DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and Astl

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001099974.1	Gene:	Astl / 296129	RGDID:	1562279	Length:	436	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	112/411 - (27%)
Similarity:	169/411 - (41%)	Gaps:	106/411 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQ 84
            ||:||..|..|:... |..|.....|.|.           |:..:|:.....|:
  Rat     4 VGSLWPWMLTLLSLT-GLILGAPSASRCS-----------GVCSTSVPEGFTPE----------- 45

  Fly    85 HSGRRRKQSH--KSQNKAALRLPPP---FLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKER 144
              |.|..|..  .:.|:..:....|   ||...|.:             :|...|..:||..|
  Rat    46 --GSRVSQDKDIPAINQGLISEETPESSFLVEGDII-------------RPSPFRLLSVTNNK-- 93

  Fly   145 TWDYGV-----IPYEIDTIFSGAHKALFKQAMRHWENFTCIKFV----ERDPNLHANYIYFTVKN 200
             |..||     ||:.:.:.:....:.:..:|...:|.||||:||    :||       ....:..
  Rat    94 -WPKGVDGIVEIPFLLSSKYDEPSRQVIMEAFAEFERFTCIRFVAYRGQRD-------FVSILPM 150

  Fly   201 CGCCSFLGKNGNGRQPISIGRNC--EKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQ 263
            .||.|.:|::| |.|.:|:...|  :..||::|||.|.:||.|||:|.|||::|.:|...|:.|.
  Rat   151 AGCFSGVGRSG-GMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHSRADRDRYIRVNWNEILPGF 214

  Fly   264 EYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFS--KSPYLDTITPIGIPPGTHLELGQRKRLSRG 326
            |.||  :.....:: |.|||.:|:|||.:.:||  ..|   ||.|:..   :.:.:|||..||..
  Rat   215 EINF--IKSRNSNM-LAPYDYSSVMHYGRFAFSWRGQP---TIIPLWT---SSVHIGQRWNLSTS 270

  Fly   327 DIVQANLLYKCA-----SCGRTYQQNS-GHIVSPHFI-----------------------YSGNG 362
            ||.:...||.|:     |.||.::..| |...:|..|                       ..|.|
  Rat   271 DITRVCRLYSCSPSVPDSHGRGFEAPSDGRSPTPASISHLQRLLEALSEESRSSAPSGSGTGGQG 335

  Fly   363 VLSEFEGSGDAGEDPSAESEF 383
            :::.|..|....|.| |:|.|
  Rat   336 IIAGFVDSQQGWEHP-AQSTF 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	72/213 (34%)
		Astacin	144..339	CDD:279708	70/212 (33%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Astl	NP_001099974.1	Astacin	92..283	CDD:279708	71/210 (34%)
		ZnMc	99..281	CDD:294052	66/198 (33%)
		ImpA_N	<305..420	CDD:303075	10/52 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810