Protein Alignment tld and tll2l

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_001016661.1
• Gene: tll2l / 549415
• XenbaseID: XB-GENE-478930
• Length: 500
• Species: Xenopus tropicalis
• Alignment Length: 453
• Identity: 146/453 - (32%)
• Similarity: 221/453 - (48%)
• Gaps: 45/453 - (9%)

  Fly   146 WDYG-----VIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCS 205
            ||..     .:|:.:...::.:..||...||:.:|..||:.||   |..:...:.......||.|
 Frog    81 WDISSNGKVPVPFTVSPGYTKSQLALITAAMQEFETLTCVDFV---PKTNEKNVININNGNGCWS 142

  Fly   206 FLGKNGNGRQPISIGR-NCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDV 269
            ::|::| |.|.:|:.: :|...|||.|||.|.:||.|||.|.|||:::.:.|.||:.....|||:
 Frog   143 YIGRSG-GVQQVSLSKQSCMVKGIIQHELNHVLGFVHEHVRSDRDQYVNVVKKNILPDSLGNFDI 206

  Fly   270 LSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLL 334
            .....:.   ||||..|:|||.:|:||.||:|.|:.   ..|...:::|||..|:..||.:.|.|
 Frog   207 AVTNNLG---LPYDYYSVMHYPRNAFSISPFLPTLI---TKPDPTIQIGQRYGLTNLDIAKINKL 265

  Fly   335 YKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNG 399
            |.|..|.......:|.:.||.:                    |||..:    ..||.|.|...:.
 Frog   266 YNCDVCSTLLSDVNGTLFSPSY--------------------PSAYPD----NANCVWLIRIPSN 306

  Fly   400 EKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSP-LVRRICGNVSGEVITTQTSRMLLNYVNRNA 463
            : |.:......|.:|.:|..||::|.||.....| |:.:.||::....||..::.|||.:|: |.
 Frog   307 Q-VSVQFIAFSLQTSQNCVSDYVKIYDGATRSDPVLLDKACGSLLLPPITASSNLMLLEFVS-NE 369

  Fly   464 AKGYRGFKARFEVV-CGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELE 527
            .....||:|.:..| |||.. .::..|..||.||:.|.|...|:|.|.||...::.|.....|:|
 Frog   370 GNTMTGFEATYSTVSCGGTY-TSQSNSFSSPGYPVAYPPLTTCIWSIYAPVGFKIVLTINKIEVE 433

  Fly   528 KHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALML 590
            ....|.||.:.|.||.::.:.::...||:...||..:|...|.:.|.||.||||.||.|:..|
 Frog   434 YGLLCMYDSLTIYDGYNTTAPILRCACGNTAVPNQISRGRSMLLVFSSDISVQKKGFQASYTL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	69/197 (35%)
		CUB	388..474	CDD:214483	27/86 (31%)
		CUB	478..586	CDD:395345	39/107 (36%)
		FXa_inhibition	595..630	CDD:464251
		CUB	634..750	CDD:395345
		FXa_inhibition	757..792	CDD:464251
		CUB	797..906	CDD:395345
		CUB	910..1023	CDD:395345
tll2l	NP_001016661.1	ZnMc_hatching_enzyme	86..268	CDD:239810	67/191 (35%)
		CUB	272..382	CDD:238001	33/135 (24%)
		CUB	385..495	CDD:238001	40/110 (36%)