DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and CG6974

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster

Alignment Length:	215	Identity:	68/215 - (31%)
Similarity:	102/215 - (47%)	Gaps:	18/215 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKF--VERDPNLHANYIY 195
            :.|.|:|...:| |....|.|.|.|.:|....|..:.||..:...||::|  :|..|.....|:.
  Fly    45 KTRNALTSPLQR-WPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVS 108

  Fly   196 FTVKNCGCCSFLGKNGNGRQPISIG-------RNCEKF-GIIIHELGHTIGFHHEHARGDRDKHI 252
            |. |:...|.    ...|.||:|.|       ..|... .:|.||..|.:|..||.:|.|||:::
  Fly   109 FK-KSPNMCG----TRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYV 168

  Fly   253 VINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLEL 317
            .|:..||.|  :|....::.::.....:|||..|:|||:||:|:|.|...||..:........|:
  Fly   169 QIDYDNIPR--KYWSQFMAMDQTTTFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREM 231

  Fly   318 GQRKRLSRGDIVQANLLYKC 337
            ||.:..|.||..:..|:|||
  Fly   232 GQVRGPSEGDWTKIRLMYKC 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	67/211 (32%)
		Astacin	144..339	CDD:279708	65/204 (32%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	63/203 (31%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	60/196 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840