Protein Alignment tld and tll1

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_571085.1
• Gene: tll1 / 474335
• ZFINID: ZDB-GENE-041020-1
• Length: 1022
• Species: Danio rerio
• Alignment Length: 960
• Identity: 411/960 - (42%)
• Similarity: 577/960 - (60%)
• Gaps: 82/960 - (8%)

  Fly    69 PKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQR 133
            |.....|:..:||     |.||..|.::...   |:|
Zfish   127 PVNSSKDVSSIKT-----GIRRVNSARNVKS---RVP---------------------------- 155

  Fly   134 RRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTV 198
              ||.|.|.|:.|..|||||.|...|:|:.:|:.||||||||..||:.|:|:..  ..:||.||.
Zfish   156 --RAATSRAEKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTD--EESYIVFTY 216

  Fly   199 KNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQ 263
            :.|||||::|:.|||.|.||||:||:||||::|||||.|||.|||.|.|||.|:.|.:.||..||
Zfish   217 RPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQ 281

  Fly   264 EYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDI 328
            ||||..:.|.:|:....|||.:||||||:|:||:..:||||.|.....|....:|||.|||:|||
Zfish   282 EYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIGQRTRLSKGDI 346

  Fly   329 VQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWR 393
            .||..||:|.:||.|.|.:.|:..||.:   .||.                     .|.|:|.||
Zfish   347 SQAKKLYRCPACGETLQDSVGNFSSPGY---PNGY---------------------PSYTHCVWR 387

  Fly   394 ITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNY 458
            |:.|.|||::|:...:.|..|..|..||:|:|||||.|:||:.|.||:...||:.:..|||.:.:
Zfish   388 ISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEF 452

  Fly   459 VNRNAAKGYRGFKARFEVVCGGDLKLTKDQ-SIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQ 522
            .:.:...| :||.|.:|.:|||:  ::||. .|.|||||.||.|.||||||||..:.:.|.|.||
Zfish   453 RSSSNWVG-KGFAAVYEAICGGE--ISKDSGQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQ 514

  Fly   523 SFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAA 587
            .||:|:||.||||::|:|||...:|.|||||||...|.:|::.||.::::||||.:|.|.||:|.
Zfish   515 VFEIERHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKAGFAAN 579

  Fly   588 LMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPS 651
            ...:.|||...|: ||:..|:|||||::|.|..||||..:.|:||.||||::  ||.||::.:|.
Zfish   580 FFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLL--TKLNGTITTPG 642

  Fly   652 YPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKM-RDNRLKKIGIY 715
            :|..||.:|.|||:||||..:.:.:.|..|:|||...    |.|||:.:.|.: .|::|.  |.|
Zfish   643 WPKEYPPNKNCVWQVVAPTQYRISMQFEAFELEGNEV----CKYDYVEVRSGLSSDSKLH--GKY 701

  Fly   716 CGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCR 780
            ||.|:|.|:.|:.:.:|:||.||.||.:.||.|.|..|.||||.:||||||.|.||.|||.|.||
Zfish   702 CGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTIGSYVCQCR 766

  Fly   781 NGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVE 845
            ||:.|.||.|:|.|..|:.:|.::.|.:.|||:|:.||....|.|......|||::::|::||:|
Zfish   767 NGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPGHRVKISFNEFEIE 831

  Fly   846 SHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSEC 910
            .||||.||::..:||.|:.:..|...||.:.|..:|::.|:|::...:||.:|||||:||..:||
Zfish   832 QHQECAYDHLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMYLRFISDASVQRKGFQATHSTEC 896

  Fly   911 GGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEIT 975
            ||.|:|....:..|||.::|...|..:..|:|.|.|:....:::.|..||:|....|.|||:|:
Zfish   897 GGRLKAEARQKNLYSHAQFGDNNYPGHTDCEWLIVAESGYGIELTFTTFEVEEEADCGYDYIEL- 960

  Fly   976 EEGYSMNTIH--GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISF 1023
            .:||.... |  |||||......:.|..|.:|:.|.:|::.|.:||.|.:
Zfish   961 YDGYDTGA-HKIGRFCGSGPREELYSAGDAVLIHFHSDDTISKKGFHIRY 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	108/200 (54%)
		CUB	388..474	CDD:214483	36/85 (42%)
		CUB	478..586	CDD:395345	59/108 (55%)
		FXa_inhibition	595..630	CDD:464251	17/35 (49%)
		CUB	634..750	CDD:395345	49/116 (42%)
		FXa_inhibition	757..792	CDD:464251	23/34 (68%)
		CUB	797..906	CDD:395345	42/108 (39%)
		CUB	910..1023	CDD:395345	40/114 (35%)
tll1	NP_571085.1	ZnMc_BMP1_TLD	157..356	CDD:239808	108/200 (54%)
		CUB	358..467	CDD:395345	46/133 (35%)
		CUB	471..580	CDD:395345	60/110 (55%)
		FXa_inhibition	591..623	CDD:464251	16/31 (52%)
		CUB	627..736	CDD:395345	49/116 (42%)
		FXa_inhibition	743..778	CDD:464251	23/34 (68%)
		CUB	783..892	CDD:395345	42/108 (39%)
		CUB	896..1009	CDD:395345	40/114 (35%)