DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-21

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_505907.2	Gene:	nas-21 / 188422	WormBaseID:	WBGene00003540	Length:	380	Species:	Caenorhabditis elegans

Alignment Length:	423	Identity:	103/423 - (24%)
Similarity:	162/423 - (38%)	Gaps:	98/423 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LNGQPIQRR-----RRAVTVRKERTWDYGVIPYEID-TIFSGAHKALFKQAMRHWENFTCIKFVE 184
            :.|.|..:|     |:|:.:..|..|..|.|.|..| ..|....:|...:||....|.|||||..
Worm    31 VGGSPETKRLERSKRQALRMDNEPRWPRGTINYFFDEQRFDENSRATVLRAMEKISNHTCIKFSP 95

  Fly   185 RDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRD 249
            :|..:...    .|.:.||.:.:|:.|..:|.:|...:|...| ...||.|.|||.|.|.|.|||
Worm    96 KDARIKLR----IVSDKGCQAAIGRVGGDQQYLSFPTSCYSVG-SASELIHVIGFLHSHQRADRD 155

  Fly   250 KHIVINKGNIMRGQEYN--FDVLSPEEV--DLPLLPYDLNSIMHY--AKNSF--SKSPYLDTITP 306
            :::.:|    ::....|  |..:..::.  ...::|||..|||.|  :.|.:  ..|.|..|:
Worm   156 EYLKLN----LQPWRLNDWFQTMQYKKYLDQWWIVPYDYGSIMQYHDSDNEYGPKNSKYFRTM-- 214

  Fly   307 IGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQ---QNSGHIVSPHFIYSGNGVLSEFE 368
                 |:.:.       |..|.:..|..|:| ||....|   :|.|        |...|..||.
Worm   215 -----GSQIP-------SYFDYLMINEYYQC-SCEGEEQINCKNRG--------YPNPGNCSEC- 257

  Fly   369 GSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSP 433
                  ..|...||        ||:....|.:...:.||....:...|....||.|      .:|
Worm   258 ------NCPLESSE--------EWKNITLNLDAGYMSLQNGTKLHQIDFVFRYLSI------SAP 302

  Fly   434 LVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGG-DLKLTKDQSIDSPNYPM 497
            ..:.|  .|....||                    |.:..:....|| ::|..:|:.:.||.  :
Worm   303 ANKTI--EVDIREIT--------------------GVECNYGCYIGGIEVKTHEDRRMTSPR--L 343

  Fly   498 DYMPDKECVWRITAPDNHQVALKFQSFELEKHD 530
            ....|.| :::  :.:|..:.:.|.|..|:|::
Worm   344 CCKNDNE-IYK--SRNNPTIVMAFNSEGLDKYN 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	58/209 (28%)
		Astacin	144..339	CDD:279708	57/203 (28%)
		CUB	388..474	CDD:214483	15/85 (18%)
		CUB	478..586	CDD:278839	13/54 (24%)
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-21	NP_505907.2	ZnMc	52..192	CDD:214576	44/148 (30%)
nas-21	NP_505907.2	ZnMc_astacin_like	59..231	CDD:239807	54/194 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810