DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and nas-17

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_505892.1	Gene:	nas-17 / 186923	WormBaseID:	WBGene00003536	Length:	448	Species:	Caenorhabditis elegans

Alignment Length:	442	Identity:	96/442 - (21%)
Similarity:	156/442 - (35%)	Gaps:	134/442 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DDAVD---VLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRH 173
            |..||   :|..:....|||...:.:|:...:.|:  |....:.|..:..|:...:.|...||.|
Worm    55 DGIVDGDIMLTEAQLRILNGTAKRSKRQITKIWKK--WPDAKVFYYYENEFTSLKRELMSYAMAH 117

  Fly   174 WENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIG 238
            ..:.||:||  ::.|...|.|.|| ...||.|::|.|| |.|.:..|..|..||..:||:.|::|
Worm   118 ISSNTCVKF--QESNSATNRIRFT-NTGGCASYIGMNG-GEQTLWFGDGCLIFGTAVHEIMHSLG 178

  Fly   239 FHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYL-- 301
            ..|.|:|.|||..:.::..::......|.: ...|:.....:|::..|.|.|..|:|.:...:
Worm   179 LFHTHSRFDRDNFLSVSYKDVPENMVGNLE-KETEQTTYNAVPFEYGSTMLYRYNTFGEGTLVSK 242

  Fly   302 --DTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVL 364
              |....:|:           :|:|..|:|..|:.|   |||
Worm   243 NEDYQKTMGL-----------RRVSFYDLVNINVRY---SCG----------------------- 270

  Fly   365 SEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYW 429
                                     |...:|..||                           ||.
Worm   271 -------------------------CAKSLTCENG---------------------------GYT 283

  Fly   430 HKSPLVRRIC-----GNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS 489
            :.|.....:|     |.:..|..:        |.:...|...::|:...|..          ..|
Worm   284 NPSNCATCVCPTGFAGTLCNEAPS--------NTIKLTAESYWKGYWVNFGY----------STS 330

  Fly   490 IDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFE-LEKHDGCAYDFVEIR 540
            |.:.||.:.|:      | ||||.:..:.:|..... .....||.|:.||::
Worm   331 IQTTNYYLAYL------W-ITAPADKTIEVKIMDLSGFTCSYGCNYNGVEVK 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	55/204 (27%)
		Astacin	144..339	CDD:279708	54/198 (27%)
		CUB	388..474	CDD:214483	13/90 (14%)
		CUB	478..586	CDD:278839	16/64 (25%)
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-17	NP_505892.1	Astacin	88..271	CDD:279708	58/251 (23%)
nas-17	NP_505892.1	ZnMc_astacin_like	92..267	CDD:239807	52/190 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810