DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tld and Tll2

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_036034.1 Gene:Tll2 / 24087 MGIID:1346044 Length:1012 Species:Mus musculus


Alignment Length:890 Identity:415/890 - (46%)
Similarity:562/890 - (63%) Gaps:40/890 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 RRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFT 197
            |.|||.|.|.||.|..|||||.|...|:|..:|:|||||||||..||:.||||..  ..::|.|:
Mouse   143 RVRRATTSRTERIWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEKHTCVTFVERTD--EESFIVFS 205

  Fly   198 VKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRG 262
            .:.|||||::|:.|.|.|.||||:||:||||:.|||||.:||.|||.|.|||:|:.|.:.||..|
Mouse   206 YRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPG 270

  Fly   263 QEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGD 327
            |||||..:...||......||.:||||||:|:||:..:||||.|.....|....:|||.|||:||
Mouse   271 QEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQGD 335

  Fly   328 IVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEW 392
            |.||..||||.:||.|.|..:|:..:|.|   .||.                     .|.::|.|
Mouse   336 IAQARKLYKCPACGETLQDTTGNFSAPGF---PNGY---------------------PSYSHCVW 376

  Fly   393 RITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLN 457
            ||:.|.|||:||:...:.|..|..|..||:|||||||.|:||:.|.||:...|.:.:..||:.:.
Mouse   377 RISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKIPESLVSSDSRLWVE 441

  Fly   458 YVNRNAAKGYRGFKARFEVVCGGDLKLTKDQ-SIDSPNYPMDYMPDKECVWRITAPDNHQVALKF 521
            :.:.:::.| :||.|.:|.:||||  :|||. .|.|||||.||.|.||||||||.||...|.|.|
Mouse   442 FRSSSSSLG-KGFFAVYEAMCGGD--ITKDAGQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTF 503

  Fly   522 QSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSA 586
            ||||:|:||.||||::|||||...||.|||.|||.:.|..:|:.:|:::::||||.|:.|.||:|
Mouse   504 QSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSANRLWVKFVSDGSINKAGFAA 568

  Fly   587 ALMLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSP 650
            ....:||||.:.|| ||:..|:||||||.|.|..||||.|:.||||.||||.:  ||.||::.||
Mouse   569 NFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAADKKTCEVACGGFI--TKLNGTITSP 631

  Fly   651 SYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIY 715
            .:|..||.:|.|||:||||..:.:.|.|..|:|||.    ..|.||::.:.|.:..: .|..|.:
Mouse   632 GWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGN----DVCKYDFVEVRSGLSPD-AKLHGKF 691

  Fly   716 CGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCR 780
            ||.|.|.|:.|:.:.:|:||.||.||.:.||.|.|..|.|||:.:|||||..|.||||||.|.||
Mouse   692 CGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQQECVNTFGSYLCRCR 756

  Fly   781 NGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVE 845
            |||.|.||||:|.|..|.::|:::.|.|.|||:|:.||....|.|:..:..|||:::||.:||:|
Mouse   757 NGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIE 821

  Fly   846 SHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSEC 910
            .||||.||::.:|||....:..||.:||.::|..|:|:.:.:|:...:||.:|||||:|...:||
Mouse   822 QHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVATGSSLFLRFYSDASVQRKGFQAVHSTEC 886

  Fly   911 GGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEIT 975
            ||.|:|...::..|||.::|...|.....|||.|.|:....|::.|..||:|....|.||::| .
Mouse   887 GGRLKAEVQTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFME-A 950

  Fly   976 EEGYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGF 1019
            .:||..:... |||||......|.|..|:|::||.||::.:.:||
Mouse   951 YDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFHTDDTINKKGF 995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 108/200 (54%)
CUB 388..474 CDD:214483 35/85 (41%)
CUB 478..586 CDD:395345 64/108 (59%)
FXa_inhibition 595..630 CDD:464251 20/35 (57%)
CUB 634..750 CDD:395345 48/115 (42%)
FXa_inhibition 757..792 CDD:464251 24/34 (71%)
CUB 797..906 CDD:395345 45/108 (42%)
CUB 910..1023 CDD:395345 41/111 (37%)
Tll2NP_036034.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..135
ZnMc_BMP1_TLD 147..346 CDD:239808 108/200 (54%)
CUB 348..457 CDD:395345 45/133 (34%)
CUB 461..570 CDD:395345 65/110 (59%)
FXa_inhibition 577..613 CDD:464251 20/35 (57%)
CUB 617..726 CDD:395345 48/115 (42%)
FXa_inhibition 733..768 CDD:464251 24/34 (71%)
CUB 773..882 CDD:395345 45/108 (42%)
CUB 886..999 CDD:395345 41/111 (37%)
Blue background indicates that the domain is not in the aligned region.

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