Protein Alignment tld and Fbln2

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_001093960.1
• Gene: Fbln2 / 282583
• RGDID: 628685
• Length: 1221
• Species: Rattus norvegicus
• Alignment Length: 995
• Identity: 204/995 - (20%)
• Similarity: 315/995 - (31%)
• Gaps: 364/995 - (36%)

  Fly    42 LPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPP 106
            ||..|.:.:.|..||:       :|:|..:        .|:|..:    ::......|:.|....
  Rat   309 LPVQEKEAEAKAGPEE-------NLIPEAQ--------ATSRSVT----QEGAAPLPKSGLAGLS 354

  Fly   107 PFLWTD-DAVDVLQHSHSPTLNGQP----------------IQRRRRAVTVRKERTWDYGVIPYE 154
            |.|.|| .:.|.|:.|..|||:..|                .||.:.....|.|...|    |..
  Rat   355 PSLATDSSSEDALKSSSQPTLSTLPPDRAQVSPSPETPEEIPQRPQLLPRSRAEEDTD----PNS 415

  Fly   155 IDTI----FSGAHKALFK---QAMRHW--ENFTCIKFVE--------RDPNLHANYIYFTVKN-- 200
            :.::    ..|:.|.|.:   .|.:.|  :|..|.:..|        |....|....|...|:
  Rat   416 VHSVPRGDPDGSTKDLVETCCAAGQQWAIDNDECQEIPENGAQSDVCRIAQRHCCISYLKEKSCV 480

  Fly   201 ----------------------------CGCCSFLGKNGNGRQPISIGRNCE---KFG------- 227
                                        |.||      |.|.:..:.|::||   ..|
  Rat   481 AGVMGAKEGETCGAEDNDTCGVSLYKQCCDCC------GLGLRVRAEGQSCESNPNLGYPCSHVM 539

  Fly   228 ---------IIIHEL------GHTIGFHHEHARGDRDKHIVINKG------NIMRGQEYNFDVLS 271
                     :|:.|:      |.|.....|...|.|:   .::.|      |.:.|.:.:..::.
  Rat   540 LSCCEGEEPLIVPEVRRPPEPGATPRRVSETEMGSRE---ALSLGTEAELPNSLPGDDQDECLML 601

  Fly   272 PEEVDLPLLPYDLNSIMHYAKNSF---------------SKSPYLDT------------ITPIGI 309
            |.|:...|.   :|::..|....|               ..:|.|||            ::|..|
  Rat   602 PGELCQHLC---INTVGSYRCACFPGFELQGDGRTCRPDGGAPQLDTARESAPRSESAQVSPNTI 663

  Fly   310 P-----PGTHLELGQRKRLSR--GDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEF 367
            |     |.|..:.|..:::.|  ||...       .||                 :.|..::::
  Rat   664 PLPVPQPNTCKDNGPCRQVCRVIGDTAM-------CSC-----------------FPGYAIMAD- 703

  Fly   368 EGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKS 432
               |.:.||   :.|......:|.|:....|            .:.|..|....:...:||...:
  Rat   704 ---GVSCED---QDECLMGTHDCSWKQFCVN------------TLGSFYCVNHTVLCAEGYILNA 750

  Fly   433 PLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPM 497
               .|.|.:::..|....|.....:.||...:  ::.:||   :.|.....||..:..|     :
  Rat   751 ---HRKCVDINECVTDLHTCTRAEHCVNTPGS--FQCYKA---LTCEPGYVLTDGECTD-----V 802

  Fly   498 DYMPDKECVWRITAPDNHQVALKFQ----SFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKL 558
            |     |||   |...|.|.....|    ||..:....|...|::..:||..|.    ..|...|
  Rat   803 D-----ECV---TGTHNCQAGFSCQNTKGSFYCQARQRCMDGFLQDPEGNCVDI----NECTSLL 855

  Fly   559 PPNIKTRSNQMYIRFVSDSSVQ------KLGFSA----ALMLDVDECKFTDHGC--QHLCINTLG 611
            .|   .||....|..|...:.|      :.|:.|    :..:||:||:...|.|  ..||.|..|
  Rat   856 EP---CRSGFSCINTVGSYTCQRNPLVCRRGYHANEEGSECVDVNECETGVHRCGEGQLCYNLPG 917

  Fly   612 SYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFL 676
            ||:|.|:.|::..|.|:||.|    |.:...|.|.|...:..:. |.|.:|
  Rat   918 SYRCDCKPGFQRDAFGRTCID----VNECWISPGRLCQHTCENT-PGSYRC-------------- 963

  Fly   677 NFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTV 741
                           .|...:|          |...|.:|.
  Rat   964 ---------------SCAAGFL----------LAADGKHCE------------------------ 979

  Fly   742 QRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYG 806
                       ||:||....  |...|.|.:|||||.||.||.|||:||.||:..   |.....|
  Rat   980 -----------DVNECETRR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDID---ECAQGAG 1028

  Fly   807 VL---QSPNYPEDY----PRNIY--------CYWHFQTVLG----------HRIQLTFHDFEVES 846
            :|   :..|.|..|    |...|        |....:..||          |.||.:|.....
  Rat  1029 ILCTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHNCSEAETCHNIQGSFRCLRF-- 1091

  Fly   847 HQECIYDYVAIYDGRSENSS 866
              :|..:||.:.:.:.|.::
  Rat  1092 --DCPPNYVRVSETKCERTT 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	54/312 (17%)
		CUB	388..474	CDD:214483	15/85 (18%)
		CUB	478..586	CDD:395345	28/117 (24%)
		FXa_inhibition	595..630	CDD:464251	14/36 (39%)
		CUB	634..750	CDD:395345	12/115 (10%)
		FXa_inhibition	757..792	CDD:464251	18/34 (53%)
		CUB	797..906	CDD:395345	19/95 (20%)
		CUB	910..1023	CDD:395345
Fbln2	NP_001093960.1	None