DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and tll1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001008039.1	Gene:	tll1 / 493401	XenbaseID:	XB-GENE-479941	Length:	495	Species:	Xenopus tropicalis

Alignment Length:	496	Identity:	152/496 - (30%)
Similarity:	239/496 - (48%)	Gaps:	63/496 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LWTDDAVDVLQHSHSPTLNGQ-PIQRRRRAVTVRKERTW-----DYGVIPYEIDTIFSGAHKALF 167
            |:| |.:...|.|....::|. .::..|.|:.. .|..|     .:..:||.:.:.:|.......
Frog    42 LYT-DIMKANQKSKKLRIHGDIALKTDRNAINC-TECLWPKSSDGFVYVPYTVSSDYSQDEVNAI 104

  Fly   168 KQAMRHWENFTCIKFV----ERDPNLHANYIYFTVKNC-GCCSFLGKNGNGRQPISIGRN-CEKF 226
            ..||:.:|..||::|.    |.|        |..:::. ||.|::|..| |.|.:|:.:. |...
Frog   105 TTAMKEYEGLTCVQFTPWTGEDD--------YLAIQSLDGCWSYIGYYG-GSQAVSLLKGFCAYN 160

  Fly   227 GIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYA 291
            |.:.|||.|.:||:|||.|.|||.::.|....|......|||.:|...:.   :.||.:||:|||
Frog   161 GGVQHELNHALGFYHEHNRSDRDDYVTIMYQYISPENIGNFDKISTNNLG---VDYDYSSILHYA 222

  Fly   292 KNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHF 356
            .|:||.:...:||.|   .|..::.:||...||..|:::.|.||.|..|.......:|.:.|.::
Frog   223 GNAFSNTSGQNTIVP---HPNPNVPIGQSYGLSNLDVLKINRLYGCDECSTLLSAPNGTLTSTNY 284

  Fly   357 --IYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQ 419
              .|..|                          .||.|.| .|..::|.|.....::..|..||.
Frog   285 PSNYQNN--------------------------ANCVWLI-RTPSDQVTLSFNAFNVQKSQSCTS 322

  Fly   420 DYLEIRDGYWHKSPLV-RRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVV-CGGDL 482
            ||:.:.||....:|:: .:.||.....|:...|:|||:.:|..:|... .||||.:..| |||..
Frog   323 DYIRVYDGATTSAPMILDKTCGTGPLPVMIASTNRMLVEFVTDSAITA-PGFKASYSTVQCGGTF 386

  Fly   483 KLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDS 547
             .|..:::.:||||..|.|:.:|.:.||||.:::|||...:|.:||...|.||::||.|||...:
Frog   387 -YTPSRNVTTPNYPKSYPPNLDCQFIITAPTSYKVALNINNFFVEKSANCQYDYLEIYDGNSMSA 450

  Fly   548 RLIG-RFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAA 587
            ..|| |:|..::...:.:....|.:||.||:|||..||:|:
Frog   451 PKIGSRYCSYQVFNVMVSSGRSMLLRFHSDASVQMYGFTAS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	66/211 (31%)
		Astacin	144..339	CDD:279708	65/205 (32%)
		CUB	388..474	CDD:214483	28/86 (33%)
		CUB	478..586	CDD:278839	43/108 (40%)
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
tll1	NP_001008039.1	ZnMc_hatching_enzyme	83..265	CDD:239810	63/196 (32%)
		CUB	269..379	CDD:238001	32/137 (23%)
		CUB	382..494	CDD:238001	44/111 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1004	1.000	Inparanoid score	I296
OMA	1	1.010	-	-		QHG48714
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm9341
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070