DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and mep1bb

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_009294699.1	Gene:	mep1bb / 327586	ZFINID:	ZDB-GENE-030131-5797	Length:	774	Species:	Danio rerio

Alignment Length:	433	Identity:	117/433 - (27%)
Similarity:	167/433 - (38%)	Gaps:	71/433 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DDAVDVLQHSHSPTLNGQPI--QRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHW 174
            :|..||.:.:......|..:  :...|...:.:|..|. ..|||..:.......|.:..:|...:
Zfish    47 EDLFDVNEDAGLDLFEGDILYDETLGRNSIIGEEYRWP-KTIPYYFEDDLEINAKGVILKAFEQY 110

  Fly   175 ENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGF 239
            ...|||.:  :......||| ...|..||.|.:|....|||.:|||..|::...|.||..|.:||
Zfish   111 RLKTCIDY--KPWTGEENYI-SVFKGNGCFSSVGNRRVGRQTLSIGSGCDRIATIEHEFLHALGF 172

  Fly   240 HHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTI 304
            .||.:|.|||.::.|....|..|:|:||:..:........:|||.:|:|||::.:|........|
Zfish   173 WHEQSRSDRDDYVSIMWDRITEGKEHNFNKYNDSSSSALNVPYDYSSMMHYSQKAFQSGSEPTII 237

  Fly   305 TPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEG 369
            |.|   |.....:|||...|..|:::.|.||.|.|             |..|:.|.:..|....|
Zfish   238 TRI---PAFSSVIGQRMEFSDSDLLKLNRLYNCTS-------------SSTFLDSCDFELENICG 286

  Fly   370 SGDAGED---------PSAESEFDASLTN---CEWR------ITA--TNGEKVILHLQQLHLMSS 414
            ....||.         |.|....|...||   ||.:      .||  ..|.|.:|..:.|:....
Zfish   287 MIQKGEADSTAEWRRVPEAAGGPDTDYTNMGRCEGKGYFMHFSTAGGPEGAKALLESRVLYPKRG 351

  Fly   415 DDCTQDYLEIRDGYWHKSPLVR-----RICGNVSGEVITTQT------SRMLLNYVNRNAAKGYR 468
            ..|.| :.....|  |.|..:|     ....|.:|.:...|.      .|..|.:::.|.:   |
Zfish   352 FQCLQ-FFVFNSG--HTSDRLRIWTREFDTENPNGTLRLVQQIHAPPGERWQLQHISLNVS---R 410

  Fly   469 GFKARFEVVCG----GDLKLTKDQSIDSPNYPMDYMPDKECVW 507
            .|:..||...|    |.|      |||..|......||.  ||
Zfish   411 KFRVVFEGTKGTGSSGGL------SIDDINLSETRCPDH--VW 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	63/200 (32%)
		Astacin	144..339	CDD:279708	63/194 (32%)
		CUB	388..474	CDD:214483	24/107 (22%)
		CUB	478..586	CDD:278839	11/34 (32%)
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
mep1bb	XP_009294699.1	ZnMc	39..267	CDD:294052	68/226 (30%)
		Astacin	81..269	CDD:279708	63/194 (32%)
		MAM	277..441	CDD:279023	40/175 (23%)
		MAM	277..440	CDD:99706	40/174 (23%)
		MATH	440..608	CDD:295307	4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810