DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and MEP1A

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	730	Identity:	156/730 - (21%)
Similarity:	254/730 - (34%)	Gaps:	236/730 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 IQRRRRAVTVRKERTWDYGVIPYEI-DTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYI 194
            :|:.|..:.....| |.: .|||.: |.:...|..|:. .|...:...:|:.|...:.  .::||
Human    89 LQKSRNGLRDPNTR-WTF-PIPYILADNLGLNAKGAIL-YAFEMFRLKSCVDFKPYEG--ESSYI 148

  Fly   195 YFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNI 259
            .|...: ||.|.:|....| |.||||:.|....||.||:.|.:||:||.:|.|||.::.|....|
Human   149 IFQQFD-GCWSEVGDQHVG-QNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQI 211

  Fly   260 MRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLS 324
            :.|.::|||......:.....|||..|:|||...||:|:..:.||| ..||....: :|||...|
Human   212 LSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTIT-AKIPEFNSI-IGQRLDFS 274

  Fly   325 RGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGD----AGEDPSAESEFDA 385
            ..|:.:.|.:|.|.:.         |.:..|..:....:....:|:.|    |.:|.:...|.|.
Human   275 AIDLERLNRMYNCTTT---------HTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDH 330

  Fly   386 SLT-NCE-----WRITATNG---EKVILHLQQLHLMSSDDCTQDYLEI-------------RD-- 426
            :|. .|.     .:.:.::|   |..:|..:.|:......|.|.:.::             ||
Human   331 TLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDS 395

  Fly   427 -GYWHKSPLVRRICG-------------------------------NVSG-----EVITTQT--- 451
             |...|...|:...|                               |.:|     ::..|:|
Human   396 TGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCP 460

  Fly   452 ---------SRMLLN------------------------YVNRNAAKGYRGFKARFEVVCGG--- 480
                     |::|.|                        |.|...:.||  .:..|. ||.|
Human   461 TGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGY--LRLAFH-VCSGEND 522

  Fly   481 ---------------------DLKLTKDQSI-------------------DSPNYPMDYMPDKEC 505
                                 |::.....|:                   |.|:....|..|..|
Human   523 AILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNC 587

  Fly   506 VWRI----TAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNH-SDSRLIGRFCGDKLPPN---I 562
            ...|    :...:||: ||.:|| |:..|  ...||:..|..| |.:.:..:  |.:|.|.   :
Human   588 FRSIDLGWSGFISHQM-LKRRSF-LKNDD--LIIFVDFEDITHLSQTEVPTK--GKRLSPQGLIL 646

  Fly   563 KTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECK-------------FTDHG------------- 601
            :.:..|     ||:....|.....||.:.:.:.:             ..||.
Human   647 QGQEQQ-----VSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNP 706

  Fly   602 CQH--LCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVW 664
            ||:  :|:|..|...|.|.:|:.....|:.|:        |.:.:||:               :.
Human   707 CQNDGICVNVKGMASCRCISGHAFFYTGERCQ--------AVQVHGSV---------------LG 748

  Fly   665 EVVAPPNHAVFLNFS 679
            .|:......:||.||
Human   749 MVIGGTAGVIFLTFS 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	66/201 (33%)
		Astacin	144..339	CDD:279708	67/195 (34%)
		CUB	388..474	CDD:214483	24/182 (13%)
		CUB	478..586	CDD:278839	30/158 (19%)
		FXa_inhibition	595..630	CDD:291342	11/62 (18%)
		CUB	634..750	CDD:278839	8/46 (17%)
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	68/206 (33%)
		Astacin	101..289	CDD:279708	67/196 (34%)
		MAM	292..459	CDD:214533	25/166 (15%)
		MAM	297..459	CDD:99706	24/161 (15%)
		MATH_Meprin_Alpha	459..622	CDD:239752	29/169 (17%)
		EGF_CA	700..738	CDD:238011	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810