DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and PCOLCE2

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_037495.1	Gene:	PCOLCE2 / 26577	HGNCID:	8739	Length:	415	Species:	Homo sapiens

Alignment Length:	332	Identity:	99/332 - (29%)
Similarity:	156/332 - (46%)	Gaps:	68/332 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 CGGDLKLTKDQS-IDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRD 541
            |||  .||.:.. |.|..:|..|.|:.:|.|:||.|:...|.|.|:..:||..:.|.||||::.:
Human    33 CGG--ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYN 95

  Fly   542 GNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLC 606
            | |::.:.||||||...|..:.:..|:|.::.:||::....||.|  |....|.  .:.|.|:
Human    96 G-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMA--MFSAAEP--NERGDQY-- 153

  Fly   607 INTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPD-VYPNSKQCVWEVVAPP 670
                                       |||::|  :.:||..:|::|| .||....|||.:|||.
Human   154 ---------------------------CGGLLD--RPSGSFKTPNWPDRDYPAGVTCVWHIVAPK 189

  Fly   671 NHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEF 735
            |..:.|.|..||:|  |.:|  |.|||:.:::....|..::||.|||...|..:.||::.|.::|
Human   190 NQLIELKFEKFDVE--RDNY--CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQF 250

  Fly   736 YSDRTVQRSGFVAKFVIDVDECSMNN------------------GGCQHRCRNT---FGSYQCSC 779
            .||.::...||:..::....:.....                  ..||.:||.|   .|:|   |
Human   251 LSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNY---C 312

  Fly   780 RNGYTLA 786
            .:.:.||
Human   313 SSDFVLA 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839	40/108 (37%)
		FXa_inhibition	595..630	CDD:291342	2/34 (6%)
		CUB	634..750	CDD:278839	44/116 (38%)
		FXa_inhibition	757..792	CDD:291342	10/51 (20%)
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
PCOLCE2	NP_037495.1	CUB	33..143	CDD:238001	42/114 (37%)
		CUB	154..267	CDD:238001	44/118 (37%)
		NTR_PCOLCE	292..415	CDD:239631	10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S7146
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860