DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and tll1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_571085.1	Gene:	tll1 / 474335	ZFINID:	ZDB-GENE-041020-1	Length:	1022	Species:	Danio rerio

Alignment Length:	960	Identity:	411/960 - (42%)
Similarity:	577/960 - (60%)	Gaps:	82/960 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQR 133
            |.....|:..:||     |.||..|.::...   |:|
Zfish   127 PVNSSKDVSSIKT-----GIRRVNSARNVKS---RVP---------------------------- 155

  Fly   134 RRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTV 198
              ||.|.|.|:.|..|||||.|...|:|:.:|:.||||||||..||:.|:|:..  ..:||.||.
Zfish   156 --RAATSRAEKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTD--EESYIVFTY 216

  Fly   199 KNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQ 263
            :.|||||::|:.|||.|.||||:||:||||::|||||.|||.|||.|.|||.|:.|.:.||..||
Zfish   217 RPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQ 281

  Fly   264 EYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDI 328
            ||||..:.|.:|:....|||.:||||||:|:||:..:||||.|.....|....:|||.|||:|||
Zfish   282 EYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIGQRTRLSKGDI 346

  Fly   329 VQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWR 393
            .||..||:|.:||.|.|.:.|:..||.:   .||.                     .|.|:|.||
Zfish   347 SQAKKLYRCPACGETLQDSVGNFSSPGY---PNGY---------------------PSYTHCVWR 387

  Fly   394 ITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNY 458
            |:.|.|||::|:...:.|..|..|..||:|:|||||.|:||:.|.||:...||:.:..|||.:.:
Zfish   388 ISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEF 452

  Fly   459 VNRNAAKGYRGFKARFEVVCGGDLKLTKDQ-SIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQ 522
            .:.:...| :||.|.:|.:|||:  ::||. .|.|||||.||.|.||||||||..:.:.|.|.||
Zfish   453 RSSSNWVG-KGFAAVYEAICGGE--ISKDSGQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQ 514

  Fly   523 SFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAA 587
            .||:|:||.||||::|:|||...:|.|||||||...|.:|::.||.::::||||.:|.|.||:|.
Zfish   515 VFEIERHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKAGFAAN 579

  Fly   588 LMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPS 651
            ...:.|||...|: ||:..|:|||||::|.|..||||..:.|:||.||||::  ||.||::.:|.
Zfish   580 FFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLL--TKLNGTITTPG 642

  Fly   652 YPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKM-RDNRLKKIGIY 715
            :|..||.:|.|||:||||..:.:.:.|..|:|||...    |.|||:.:.|.: .|::|.  |.|
Zfish   643 WPKEYPPNKNCVWQVVAPTQYRISMQFEAFELEGNEV----CKYDYVEVRSGLSSDSKLH--GKY 701

  Fly   716 CGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCR 780
            ||.|:|.|:.|:.:.:|:||.||.||.:.||.|.|..|.||||.:||||||.|.||.|||.|.||
Zfish   702 CGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTIGSYVCQCR 766

  Fly   781 NGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVE 845
            ||:.|.||.|:|.|..|:.:|.::.|.:.|||:|:.||....|.|......|||::::|::||:|
Zfish   767 NGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPGHRVKISFNEFEIE 831

  Fly   846 SHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSEC 910
            .||||.||::..:||.|:.:..|...||.:.|..:|::.|:|::...:||.:|||||:||..:||
Zfish   832 QHQECAYDHLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMYLRFISDASVQRKGFQATHSTEC 896

  Fly   911 GGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEIT 975
            ||.|:|....:..|||.::|...|..:..|:|.|.|:....:::.|..||:|....|.|||:|:
Zfish   897 GGRLKAEARQKNLYSHAQFGDNNYPGHTDCEWLIVAESGYGIELTFTTFEVEEEADCGYDYIEL- 960

  Fly   976 EEGYSMNTIH--GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISF 1023
            .:||.... |  |||||......:.|..|.:|:.|.:|::.|.:||.|.:
Zfish   961 YDGYDTGA-HKIGRFCGSGPREELYSAGDAVLIHFHSDDTISKKGFHIRY 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	108/200 (54%)
		Astacin	144..339	CDD:279708	105/194 (54%)
		CUB	388..474	CDD:214483	36/85 (42%)
		CUB	478..586	CDD:278839	59/108 (55%)
		FXa_inhibition	595..630	CDD:291342	17/35 (49%)
		CUB	634..750	CDD:278839	49/116 (42%)
		FXa_inhibition	757..792	CDD:291342	23/34 (68%)
		CUB	797..906	CDD:278839	42/108 (39%)
		CUB	910..1023	CDD:278839	40/114 (35%)
tll1	NP_571085.1	ZnMc_BMP1_TLD	157..356	CDD:239808	108/200 (54%)
		Astacin	164..357	CDD:279708	105/194 (54%)
		CUB	358..467	CDD:278839	46/133 (35%)
		CUB	471..580	CDD:278839	60/110 (55%)
		FXa_inhibition	591..623	CDD:291342	16/31 (52%)
		CUB	627..736	CDD:278839	49/116 (42%)
		FXa_inhibition	743..778	CDD:291342	23/34 (68%)
		CUB	783..892	CDD:278839	42/108 (39%)
		CUB	896..1009	CDD:278839	40/114 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595338
Domainoid	1	1.000	288	1.000	Domainoid score	I1534
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	990	1.000	Inparanoid score	I294
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm6442
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810