Protein Alignment tld and nas-24

DIOPT Version :10

• Sequence 1: NP_524487.2
• Gene: tld / 42945
• FlyBaseID: FBgn0003719
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_506409.2
• Gene: nas-24 / 184744
• WormBaseID: WBGene00003543
• Length: 396
• Species: Caenorhabditis elegans
• Alignment Length: 474
• Identity: 100/474 - (21%)
• Similarity: 148/474 - (31%)
• Gaps: 173/474 - (36%)

  Fly   108 FLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIP-YEIDTIFSGAHKALFKQAM 171
            ||.:..|...|...:...:.|....:|.:....|....|..|.|. |..|.  :.:.|...|.|:
 Worm    12 FLLSSYAYCGLSRFNEHDIEGGDSYKRVKREFERLGSKWLGGTINYYYADN--NNSVKEKVKSAI 74

  Fly   172 RHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGN-----GRQPISIGRNCEKFGIIIH 231
            .:..|.|||||.| ||........||.:...|.|.:|..|.     |...:..|. |...|.|:|
 Worm    75 AYIANHTCIKFNE-DPTHWQRLKIFTSELSHCRSTIGAPGTRSGSAGELSMETGW-CANIGSIVH 137

  Fly   232 ELGHTIGFHHEHARGDRDKHIVINK---------------------GNIMRGQEYNFDVLSPEEV 275
            |..|::|.:|||.|.|||..:.:..                     |:||.....|:.|...|
 Worm   138 EFSHSLGRYHEHTRPDRDNSLKVTSTDYEARPRPWGMTTMYGPFEHGSIMMYHSSNYGVGKME-- 200

  Fly   276 DLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASC 340
                 |||    |.| ||:                      :|.| |::..|:.:.|..|.| .|
 Worm   201 -----PYD----MEY-KNT----------------------MGSR-RVTFYDMYKINQYYGC-GC 231

  Fly   341 GRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILH 405
            ....:..:|...||.                            |.|..||.......
 Worm   232 STQLECKNGGYTSPS----------------------------DCSRCNCPKGFFGK-------- 260

  Fly   406 LQQLHLMSSDDCTQDYLEIRDGY--WHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYR 468
                  :.::...||..|::..|  |                    ||..:..||.....:.
 Worm   261 ------LCNERRQQDSYELKATYGRW--------------------QTQTISFNYKPEPVSD--- 296

  Fly   469 GFKARFEVVCG---GDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHD 530
            ||.:.|..:.|   ..:::|           |:.:.:..|    ||
 Worm   297 GFYSTFVYITGEANSTIEIT-----------MEGLENVIC----TA------------------- 327

  Fly   531 GCAYDFVEIRDGNHSDSRL 549
            ||.::.|||:  :..|||:
 Worm   328 GCTWNGVEIK--SREDSRI 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	59/227 (26%)
		CUB	388..474	CDD:214483	13/87 (15%)
		CUB	478..586	CDD:395345	14/75 (19%)
		FXa_inhibition	595..630	CDD:464251
		CUB	634..750	CDD:395345
		FXa_inhibition	757..792	CDD:464251
		CUB	797..906	CDD:395345
		CUB	910..1023	CDD:395345
nas-24	NP_506409.2	Astacin	49..231	CDD:426242	59/221 (27%)