAAL---MLDVDECKFTDHGCQH 604
            :.:..:.:|||||...|..:.:.||.|.:..||||.....||.|..   ...|||.:|
Zfish    99 HSNMVQKLGRFCGTFRPGALISTSNTMMVEMVSDSGTGGRGFVAYFNGGKPHVDEHQF------- 156

  Fly   605 LCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDV-YPNSKQCVWEVVA 668
                                         |||.:  |||.|::.:|::|:. ||....|.|.:..
Zfish   157 -----------------------------CGGKL--TKSQGTIKTPNWPEKNYPPGISCSWLITV 190

  Fly   669 PPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRL 733
            .|...:.:.|..||||..    |.|.:||:..::....:..::||.|||:..|..:.:..::|.:
Zfish   191 EPEMVIEVKFDKFDLESD----TYCRFDYVAFFNGGEKDDSRRIGKYCGYTAPQNIVTNSNVLLV 251

  Fly   734 EFYSDRTVQRSGFVAKF 750
            :|.||.:|...||:|.:
Zfish   252 QFVSDLSVTSDGFMASY 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839	40/107 (37%)
		FXa_inhibition	595..630	CDD:291342	1/34 (3%)
		CUB	634..750	CDD:278839	37/116 (32%)
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
pcolcea	NP_001025352.2	CUB	35..144	CDD:238001	41/109 (38%)
		CUB	157..270	CDD:238001	37/118 (31%)
		NTR_PCOLCE	355..479	CDD:239631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910