DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and Mep1a

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_037275.1	Gene:	Mep1a / 25684	RGDID:	3080	Length:	748	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	184/812 - (22%)
Similarity:	281/812 - (34%)	Gaps:	218/812 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 IYQLKTTRQHS----GRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRR 136
            |..|.|...|.    |.::|...:..:.|.|.|        ...|:|            :.|.|.
  Rat    23 IQHLSTGHDHDDVDVGEQQKDISEINSAAGLNL--------FQGDIL------------LPRTRN 67

  Fly   137 AVTVRKERTWDYGVIPYEI-DTIFSGAHKALFKQAMRHWENF---TCIKFVERDPNLHANYIYFT 197
            |:.....| |. ..|||.: |.:...|..|:    :..:|.|   :|:.|...:.  .::||.|.
  Rat    68 ALRDPSSR-WK-PPIPYILADNLDLNAKGAI----LNAFEMFRLKSCVDFKPYEG--ESSYIIFQ 124

  Fly   198 VKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRG 262
             :..||.|.:|....| |.||||..|:...||.||:.|.:||.||.:|.|||.::.|....||..
  Rat   125 -QFSGCWSMVGDQHVG-QNISIGEGCDYKAIIEHEILHALGFFHEQSRTDRDDYVNIWWNEIMTD 187

  Fly   263 QEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGD 327
            .|:||:....:.:.....|||..|:|||...||:|:..:.||| ..||....: :|||...|..|
  Rat   188 YEHNFNTYDDKTITDLNTPYDYESLMHYGPFSFNKNETIPTIT-TKIPEFNAI-IGQRLDFSATD 250

  Fly   328 IVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGD----AGEDPSAESEFDASLT 388
            :.:.|.:|.|.   ||      |.:..|..:....:....:|:.|    ..||.|...:.|.:|.
  Rat   251 LTRLNRMYNCT---RT------HTLLDHCAFEKTNICGMIQGTRDDADWVHEDSSQPGQVDHTLV 306

  Fly   389 -NCEW--------RITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDG------YWHKSPLVRR- 437
             .|:.        ..:...||..:|..:.|:......|.|.:.::...      .|     |||
  Rat   307 GRCKAAGYFMYFNTSSGVTGEVALLESRILYPKRKQQCLQFFYKMTGSPSDRLLIW-----VRRD 366

  Fly   438 -ICGNVSGEVITTQT------SRMLLNYVNRNAAKGYR----GFKARFEVVCGG----DLKLTKD 487
             ..|||. ::...||      ....:.:|..|..|.:|    |.|.......||    |:.||:
  Rat   367 DNTGNVR-QLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFQGTKGDPGNSDGGIYLDDITLTE- 429

  Fly   488 QSIDSPNYPMDYMPDKECVWRI---------TAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGN 543
                        .|....||.|         |...:..|:.:|.:.|       .|.|
  Rat   430 ------------TPCPTGVWTIRNISQVLENTVKGDRLVSPRFYNSE-------GYGF------- 468

  Fly   544 HSDSRLIGRFCGDKLPPNIKTRSNQMYI-----RFVSDSSV---QKLGFSAALMLDVDECKFTDH 600
                       |..|.||.:..||..|:     .:..|:.|   ..:....|:|..:|:.....:
  Rat   469 -----------GVTLYPNGRITSNSGYLGLAFHLYSGDNDVILEWPVENEQAIMTILDQEPDARN 522

  Fly   601 GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLY--SPSYPDVYPNSKQCV 663
            ......:.|...||                        .::..|||:.  .|:...||.....|.
  Rat   523 RMSLSLMFTTSKYQ------------------------TSSAINGSVIWDRPTKVGVYDKDCDCF 563

  Fly   664 ----WEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRD---NRLKKIGIYCGHELP 721
                |......:|.:.:          |.::.|  .|.|||:...:|   .|..::.|.....:|
  Rat   564 RSIDWGWGQAISHQMLM----------RRNFLK--DDTLIIFVDFKDLTHLRQTEVPISSRSVIP 616

  Fly   722 ---------PVVNSEQSILRLEFYSDRTV-QRSGFVAKFVID--------------VDECSMNNG 762
                     |:...:..|..:|....|.: ||.....|..::              .|.|..|
  Rat   617 RGLLLQGQEPLALGDSRIAMMEESLPRRLDQRQPSRPKRSVENTGPMEDHNWPQYFRDPCDPN-- 679

  Fly   763 GCQHR--CRNTFGSYQCSCRNGYTLAENGHNC 792
            .||:.  |.|..|...|.|.:|:.....|..|
  Rat   680 PCQNEGTCVNVKGMASCRCVSGHAFFYTGERC 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	68/204 (33%)
		Astacin	144..339	CDD:279708	68/198 (34%)
		CUB	388..474	CDD:214483	22/112 (20%)
		CUB	478..586	CDD:278839	24/128 (19%)
		FXa_inhibition	595..630	CDD:291342	3/34 (9%)
		CUB	634..750	CDD:278839	25/134 (19%)
		FXa_inhibition	757..792	CDD:291342	11/36 (31%)
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Mep1a	NP_037275.1	ZnMc	32..260	CDD:294052	78/259 (30%)
		Astacin	75..261	CDD:279708	67/197 (34%)
		MAM	270..433	CDD:279023	35/181 (19%)
		MAM	270..432	CDD:99706	34/180 (19%)
		MATH	432..596	CDD:295307	39/224 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..668		4/26 (15%)
		EGF	676..710	CDD:278437	11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810