DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and bmp1b

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_005155463.1	Gene:	bmp1b / 559877	ZFINID:	ZDB-GENE-060818-2	Length:	970	Species:	Danio rerio

Alignment Length:	992	Identity:	414/992 - (41%)
Similarity:	594/992 - (59%)	Gaps:	71/992 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLK------TTRQHSGRRRKQS--HKSQNK 99
            |....:.|:|:..:....:.|.:|     .::|:..||      |..:.||..:..|  ..|.|:
Zfish    26 PGESDEVDYKDPCKAVAFLGDIAL-----DEEDLRFLKAHYMHATENESSGSSKPDSVNRSSANR 85

  Fly   100 AALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHK 164
            .|                   ...|.|..|.|.|||||.|.|.||.|..|:|||.|...|:|:.:
Zfish    86 NA-------------------KDEPVLANQSILRRRRAATARPERVWPNGIIPYIISGNFTGSQR 131

  Fly   165 ALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGII 229
            |:|||||||||..||:.||||  ::..:||.||::.||||||:|:.|.|.|.||||:||:||||:
Zfish   132 AIFKQAMRHWEKHTCVTFVER--SVEESYIVFTLRPCGCCSFVGRRGGGPQAISIGKNCDKFGIV 194

  Fly   230 IHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNS 294
            :|||||.|||.|||.|.|||:|:.|.:.||..||||||..:.|::||.....||.:||||||:|:
Zfish   195 VHELGHVIGFWHEHTRPDRDEHVDIFRENIQPGQEYNFIKMEPDDVDSLGEVYDFDSIMHYARNT 259

  Fly   295 FSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYS 359
            ||:..||||:.|.....|....:|||.|||:|||.||..||:|..||.:.|.::|:..||.|
Zfish   260 FSRGIYLDTMLPKYDVDGVRPPIGQRTRLSKGDIAQARKLYRCPRCGESLQDSAGNFSSPGF--- 321

  Fly   360 GNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEI 424
            .||.                     |:..:|.|||:.|.|||::|:...:.|..|:.|..||:|:
Zfish   322 PNGY---------------------AAYLHCIWRISVTPGEKIVLNFTSMDLYRSNLCWYDYVEV 365

  Fly   425 RDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS 489
            ||||...:||..||||:...|.|.:..|.:.:.:.:.:...| :||.|.:|.:|||:::....|
Zfish   366 RDGYGRSAPLKGRICGDQLPEAIVSTDSELWIEFRSTSNWVG-KGFSAVYEAICGGEVRRDSGQ- 428

  Fly   490 IDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFC 554
            |:|||||.||.|:|.|:|:|..|:...|.|.|||||:||||.||||::|:|||:...|.|:||||
Zfish   429 IESPNYPDDYRPNKACIWKIVVPEGFHVGLVFQSFEIEKHDNCAYDYLEVRDGDSESSPLLGRFC 493

  Fly   555 GDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHG-CQHLCINTLGSYQCGCR 618
            |.:.|.:.|:.|||::::||||.||.|.||:|....::|||...|:. |:..|||||||:.|.|.
Zfish   494 GYEKPDDFKSSSNQLWMKFVSDGSVNKAGFAANFFKEIDECSRPDNAHCEQRCINTLGSFHCACD 558

  Fly   619 AGYELQANGKTC-EDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFD 682
            .|:||..:.::| ..||||.:  :|.|||..||.:|..||.:|.|||:::||..:.:.|.|..|:
Zfish   559 PGFELAPDRRSCAAAACGGFI--SKLNGSFTSPGWPQEYPPNKNCVWQLIAPVQYRITLLFDAFE 621

  Fly   683 LEGTRFHYTKCNYDYLIIYSKM-RDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGF 746
            :||.    ..|.|||:.::|.: .|.:|.  |.:||.|.|..:.|:.:.:.:||.||.||.:.||
Zfish   622 MEGN----DVCKYDYVEVHSGLSADGKLH--GKFCGTEKPEAITSQLNSMSVEFKSDNTVSKRGF 680

  Fly   747 VAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSP 811
            .|:|..|:||||..||||||.|.||||||.|.||:|:.|..|.|:|.|..|...||:..|::.||
Zfish   681 KAQFFSDMDECSRENGGCQHECVNTFGSYSCQCRSGFVLHSNKHDCKEVGCDQAITSVSGLITSP 745

  Fly   812 NYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGRE 876
            |:|:.||....|.|...|..||||:|.|.:.::|:||||.||::.||||::..::::|.:||.::
Zfish   746 NWPDKYPSKKACTWTLSTTPGHRIKLAFEEIDMEAHQECAYDHLEIYDGQNGRATSVGRFCGSKK 810

  Fly   877 PYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCD 941
            |..||:|:|.||:...:|..:|::||||:..:||||.|:|...::..|||.::|...|.....|.
Zfish   811 PSPVISSSNTMFLRFFSDNSVQKRGFKASHSAECGGSLKAEIKTKDLYSHAQFGDNNYPGASDCQ 875

  Fly   942 WRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLL 1006
            |.|.|:....|::.|..||||....|.|||:|:.:.|.......||:||...|..|.|..|.:::
Zfish   876 WVISAEKGYGVELIFHTFEIEEEADCGYDYVELFDGGDVKAPRLGRYCGSGPPEEIYSAGDAIVI 940

  Fly  1007 RFQTDESNSLRGFAISF 1023
            :|.:|::.:.:||.:.:
Zfish   941 KFHSDDTINKKGFHVRY 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	111/200 (56%)
		Astacin	144..339	CDD:279708	108/194 (56%)
		CUB	388..474	CDD:214483	32/85 (38%)
		CUB	478..586	CDD:278839	58/107 (54%)
		FXa_inhibition	595..630	CDD:291342	15/35 (43%)
		CUB	634..750	CDD:278839	45/116 (39%)
		FXa_inhibition	757..792	CDD:291342	22/34 (65%)
		CUB	797..906	CDD:278839	46/108 (43%)
		CUB	910..1023	CDD:278839	38/112 (34%)
bmp1b	XP_005155463.1	ZnMc_BMP1_TLD	109..303	CDD:239808	108/195 (55%)
		Astacin	111..303	CDD:279708	107/193 (55%)
		CUB	305..414	CDD:278839	42/133 (32%)
		CUB	418..527	CDD:278839	59/109 (54%)
		EGF_CA	530..570	CDD:214542	17/39 (44%)
		CUB	575..684	CDD:278839	45/116 (39%)
		FXa_inhibition	691..726	CDD:291342	22/34 (65%)
		CUB	731..840	CDD:278839	46/108 (43%)
		CUB	844..957	CDD:278839	38/112 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1534
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	990	1.000	Inparanoid score	I294
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm6442
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880