DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Mep1b

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_037315.1	Gene:	Mep1b / 25727	RGDID:	3081	Length:	704	Species:	Rattus norvegicus

Alignment Length:	616	Identity:	143/616 - (23%)
Similarity:	212/616 - (34%)	Gaps:	170/616 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 WDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKN 210
            |.: .|||.::.......|.:...|...:...|||.|  :..:...||| ...|..||.|.:|..
  Rat    72 WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDF--KPWSGEENYI-SVFKGSGCWSSVGNI 132

  Fly   211 GNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEV 275
            ..|:|.:|||.||::...:.||..|.:||.||.:|.|||.:|.|....|:.|:|:||::.:....
  Rat   133 HAGKQELSIGTNCDRIATVQHEFLHALGFWHEQSRADRDDYITIVWDRILSGKEHNFNIYNDSVS 197

  Fly   276 DLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLE--LGQRKRLSRGDIVQANLLYKCA 338
            |...:|||..|:|||:|.:|........||.|     :..|  :|||...|..|:::.|.||.|.
  Rat   198 DSLNVPYDYTSVMHYSKTAFQNGTESTIITKI-----SDFEDVIGQRMDFSDYDLLKLNQLYSCT 257

  Fly   339 S---------------CG--------RTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAE 380
            |               ||        ..:|:.|..:..|...:|..|..          :|....
  Rat   258 SSLSFMDSCDFELENICGMIQSSQDSADWQRLSQVLSGPENDHSNMGQC----------KDSGFF 312

  Fly   381 SEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYL-EIRDGYWHKSPLVRRICGNVSG 444
            ..|:.|        |...|...:|..:.|:......|.:.|| ....|....:...|........
  Rat   313 MHFNTS--------TGNGGITAMLESRVLYPKRGFQCVEFYLYNSGSGNGQLNVYTREYTAGHQD 369

  Fly   445 EVITTQ-------TSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPD 502
            .|:|.|       |....|.||.....:   .|:..||.| ||....:...|||..|     :.:
  Rat   370 GVLTLQREIRDIPTGSWQLYYVTLQVTE---KFRVVFEGV-GGPGASSGGLSIDDIN-----LSE 425

  Fly   503 KEC---VWRI--------------------------------TAPDNHQVALKFQSFELEKHD-- 530
            ..|   :|.|                                |:|.|  |.|.|........|
  Rat   426 TRCPHHIWHIQNFTQLLGGQTTVYSPPFYSSKGYAFQINLDLTSPTN--VGLYFHLISGANDDQL 488

  Fly   531 --GCAYD--FVEIRDGN------HSDSRLI----------GRFCGDKLP---------PN----- 561
              .|.:.  .:.:.|.|      .|:.|.|          |.:..|: |         ||
  Rat   489 QWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPKMTDDNGSYLWDR-PSKVGVEAFFPNGTQFS 552

  Fly   562 ---------------IKTR----SNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQH--- 604
                           :|:|    .:.:|| .::...:..|..:||:...|.......:.|..
  Rat   553 RGRGYGTSVFITQERLKSREFLKGDDVYI-LLTVEDISHLNSTAAVPGPVPTTSTVHNACSEVEC 616

  Fly   605 ----LCINTLGSYQCGCRAGYELQANGKTCE 631
                :|....|..:|.|.||.:....||.||
  Rat   617 QNGGICTLQEGRAECKCPAGEDWWYMGKRCE 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	65/193 (34%)
		Astacin	144..339	CDD:279708	66/194 (34%)
		CUB	388..474	CDD:214483	17/93 (18%)
		CUB	478..586	CDD:278839	32/197 (16%)
		FXa_inhibition	595..630	CDD:291342	9/41 (22%)
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Mep1b	NP_037315.1	ZnMc	30..256	CDD:294052	65/192 (34%)
		Astacin	70..258	CDD:279708	66/194 (34%)
		MAM	266..430	CDD:279023	37/190 (19%)
		MAM	266..428	CDD:99706	36/188 (19%)
		MATH	428..586	CDD:295307	25/161 (16%)
		EGF_CA	609..647	CDD:238011	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810