DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-20

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_505906.2	Gene:	nas-20 / 188420	WormBaseID:	WBGene00003539	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	87/382 - (22%)
Similarity:	144/382 - (37%)	Gaps:	112/382 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LNGQPIQRRRRAVTVRKERTWD-------YGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFV 183
            |:.:.|.|.:|. .:|....|:       :..:|.|:        :|:|:.|:.:.||.||:||
Worm    19 LSDRHITRDKRQ-AMRDYAKWENNKMSLFFYNLPLEM--------QAMFRDAINYLENHTCLKF- 73

  Fly   184 ERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDR 248
              :.|.:|.......|..||.|..|.:....|.:::..||..||..:||:.|.:|..|..||.||
Worm    74 --EYNENAETAVRIRKGNGCYSLYGMHAGEVQDLTLDYNCASFGTAVHEIMHALGIAHGQARSDR 136

  Fly   249 DKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGT 313
            |.:::::..|...|.|...:          |:|:|..|:|.||::     |:.|...|  |.|..
Worm   137 DDYLIVDSTNSNDGIENTEN----------LVPFDYGSVMLYARD-----PHSDKRIP--IDPEY 184

  Fly   314 HLELGQRKRLSRGDIVQANLLYKC--------ASCGRTYQQN-------------SGHIVSPHFI 357
            :..:|. .|::..|:|..|..|.|        ..|.....||             :|.:...|
Worm   185 NFTMGS-LRVAFYDMVLLNKFYGCNCDNHPRKLDCKNGGYQNPANCEECLCTDGFNGQLCDQH-- 246

  Fly   358 YSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWR---------------ITATNGEKVILHLQ 407
             .|..||             .|:.|:|||.....:|               :||..|..:.:.:.
Worm   247 -EGVYVL-------------EAKKEWDASGVRNNYRKGIETNTMPEYTYFALTAPEGSTIEVRIT 297

  Fly   408 QLH-LMSSDDCTQDYLEIR----------------DGYWHK------SPLVRRICGN 441
            :|. ......|..:.:|::                |..|:|      :|.:....||
Worm   298 KLSGFFCQHTCDYNGVELKYKTDRRIVSPLVCCDNDNLWNKTRSSTNNPFIIAKYGN 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	57/215 (27%)
		Astacin	144..339	CDD:279708	56/209 (27%)
		CUB	388..474	CDD:214483	13/92 (14%)
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-20	NP_505906.2	Astacin	36..209	CDD:279708	56/201 (28%)
nas-20	NP_505906.2	ZnMc	49..205	CDD:294052	53/184 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810