DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Cubn

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	236/958 - (24%)
Similarity:	376/958 - (39%)	Gaps:	218/958 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DTIFSGAHKALFKQAMR---------HWENFTCIKFVERDPNLHANYIY--FTVKNCGCCSF--L 207
            :|.||..:..|..|:.|         :..|..|...:..:.:|..|..:  |.|::...|.|  |
  Fly   503 ETRFSSCNGMLSAQSGRLRYPPEGTGYEHNAQCAWVIRTNESLVVNVTFNSFDVEDSTECRFDWL 567

  Fly   208 GKNGNGRQPIS--IGRNC-----------------------------EKFGIIIHELGHTIGFHH 241
            ..| :||...:  |||.|                             |.|.:..:.:....|
  Fly   568 QIN-DGRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEPQCG--- 628

  Fly   242 EHARGDRDKHIVI----NKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMH--------YAKNS 294
              .|.:.:.|..:    :.||..:.::..:.:::|....:.|..:.|....|        ..|:|
  Fly   629 --GRLNFETHGTLASPGSPGNYPKNRDCRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDS 691

  Fly   295 FS---KSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLY----KCASCGRTYQQNSGHIV 352
            .|   .:.|..|..|..:...|||........:.|......|.|    :...||..|.
  Fly   692 ISGRELAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSVEERVPGCGGVYT------- 749

  Fly   353 SPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDC 417
                  :..|.:||   |..|..:|...|        ||:.|....||:|::...:|.| ...||
  Fly   750 ------AKEGTISE---SSTANTEPGGVS--------CEYEIHLAVGEQVVIQFARLEL-DPLDC 796

  Fly   418 TQDYLEIRD--GYWHKSPLVRRICGN----VSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEV 476
            . :.|:|.|  |    |.|..:|||:    ::....|::.:|:.:.:..|..:     |:..:.:
  Fly   797 L-EVLDITDEGG----SILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGS-----FQLNYRM 851

  Fly   477 VCGGDLKLTKDQ-SIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFEL-------EKHDGCA 533
            .|  |.||..:| :|.||.||.....|:.|.:.|:...|..::||...|:|       :.:|.|.
  Fly   852 AC--DYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDECL 914

  Fly   534 YDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFT 598
            ...:.|.||  .:.:::|.:||          .||....|||:::..:|..|.    |||
  Fly   915 TTNLRINDG--LNRKILGPYCG----------KNQPEENFVSETNYLQLHLST----DVD----- 958

  Fly   599 DHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCV 663
                      ::|.   |.:..|...|.|   .|.||||  .|:|...:..|.:.|.|.....|.
  Fly   959 ----------SMGR---GFKFEYRALATG---NDKCGGV--HTRSGDHIRLPVHDDSYAGEATCY 1005

  Fly   664 WEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIY----SKMRDNRLKKIGIYCGHELPPVV 724
            |.::||.|.|:.|:::.|.||..    ..|.||||.||    :::.|.|.|.:..|||:.:|..:
  Fly  1006 WVIMAPANKAIRLHWNSFSLENA----VDCIYDYLEIYDSLGAQVNDERSKPLAKYCGNSVPEDL 1066

  Fly   725 NSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENG 789
            .|....|.|:|.||.:....||      |:.                           ||..:
  Fly  1067 LSHSRQLVLKFVSDYSESDGGF------DLT---------------------------YTFED-- 1096

  Fly   790 HNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDY 854
                ..:|...|..|.|.|.||.||.:|...:.|.||....:.|.:::...:||:|....|..||
  Fly  1097 ----RAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFELEQSPNCSADY 1157

  Fly   855 VAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFK---ATFVSECGGYLRA 916
            :.:.:|...:|..:|.:||...|..:...::||.::|.||:.:..:||:   ..|...|||.||:
  Fly  1158 LEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGFRLRWRIFAFGCGGSLRS 1222

  Fly   917 TNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYD----YLEITEE 977
               :....|.||| ...|....:|:|||...|.|.:.:.....|:|....|.||    |..|...
  Fly  1223 ---NMGAISSPRY-PNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIKLP 1283

  Fly   978 GYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMA 1025
            ..|...:..:....|.|.|.:.|:...:: |.:|.||:.|||.||:.|
  Fly  1284 NQSPCKVLCKDDDLHNPLIQLENNKGTIV-FDSDASNTFRGFRISYKA 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	45/244 (18%)
		Astacin	144..339	CDD:279708	45/245 (18%)
		CUB	388..474	CDD:214483	23/91 (25%)
		CUB	478..586	CDD:278839	32/115 (28%)
		FXa_inhibition	595..630	CDD:291342	5/34 (15%)
		CUB	634..750	CDD:278839	41/119 (34%)
		FXa_inhibition	757..792	CDD:291342	2/34 (6%)
		CUB	797..906	CDD:278839	33/111 (30%)
		CUB	910..1023	CDD:278839	36/116 (31%)
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011	236/958 (25%)
		CUB	509..622	CDD:238001	21/113 (19%)
		CUB	627..737	CDD:238001	21/114 (18%)
		CUB	744..849	CDD:294042	33/139 (24%)
		CUB	853..970	CDD:238001	39/152 (26%)
		CUB	978..1094	CDD:238001	43/154 (28%)
		CUB	1100..1211	CDD:238001	33/110 (30%)
		CUB	1216..1330	CDD:238001	37/118 (31%)
		CUB	1446..1549	CDD:238001
		CUB	1554..1667	CDD:238001
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840