DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and tok

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster

Alignment Length:	1007	Identity:	535/1007 - (53%)
Similarity:	711/1007 - (70%)	Gaps:	61/1007 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 RQH-------SGRRRKQSHKSQNKAALRL----PPPFLWTDDA-------VDVLQHSHSPTLNGQ 129
            |||       ..||::|.|:.:.::..:.    ||.|..:..|       :|:|:...|.  :.:
  Fly   449 RQHHQSHHRKKHRRQQQHHRRRGQSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSK--DEE 511

  Fly   130 PIQRR-RRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANY 193
            |::.| .||||.:|||.|||||||||||..|||.||||||.|||||||.||||||||||.:|.||
  Fly   512 PLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNY 576

  Fly   194 IYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGN 258
            |.|||::||||||:||.|||.|.|||||||:||||::|||||.:||.|||.|.||:||:||...|
  Fly   577 IVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNN 641

  Fly   259 IMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRL 323
            ||:||:|||::|||:|||...:.||.:||||||:|:|||..|||||.||.:......|:|||.||
  Fly   642 IMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRL 706

  Fly   324 SRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLT 388
            |:|||.||||||||..||||:|::||...||.. |:...:.:|.|
  Fly   707 SQGDIAQANLLYKCPKCGRTFQESSGIFASPSH-YTAGALSNETE-------------------- 750

  Fly   389 NCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSR 453
            :||||||||.||:|.|.|:.:::..|::|..|||||||||:.||||:.|.||.|..|||.|::||
  Fly   751 HCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSR 815

  Fly   454 MLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSI---DSPNYPMDYMPDKECVWRITAPDNH 515
            |||.|||.:..:|:|||||.|:|||||:|.:  |.::   :|||||:||:|:|||||:||.|:::
  Fly   816 MLLTYVNTHRIEGFRGFKAEFDVVCGGELSV--DDAVGRLESPNYPLDYLPNKECVWKITVPESY 878

  Fly   516 QVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQ 580
            ||||||||||:|.||.|.||:||:|||...|:.|||.|||.|.|||:|:..|.||::||||:|||
  Fly   879 QVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQ 943

  Fly   581 KLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNG 645
            |.||||..|.:||||:..:|||:|.||||||.|:|.||.|:||.::.|.||||||||::  ..||
  Fly   944 KAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIE--YPNG 1006

  Fly   646 SLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLK 710
            ::.|||:|::||..|:|:||:||||.|.:.|||:|||||||....:.|.||.:.:|||:.:||||
  Fly  1007 TITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLK 1071

  Fly   711 KIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSY 775
            :||.:||..:||...||.:.|||||:||:::|||||.|.|..|:|||::|||||||.||||.|||
  Fly  1072 RIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSY 1136

  Fly   776 QCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFH 840
            .|.|.|||::.||||:|.|..||:||:..:|.:.|||||:.||.|..|.|||.|..||||:|.|:
  Fly  1137 ICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFN 1201

  Fly   841 DFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKAT 905
            :|:|||||||.||.||:|||.||:||.||.:||.:.|:.:.:::|:|:|||.||...|:.||.|:
  Fly  1202 EFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTAS 1266

  Fly   906 FVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYD 970
            ..:.||||||||:..|.||||.|:|::.|...|.|:|.|.|...|.|::.||.|:||.||.|.:|
  Fly  1267 HSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFD 1331

  Fly   971 YLEI---TEEGYSM-NTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAV----- 1026
            |:::   .::.|.. ..::|::||...|..|.|.:.:||:||:||.|..::||:.|::||
  Fly  1332 YVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAVPNSGE 1396

  Fly  1027 -DPPEDSVGEDF--DAVTPFPGYLKSMYSSET 1055
             |..::.|...:  :.||||||.|||:|..:|
  Fly  1397 YDHSDEDVENSYSSEMVTPFPGSLKSIYIEDT 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	140/200 (70%)
		Astacin	144..339	CDD:279708	136/194 (70%)
		CUB	388..474	CDD:214483	50/85 (59%)
		CUB	478..586	CDD:278839	67/110 (61%)
		FXa_inhibition	595..630	CDD:291342	19/34 (56%)
		CUB	634..750	CDD:278839	62/115 (54%)
		FXa_inhibition	757..792	CDD:291342	24/34 (71%)
		CUB	797..906	CDD:278839	59/108 (55%)
		CUB	910..1023	CDD:278839	49/116 (42%)
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	140/200 (70%)
		Astacin	527..721	CDD:279708	135/193 (70%)
		CUB	723..836	CDD:294042	62/133 (47%)
		CUB	840..951	CDD:278839	69/112 (62%)
		FXa_inhibition	958..993	CDD:291342	19/34 (56%)
		CUB	997..1111	CDD:278839	62/115 (54%)
		FXa_inhibition	1118..1153	CDD:291342	24/34 (71%)
		CUB	1158..1267	CDD:278839	59/108 (55%)
		CUB	1271..1390	CDD:238001	50/118 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444859
Domainoid	1	1.000	288	1.000	Domainoid score	I1534
eggNOG	1	0.900	-	-		E1_KOG3714
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	990	1.000	Inparanoid score	I294
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm6442
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	P	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
	11	10.800