Protein Alignment tld and Tll1

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_033416.2
• Gene: Tll1 / 21892
• MGIID: 106923
• Length: 1013
• Species: Mus musculus
• Alignment Length: 964
• Identity: 426/964 - (44%)
• Similarity: 590/964 - (61%)
• Gaps: 60/964 - (6%)

  Fly    69 PKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQR 133
            ||: :..:|||....:..|...:|::..:.||     ||.|           |.....|..|
Mouse   102 PKK-RGALYQLIERIRRIGSGLEQNNTMKGKA-----PPKL-----------SEQSEKNRVP--- 146

  Fly   134 RRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTV 198
              ||.|.|.||.|..|||||.|...|:|:.:|:|||||||||..||:.|.||..  ..:||.||.
Mouse   147 --RAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSD--EESYIVFTY 207

  Fly   199 KNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQ 263
            :.|||||::|:.|||.|.||||:||:||||::|||||.|||.|||.|.|||.|:.|.:.||..||
Mouse   208 RPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQ 272

  Fly   264 EYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDI 328
            ||||..:.|.||:.....||.:||||||:|:||:..:||||.|.....|....:|||.|||:|||
Mouse   273 EYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDI 337

  Fly   329 VQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWR 393
            .||..||:|.:||.|.|::||::.||.|   .||.                     .|.|:|.||
Mouse   338 AQARKLYRCPACGETLQESSGNLSSPGF---PNGY---------------------PSYTHCIWR 378

  Fly   394 ITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNY 458
            ::.|.|||::|:...:.|..|..|..||:|:|||||.||||:.|.||:....|:|:..|||.:.:
Mouse   379 VSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEF 443

  Fly   459 VNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQS 523
            .:.:...| :||.|.:|.:|||:::..:.| |.|||||.||.|.|||||:|...:.:.|.|.||:
Mouse   444 RSSSNWVG-KGFAAVYEAICGGEIRKNEGQ-IQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQA 506

  Fly   524 FELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAAL 588
            ||:|:||.||||.:|:|||...:|.|||||||...|.:|::.||.::::||||.:|.|.||:|..
Mouse   507 FEIERHDSCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571

  Fly   589 MLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSY 652
            ..:.|||...|. ||:..|:||||||||.|..||||..:.::||.||||::  ||.||::.:|.:
Mouse   572 FKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLL--TKLNGTITTPGW 634

  Fly   653 PDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCG 717
            |..||.:|.|||:|:||..:.:.:.|..|:|||...    |.|||:.|:|.: .:..|..|.:||
Mouse   635 PKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEV----CKYDYVEIWSGL-SSESKLHGKFCG 694

  Fly   718 HELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNG 782
            .::|.|:.|..:.:|:||.||.||.:.||.|.|..|.||||.:||||||.|.||.|||.|.||||
Mouse   695 ADIPEVMTSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYTCQCRNG 759

  Fly   783 YTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESH 847
            :.|.||.|:|.|..|:.:|.:..|::.|||:|:.||....|.|....:.||||.|.|::||||.|
Mouse   760 FVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWVISAIPGHRITLAFNEFEVEQH 824

  Fly   848 QECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGG 912
            |||.||::.|:||.:|.|..||..||.:.|..::|:.||||:...:||.:|||||:||..:||||
Mouse   825 QECAYDHLEIFDGETEKSPILGRLCGSKIPDPLMATGNEMFIRFISDASVQRKGFQATHSTECGG 889

  Fly   913 YLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEE 977
            .|:|.:..:..|||.::|...|...:.|:|.:.::..|.:::.|..||:|....|.|||:|:. :
Mouse   890 RLKAESKPRDLYSHAQFGDNNYPGQLDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEVF-D 953

  Fly   978 GYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPE 1030
            |.|...:. |||||...|..|.|..|..|:.|.||::.:.:||.|.:.::..||
Mouse   954 GLSSKAVGLGRFCGSGPPEEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPE 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	111/200 (56%)
		CUB	388..474	CDD:214483	36/85 (42%)
		CUB	478..586	CDD:395345	56/107 (52%)
		FXa_inhibition	595..630	CDD:464251	18/35 (51%)
		CUB	634..750	CDD:395345	46/115 (40%)
		FXa_inhibition	757..792	CDD:464251	23/34 (68%)
		CUB	797..906	CDD:395345	50/108 (46%)
		CUB	910..1023	CDD:395345	40/113 (35%)
Tll1	NP_033416.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..150		11/46 (24%)
		ZnMc_BMP1_TLD	148..347	CDD:239808	111/200 (56%)
		CUB	349..458	CDD:395345	48/133 (36%)
		CUB	462..571	CDD:395345	57/109 (52%)
		FXa_inhibition	582..614	CDD:464251	17/31 (55%)
		CUB	618..727	CDD:395345	46/115 (40%)
		FXa_inhibition	734..769	CDD:464251	23/34 (68%)
		CUB	774..883	CDD:395345	50/108 (46%)
		CUB	887..1000	CDD:395345	40/113 (35%)