DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tld and nas-31

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001023994.1	Gene:	nas-31 / 186493	WormBaseID:	WBGene00003549	Length:	611	Species:	Caenorhabditis elegans

Alignment Length:	657	Identity:	158/657 - (24%)
Similarity:	227/657 - (34%)	Gaps:	196/657 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 YQLKTTRQHSGRRRKQSHKSQ----------------NKAA----LRLPPPFLWTDDAVDVLQHS 121
            ||...|.|.:|...:|....:                ||||    :......:.|||.:..:..:
Worm    80 YQNAGTNQENGATEQQKPLREKPRDRVKMEGDTLHQVNKAAGLNDILYQGDMVLTDDQIATILEA 144

  Fly   122 HSPTLNGQPIQRRRRAVTVR--KERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVE 184
            ...|......:.||:|...|  ...||...|..|...|......|| |:||:..|:|.|||..::
Worm   145 RDETTVSTASRARRQAYRDRYYPSTTWGSSVYYYYDRTATPKIVKA-FEQAVAFWQNVTCINIMQ 208

  Fly   185 RDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRD 249
            ....::...::   |..||.|::|:. :|.|.:|:|..||:||...|||||.:||.|..:|.|||
Worm   209 SSTAINRIRVF---KGQGCYSYVGRI-SGVQDLSLGTGCEEFGTAAHELGHALGFFHTQSRYDRD 269

  Fly   250 KHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSK----------SPYLDTI 304
            .:|.||..||.......||..:........:|||..|||.|...|.|.          :.|.||:
Worm   270 NYISINYANIDPSYVEQFDKETSNTNFNYGMPYDYGSIMQYGATSASSNDKATMIARDTEYQDTM 334

  Fly   305 TPIGIPPGTHLELGQRKRLSRGDIVQANLLYKC---ASCGRTYQQNSGHIVSPHFIYSGNGVLSE 366
                   |:..       :...||...|..|||   .....:.|..:|...||.
Worm   335 -------GSDF-------VGFYDISMMNEHYKCKELCPAASSAQCKNGGFPSPR----------- 374

  Fly   367 FEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHK 431
                                  ||...| ..:|...||            |.|           :
Worm   375 ----------------------NCAICI-CPSGYGGIL------------CDQ-----------R 393

  Fly   432 SPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYP 496
            .|    .||:   .|..|.|.:.|.|.:                   |..|...:|      |:.
Worm   394 PP----GCGD---SVTATTTWQTLTNTI-------------------GDGLPTLRD------NHT 426

  Fly   497 MDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIG-RFCGDKLPP 560
            |       |.:.:.||||..|.::.........|||.:..|||:  .|.|.:|.| |:| .....
Worm   427 M-------CNYWVKAPDNQAVEIRISGLTTVTIDGCIFGGVEIK--THKDQKLTGYRYC-SSADQ 481

  Fly   561 NIKTRSNQ------MYIRFVSDSSVQKLGFSAAL-MLDVDECKFT----DHGCQHLCINTLGSYQ 614
            |...||..      ::.|:.|..:|  |.:.|.. .:||.....|    .:.||.|..|
Worm   482 NTVHRSTGSLVPIILFNRYASTKAV--LEYRAVTPSVDVSATYTTFAPIVNSCQDLHPN------ 538

  Fly   615 CG-------CRAGYELQANGK-TCEDACGGVVDATKSN---------GSLYSPSYPDVYP----- 657
            |.       ||: .::::|.| ||.|..........||         .:.|:....:.||
Worm   539 CDFYKFFGMCRS-KKIRSNCKFTCHDCNNNNASPFGSNFFNNNYNSFNNWYTNKNKNYYPYSNSN 602

  Fly   658 NSKQCVW 664
            |:|..:|
Worm   603 NNKPWMW 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	68/215 (32%)
		Astacin	144..339	CDD:279708	66/207 (32%)
		CUB	388..474	CDD:214483	16/85 (19%)
		CUB	478..586	CDD:278839	30/114 (26%)
		FXa_inhibition	595..630	CDD:291342	10/46 (22%)
		CUB	634..750	CDD:278839	8/45 (18%)
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-31	NP_001023994.1	Astacin	169..355	CDD:279708	66/204 (32%)
		ZnMc_astacin_like	175..351	CDD:239807	61/194 (31%)
		ShKT	532..564	CDD:214586	11/38 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910