DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and nas-39

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001360030.1	Gene:	nas-39 / 3565986	WormBaseID:	WBGene00003555	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	929	Identity:	382/929 - (41%)
Similarity:	535/929 - (57%)	Gaps:	70/929 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 NGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHA 191
            ||    |..||.|.:|||.|..|:||:.|.:.|||.|:.||.:||||||||||:.||.|.|: |.
Worm    42 NG----RVSRAATAKKERIWPEGIIPFVIASNFSGEHQHLFLRAMRHWENFTCVSFVPRQPH-HK 101

  Fly   192 NYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINK 256
            :||.|||..|||||::|:.|.|.|.||||:||:||||::|||||.:||.|||.|.|||.::.|..
Worm   102 HYITFTVDKCGCCSYVGRRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDMYVDIFY 166

  Fly   257 GNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPP--GTHLELGQ 319
            .:|..||:|||:...|||||....|||.:||||||:::||:..:.|||.|   .|  |..||:||
Worm   167 KSIQTGQDYNFEKSKPEEVDSLGEPYDFSSIMHYARDTFSRGAFYDTILP---KPNSGFRLEIGQ 228

  Fly   320 RKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFD 384
            |.:||.|||.|...|||||.||.|..|.||::...|                 ||.
Worm   229 RVQLSEGDIRQTKKLYKCAECGGTLMQESGNLAIQH-----------------AGV--------- 267

  Fly   385 ASLTNCEWRITATNGEKVILHLQQLHLM-SSDDCTQD---YLEIRDGYWHKSPLVRRICGNVS-G 444
                 |.|.|.:..|..:.|::....|. .|..|.::   .:.:|||....||::.||||..| .
Worm   268 -----CTWHIISPQGHTIFLNITGSTLSPPSSLCGKEEDNVITVRDGVSISSPVLDRICGGDSLF 327

  Fly   445 EVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRI 509
            ..|.:..:|||:. |..:.......| |.:..:|||.: ...:..|.||.||..|.|:.:|.|.|
Worm   328 RTIASSGNRMLIQ-VRSSTPAASLPF-ATYYAICGGPI-YANEGVIHSPKYPESYPPNSDCQWTI 389

  Fly   510 TAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGR-----FCGDKLPPNIKTRSNQM 569
            ...:|.|||::|..|.||:|..|.||.:.:.:|...:|:..|:     |||......|.:::||:
Worm   390 HVDENSQVAIEFVYFHLEQHKECIYDRLILTEGISKNSKKDGKEMSETFCGLIEKKTIVSKTNQI 454

  Fly   570 YIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDAC 634
            .:||.||:||||.||......:::||....:.|.|.|:||:|.::|.||.||.|.:||.:|:..|
Worm   455 SLRFFSDNSVQKTGFELRFTKELNECATDKNICHHYCVNTVGGFKCACRVGYSLSSNGFSCDSTC 519

  Fly   635 GGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLI 699
            ||.:.|  ||||:.||::|::|||||.|:||:.||..:.:||||:.|::||.:   |:|.|||:
Worm   520 GGYLKA--SNGSISSPNFPEMYPNSKTCIWEIEAPDGYHIFLNFTKFNVEGMK---TECAYDYV- 578

  Fly   700 IYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGC 764
               |:.|:. |..|.|  || ..:..:.::.:|:||.||.:|:|.||.|.|:.|.|||..:|.||
Worm   579 ---KIGDSE-KLCGEY--HE-ALLFTTPRNRVRIEFSSDSSVERDGFFANFIADFDECQNDNAGC 636

  Fly   765 QHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQT 829
            :|.|:|..|||.|:|..||.|||:.|||.|..|.||:....|.:.|||||.|||:...|.|||.|
Worm   637 EHTCQNRLGSYVCTCNPGYILAEDKHNCKEGSCFFEVNAPAGDINSPNYPNDYPKGQNCSWHFVT 701

  Fly   830 VLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATD 894
            ..|||:.|||..|:||.|.:|.||.|::|||...::...|::||...|..:::|:||:::..::|
Worm   702 TPGHRLMLTFSSFQVEEHAQCKYDAVSVYDGGDGSAQLAGVFCGLAPPPLLLSSSNELYLTFSSD 766

  Fly   895 AGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQA-DPESSVKIRFLH 958
            |.:.|:||:|.:.|.|||.|.|.:.....|||..:....|.:|..|.|.::| .|...|:|:|..
Worm   767 ASVSRRGFQAHYTSLCGGRLTAESTPGHIYSHATFSDSKYGKNQDCSWIVRAKSPGRGVRIQFST 831

  Fly   959 FEIEYSERCDYDYLEITE-EGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAIS 1022
            |.||..|.|.|||:||.: ...::..:.|||||...|.:|.|....|||...||.:...:||...
Worm   832 FNIESEEGCQYDYIEIYDGPEATLERLVGRFCGDTSPEVITSTGPELLLIMHTDNAEEEKGFVAE 896

  Fly  1023 FMAVDPPEDSVGEDFDAVT 1041
            :... |...|....|.:.|
Worm   897 YREA-PRSSSTKRTFVSKT 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	112/202 (55%)
		Astacin	144..339	CDD:279708	109/196 (56%)
		CUB	388..474	CDD:214483	25/90 (28%)
		CUB	478..586	CDD:278839	44/112 (39%)
		FXa_inhibition	595..630	CDD:291342	15/34 (44%)
		CUB	634..750	CDD:278839	50/115 (43%)
		FXa_inhibition	757..792	CDD:291342	18/34 (53%)
		CUB	797..906	CDD:278839	47/108 (44%)
		CUB	910..1023	CDD:278839	42/114 (37%)
nas-39	NP_001360030.1	ZnMc_BMP1_TLD	48..247	CDD:239808	112/202 (55%)
		CUB	268..343	CDD:214483	23/75 (31%)
		CUB	359..474	CDD:238001	44/115 (38%)
		FXa_inhibition	480..515	CDD:373209	15/34 (44%)
		CUB	519..622	CDD:366096	50/115 (43%)
		FXa_inhibition	629..664	CDD:373209	18/34 (53%)
		CUB	669..780	CDD:238001	47/110 (43%)
		CUB	782..898	CDD:238001	42/115 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I982
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	761	1.000	Inparanoid score	I278
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		otm14446
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840