DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and Y19D10A.6

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_503652.3	Gene:	Y19D10A.6 / 189484	WormBaseID:	WBGene00021221	Length:	272	Species:	Caenorhabditis elegans

Alignment Length:	278	Identity:	73/278 - (26%)
Similarity:	112/278 - (40%)	Gaps:	94/278 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 SQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQ---PIQRRRRAVTVR----KERTWDYGVIPY 153
            |:|....:||               :..|:..|.   |: |::|.:.:.    ....|....:||
Worm    19 SENNILTKLP---------------TFEPSKYGHINIPL-RKKRGIALHPLQWASYLWPNAEVPY 67

  Fly   154 EIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYI----YFTVKNCGCCSFLGK----- 209
            :|.|.::...|::...||..::|.||::|..|... ..:|:    ||.|:.  |.|::|:
Worm    68 DIATHYTSTEKSIILSAMEAFKNVTCVRFRPRAAT-DKHYLQINKYFNVER--CFSYIGRQSSRT 129

  Fly   210 --------------------NGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVI 254
                                .||||            ||::|||.|.:||:|||.|.|||:.||
Worm   130 LFGTPEGNVETRMRLDPACLRGNGR------------GIVMHELMHILGFYHEHQRDDRDRRIV- 181

  Fly   255 NKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQ 319
              |:.:   .|||.:....:. |.:..||.||||||   :|...|:                 .:
Worm   182 --GSAV---HYNFKIYRRAKT-LYMGAYDANSIMHY---NFQNLPW-----------------QR 220

  Fly   320 RKRLSRGDIVQANLLYKC 337
            |...|..||:..|..|||
Worm   221 RDHFSTSDIININTFYKC 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	64/234 (27%)
		Astacin	144..339	CDD:279708	64/223 (29%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Y19D10A.6	NP_503652.3	Astacin	58..240	CDD:279708	64/223 (29%)
Y19D10A.6	NP_503652.3	ZnMc	62..236	CDD:294052	60/215 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770