DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-3

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_505445.2	Gene:	nas-3 / 187045	WormBaseID:	WBGene00003522	Length:	292	Species:	Caenorhabditis elegans

Alignment Length:	302	Identity:	73/302 - (24%)
Similarity:	116/302 - (38%)	Gaps:	82/302 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FFGILDSSLVPPKEP-KDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHS 121
            ||.:|..:.....|| |||...:|.               ..|.::..||    .||.:.|
Worm     7 FFSLLALTASKVSEPEKDDEIAVKI---------------PTKRSVSEPP----KDDDIAV---- 48

  Fly   122 HSPTLNGQPIQRRRRAVTVR----KERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKF 182
                   :...|::|.:.:.    :...|....:||:|.:.::...:.:...||..:.:.||::|
Worm    49 -------KIPMRKKRGIAIHPWQWESHLWPNAEVPYDIASHYTATERGIILSAMEAFRDVTCVRF 106

  Fly   183 VERDPN----LHANYIYFTVKNCGCCSFLG----------KNGNGRQPISIGRNCEKF---GIII 230
            ..|...    |..|..|...:   |.|::|          ::|.....:.:..:|..:   |.::
Worm   107 RPRRSTDKHYLQINKHYQLER---CFSYIGRQSSRWLFGTRDGKVETRMKLDPSCLLYNGRGTVM 168

  Fly   231 HELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSF 295
            |||.|.:||:|||.|.|||:.|    |.  ....|||.:....: ...:..||.||||||   :|
Worm   169 HELMHILGFYHEHQRDDRDRRI----GG--SASHYNFKIYQRAK-SYYMGGYDANSIMHY---NF 223

  Fly   296 SKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKC 337
            ...|:                 .:|...|..||...|.||||
Worm   224 GSVPW-----------------QKRDYFSPSDIRNINTLYKC 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	56/222 (25%)
		Astacin	144..339	CDD:279708	56/211 (27%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-3	NP_505445.2	Astacin	69..250	CDD:279708	56/210 (27%)
nas-3	NP_505445.2	ZnMc	72..246	CDD:294052	51/203 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770