DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and Cdcp2

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_038967409.1	Gene:	Cdcp2 / 298306	RGDID:	1563467	Length:	566	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	135/478 - (28%)
Similarity:	212/478 - (44%)	Gaps:	92/478 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 CINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPP 670
            |:..:.:.....:..:.|.:..|     ||||:.|...|.|  ||::|.:||.:.:|.|.:|...
  Rat    33 CLTRIQNPGADSQPSFSLASGVK-----CGGVLSAPSGNFS--SPNFPSLYPYNTECSWLIVVAE 90

  Fly   671 NHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEF 735
            ..:|.|.|..||||   :|.| |.:|:|.||:....::...:|.:||...||...|...::.:.|
  Rat    91 GSSVLLTFHTFDLE---YHDT-CGFDFLEIYNGASRDKGNLLGRFCGQAPPPPFTSSWHVMSVVF 151

  Fly   736 YSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFE 800
            :||:.|...||.|.:..||                                          |...
  Rat   152 HSDKHVASRGFSAGYQKDV------------------------------------------CGGV 174

  Fly   801 ITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENS 865
            :|...|:|.||.||.:||.|:.|:|..:......::|.|.||:||..:||:||:|.:
  Rat   175 LTGLSGILSSPEYPNNYPNNVECHWLIRASGPATVKLVFVDFQVEGSEECMYDHVTV-------- 231

  Fly   866 STLGI--------YCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVS-ECGGYLRATNHSQ 921
              ||.        |||...|..:::..:|:.:|..:|..:..:||||.:.| ||.....|...:
  Rat   232 --LGAPGPAHGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAHYFSGECQEVFTAVRGN- 293

  Fly   922 TFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIE----YSERCDYDYLEITEEGYSMN 982
              :|.|:|.. .|..|:.|.|.|:..|...||:..|...:|    .:..||:|:|...:......
  Rat   294 --FSSPQYPG-AYPNNIRCHWTIRLPPGYRVKVFVLDLGLEEPNSLTRTCDFDHLAAFDGASEEA 355

  Fly   983 TIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGE-DF------DAV 1040
            .:.|::||.|.||.:.|:.:.|||...||.|.|.|||:::::.|.|...|... ||      .|:
  Rat   356 KLLGKWCGHHLPPPVTSSHNQLLLLLHTDRSTSGRGFSVAYIGVVPMNVSCSRTDFQILISAQAL 420

  Fly  1041 TPFPG---YL--KSMYSSETGSD 1058
            .|...   ||  :|..:.|.||:
  Rat   421 APLERTKVYLGSRSCAAQEVGSN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342	3/23 (13%)
		CUB	634..750	CDD:278839	42/115 (37%)
		FXa_inhibition	757..792	CDD:291342	0/34 (0%)
		CUB	797..906	CDD:278839	37/116 (32%)
		CUB	910..1023	CDD:278839	36/116 (31%)
Cdcp2	XP_038967409.1	CUB	56..167	CDD:238001	42/116 (36%)
		CUB	171..280	CDD:238001	37/118 (31%)
		CUB	283..396	CDD:238001	36/116 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000