DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and Pcolce

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_032814.2	Gene:	Pcolce / 18542	MGIID:	105099	Length:	468	Species:	Mus musculus

Alignment Length:	289	Identity:	83/289 - (28%)
Similarity:	136/289 - (47%)	Gaps:	43/289 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 AKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELE 527
            |:|......|...:||||  :|.:.. :.|..:|..|.|:|:|:|.||.|:...|:|.|:.|::|
Mouse    22 ARGQTPNYTRPVFLCGGD--VTGESGYVASEGFPNLYPPNKKCIWTITVPEGQTVSLSFRVFDME 84

  Fly   528 KHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDV 592
            .|..|.||.:|:..|:.:..:.:|||||...|..:....||:.:|..:|......||
Mouse    85 LHPSCRYDALEVFAGSGTSGQRLGRFCGTFRPAPVVAPGNQVTLRMTTDEGTGGRGF-------- 141

  Fly   593 DECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDV-Y 656
                                     ...|..:|...|....|||.::  |:.|:|.:|::|:. |
Mouse   142 -------------------------LLWYSGRATSGTEHQFCGGRME--KAQGTLTTPNWPESDY 179

  Fly   657 PNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELP 721
            |....|.|.::||.|..:.|.|..||:|..    |.|.||.:.:::....:..|::|.:||.:.|
Mouse   180 PPGISCSWHIIAPSNQVIMLTFGKFDVEPD----TYCRYDSVSVFNGAVSDDSKRLGKFCGDKAP 240

  Fly   722 PVVNSEQSILRLEFYSDRTVQRSGFVAKF 750
            ..::||.:.|.::|.||.:|...||.|.:
Mouse   241 SPISSEGNELLVQFVSDLSVTADGFSASY 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483	2/9 (22%)
		CUB	478..586	CDD:278839	38/108 (35%)
		FXa_inhibition	595..630	CDD:291342	2/34 (6%)
		CUB	634..750	CDD:278839	39/116 (34%)
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
Pcolce	NP_032814.2	CUB	36..146	CDD:238001	38/144 (26%)
		CUB	158..271	CDD:238001	39/118 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..338
		NTR_PCOLCE	334..460	CDD:239631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910