DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Tll2

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001178827.1	Gene:	Tll2 / 365460	RGDID:	1559756	Length:	1014	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	416/890 - (46%)
Similarity:	562/890 - (63%)	Gaps:	40/890 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFT 197
            |.|||.|.|.||.|..|||||.|...|:|..:|:|||||||||..||:.|:||..  ..::|.|:
  Rat   145 RVRRATTSRTERIWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEKHTCVTFIERTD--EESFIVFS 207

  Fly   198 VKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRG 262
            .:.|||||::|:.|.|.|.||||:||:||||:.|||||.:||.|||.|.|||:|:.|.:.||..|
  Rat   208 YRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPG 272

  Fly   263 QEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGD 327
            |||||..:...||......||.:||||||:|:||:..:||||.|.....|....:|||.|||:||
  Rat   273 QEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGD 337

  Fly   328 IVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEW 392
            |.||..||||.:||.|.|..||:..:|.|   .||.                     .|.::|.|
  Rat   338 IAQARKLYKCPACGETLQDTSGNFSAPGF---PNGY---------------------PSYSHCVW 378

  Fly   393 RITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLN 457
            ||:.|.|||:||:...:.|..|..|..||:|||||||.|:||:.|.||:...|.:.:..||:.:.
  Rat   379 RISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKVPEPLVSSDSRLWVE 443

  Fly   458 YVNRNAAKGYRGFKARFEVVCGGDLKLTKDQ-SIDSPNYPMDYMPDKECVWRITAPDNHQVALKF 521
            :.:.::..| :||.|.:|.:||||  :|||. .|.|||||.||.|.||||||||..|...|.|.|
  Rat   444 FRSSSSILG-KGFFAVYEAMCGGD--ITKDAGQIQSPNYPDDYRPSKECVWRITVADGFHVGLTF 505

  Fly   522 QSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSA 586
            ||||:|:||.||||::|||||...:|.|||.|||.:.|..:|:.:|:::::||||.|:.|.||:|
  Rat   506 QSFEIERHDSCAYDYLEIRDGPTEESALIGHFCGYEKPEAVKSSANRLWVKFVSDGSINKAGFAA 570

  Fly   587 ALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSP 650
            :...:||||.:.|| ||:..|:||||||.|.|..||||.||.||||.||||.:  ||.||::.||
  Rat   571 SFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAANKKTCEVACGGFI--TKLNGTITSP 633

  Fly   651 SYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIY 715
            .:|..||.:|.|||:||||..:.:.|.|..|:|||.    ..|.||::.:.|.:..: .|..|.:
  Rat   634 GWPKEYPTNKNCVWQVVAPMQYRISLQFEAFELEGN----DVCKYDFVEVRSGLSPD-AKLHGKF 693

  Fly   716 CGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCR 780
            ||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.|||:.:|||||..|.||||||.|.||
  Rat   694 CGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQQECVNTFGSYLCRCR 758

  Fly   781 NGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVE 845
            |||.|.||||:|.|..|.::|:::.|.|.|||:|:.||....|.|:..:..|||:::||.:||||
  Rat   759 NGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEVE 823

  Fly   846 SHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSEC 910
            .||||.||::.:|||...::..||.:||.::|..|:|:.:.:|:...:||.:|||||:|...:||
  Rat   824 QHQECAYDHLELYDGTDSSAPILGRFCGSKKPDPVVATGSSLFLRFYSDASVQRKGFQAVHSTEC 888

  Fly   911 GGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEIT 975
            ||.|:|...::..|||.::|...|....:|||.|.|:....|::.|..||:|....|.||||| .
  Rat   889 GGRLKAEVQTKELYSHAQFGDNNYPSQAHCDWVIVAEDGYGVELVFRTFEVEEEADCGYDYLE-A 952

  Fly   976 EEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGF 1019
            .:||..:... |||||......|.|..|:|::.|.||::.:.:||
  Rat   953 YDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIHFHTDDTINKKGF 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	107/200 (54%)
		Astacin	144..339	CDD:279708	104/194 (54%)
		CUB	388..474	CDD:214483	35/85 (41%)
		CUB	478..586	CDD:278839	62/108 (57%)
		FXa_inhibition	595..630	CDD:291342	21/35 (60%)
		CUB	634..750	CDD:278839	48/115 (42%)
		FXa_inhibition	757..792	CDD:291342	24/34 (71%)
		CUB	797..906	CDD:278839	46/108 (43%)
		CUB	910..1023	CDD:278839	42/111 (38%)
Tll2	NP_001178827.1	ZnMc_BMP1_TLD	149..348	CDD:239808	107/200 (54%)
		Astacin	156..349	CDD:279708	104/194 (54%)
		CUB	350..459	CDD:278839	46/133 (35%)
		CUB	463..572	CDD:278839	63/110 (57%)
		FXa_inhibition	583..615	CDD:291342	20/31 (65%)
		CUB	619..728	CDD:278839	48/115 (42%)
		FXa_inhibition	735..770	CDD:291342	24/34 (71%)
		CUB	775..884	CDD:278839	46/108 (43%)
		CUB	888..1001	CDD:278839	42/111 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1530
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1013	1.000	Inparanoid score	I270
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8929
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880