DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and Semp1

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster

Alignment Length:	238	Identity:	68/238 - (28%)
Similarity:	110/238 - (46%)	Gaps:	31/238 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 DVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEI-DTIFSGAHKALFKQAMRHWENFTC 179
            ::|...:...:...||  |.|...|.:...|....:||.| |..|:.:|.....:|:...|..:|
  Fly    25 ELLAGFYQGDIKAHPI--RTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSC 87

  Fly   180 IKFVERDPNLHANY---IYFTVKNCGCCS-FLGKNGNGRQPIS-----IGRNCEKFGIIIHELGH 235
            :.|   .|....::   :..|.|..||.: .||.. |..|.::     :|..|.:.|.|||||.|
  Fly    88 VIF---KPATEMDFPMALVITSKGLGCNTVHLGYR-NKTQVVNLEIYPLGEGCFRIGSIIHELLH 148

  Fly   236 TIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPE------EVDLPLLPYDLNSIMHYAKNS 294
            .:||.|:|...:||:::.|...||  ..:||.:.::.:      :.|   ..||..|:|||...:
  Fly   149 VLGFEHQHVSQNRDQYVSIQWKNI--NPQYNINFVNNDNSTAWHDFD---EGYDYESVMHYVPRA 208

  Fly   295 FSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKC 337
            ||::.. .||.|  :..|.. .:|||..:|..||.:.|.:|:|
  Fly   209 FSRNGQ-PTIVP--LREGAE-NMGQRFYMSEKDIRKLNKMYRC 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	63/217 (29%)
		Astacin	144..339	CDD:279708	62/210 (30%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	62/208 (30%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	59/202 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840