DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-5

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_492616.1	Gene:	nas-5 / 188819	WormBaseID:	WBGene00003524	Length:	360	Species:	Caenorhabditis elegans

Alignment Length:	302	Identity:	84/302 - (27%)
Similarity:	124/302 - (41%)	Gaps:	60/302 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PIQRR----RRAVTVRKERTW--------DYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKF 182
            ||:.|    |.|:.......|        :| :|||.|...:....:...|.||....|.|||:.
Worm    51 PIRERRPIFRNALLSNSPLRWSKMQDLDGNY-LIPYVISGNYDTVERDTIKTAMEKIANNTCIRL 114

  Fly   183 VER--DPNLHANYIYFTVKN---CGCCSFLGKNGNGRQPISIGRN----CEKFGIIIHELGHTIG 238
            :.|  .|:      |..:.|   .||.:.:|: ..|:..:.:..|    |.:...:||||.|.||
Worm   115 IPRTNQPD------YAEINNKKGQGCYASIGR-FPGKNVVMLESNDDQSCIQEDTVIHELFHVIG 172

  Fly   239 FHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDT 303
            ..|||.|.|||..|.:...||...|...|:.||..:.....:|||.||:|||.:|:|:|...:..
Worm   173 LWHEHMRADRDAFINVLYKNIEPAQYPQFEKLSSRDATTYSVPYDYNSVMHYDENAFAKPGKISM 237

  Fly   304 ITP-------IGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGN 361
            :|.       ||.|          |..|..|..:...:|.|:.|   ..|:...||....|...|
Worm   238 MTKDSKFQKVIGHP----------KDASSNDYKKVCAIYHCSKC---MHQDFQQIVEQEHIELNN 289

  Fly   362 GVLSEFE-GSGDAGED-----PSAESEFDASLTNCEWRITAT 397
            .:::... ..||:..|     |..:|.   .:.||  ::.||
Worm   290 PIITNAPVQQGDSCTDRLGICPMLKSR---EMLNC--KVMAT 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	64/224 (29%)
		Astacin	144..339	CDD:279708	64/218 (29%)
		CUB	388..474	CDD:214483	4/10 (40%)
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-5	NP_492616.1	ZnMc_astacin_like	80..266	CDD:239807	61/203 (30%)
nas-5	NP_492616.1	Astacin	83..269	CDD:279708	61/202 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810