DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Adgrg6

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	73/299 - (24%)
Similarity:	117/299 - (39%)	Gaps:	73/299 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   797 CKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGR 861
            |:..::...|...||.||.|||....|.|..:...|:.||:||:||::|....||||.:::.:|.
  Rat    41 CRLVLSNPSGTFTSPCYPNDYPNTQSCSWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNGE 105

  Fly   862 SENSSTLGIYCGG-REPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYS 925
            |:..     :||. .:..:..:|.|||.:..::|..:|:|||.|:::.     :..:..:|...
  Rat   106 SQTK-----FCGATAKGLSFNSSVNEMHVSFSSDFSIQKKGFNASYIR-----VAVSLRNQKVI- 159

  Fly   926 HPRYGSRPYKRNMYCDWRIQADPESSVKIRFLH-----FEIEYSERCDYDY-------------- 971
                  .|...:.|     |.....|:.|..|.     ||.......|.|:
  Rat   160 ------LPQTLDAY-----QVSVAKSISIPELKAFTLCFEASKVGNEDDDWTAFSYSDKSLTQLL 213

  Fly   972 -LEITEEGYSMNTIHGRFC-------GKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFM---- 1024
             ||....||.: :|.|..|       .|.|..|...|.:.|.|.:    :||.....|:|.
  Rat   214 SLEKANNGYFL-SISGARCLLNNALPVKEKEDIFTGNFEQLCLVW----NNSWGSVGINFKKNYE 273

  Fly  1025 ---------AVDPPEDS--VGEDFDAVTPFPGYLKSMYS 1052
                     .|.|.:.:  :|.|.|.:....|   |:|:
  Rat   274 TIPCDLTIGTVVPGDGTLLLGSDRDEIASLKG---SVYN 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839	37/109 (34%)
		CUB	910..1023	CDD:278839	27/139 (19%)
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001	37/109 (34%)
		LamG	178..337	CDD:304605	30/140 (21%)
		GPS	799..844	CDD:280071
		7tm_4	861..1108	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900