DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and clec-7

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_504865.1 Gene:clec-7 / 184314 WormBaseID:WBGene00017364 Length:417 Species:Caenorhabditis elegans


Alignment Length:457 Identity:102/457 - (22%)
Similarity:161/457 - (35%) Gaps:127/457 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   502 DKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRL---------IGRFCGDK 557
            :.:|:...|.|.||..|.|    ...|: |.....|:..:.||:.|..         ||.:|...
 Worm    33 NNKCLKLFTTPANHSAAEK----TCRKY-GATLVTVKNENDNHAISTFAGTSASLLWIGLYCFGN 92

  Fly   558 LPPNI----KTRSNQMYIRFVSDSSVQKLGFSAALMLDVDEC-----------KFTDHGCQ---- 603
            .|...    .|.|..:|..|.|       ||.   ::|:.:|           |:....|.    
 Worm    93 DPSKCLWDDSTGSADVYDNFAS-------GFP---LVDIGKCVYYSVQGALTGKWLTENCDLSSK 147

  Fly   604 -HLC-INTLGSYQC-----GCRAGYELQAN----GKTCEDACGGVVDATKSNGSLYSPSYPDVYP 657
             .:| :.|..|..|     |....|..:|:    ..|||..||.:.....:|.:.|..:....||
 Worm   148 AFMCELPTTFSDSCIYNYNGYCYDYYAEASFVVAQNTCEQFCGDLATIHTANENRYILTVAQHYP 212

  Fly   658 NSK----QCVWEVVAPPNHAVF-------LNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKK 711
            :|.    ...|     |...|:       ..:.:.||.|.|      ..|.:::.::        
 Worm   213 SSTIVRIGATW-----PASNVYQWVDGLPWEYKNIDLTGPR------GGDCMVMSTR-------- 258

  Fly   712 IGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQ 776
                     ||     ..:....::.........|:.|          ...|.|  |..|..|..
 Worm   259 ---------PP-----SPVAAGYWFGASCTDERNFICK----------RPAGLQ--CVGTPPSVT 297

  Fly   777 CSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHD 841
            .|     .:.:|...|..|.     ..:.||:.|||:|.:|..|.:|.:...|:..:.|.|.|..
 Worm   298 IS-----PIQDNPSFCNSTN-----LLAPGVVTSPNFPRNYNNNAFCTYQLSTLGSYNILLRFAP 352

  Fly   842 FEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATF 906
            |.:.:.     |||.:|||.|.:|..:|.|.|...|:::|:|:|.:.:|...:.|.|  ||.|.:
 Worm   353 FSLGTS-----DYVIVYDGESASSPVIGNYSGTLVPFSLISSSNNLLVVFNGNTGGQ--GFSARY 410

  Fly   907 VS 908
            .|
 Worm   411 TS 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808
CUB 388..474 CDD:214483
CUB 478..586 CDD:395345 24/96 (25%)
FXa_inhibition 595..630 CDD:464251 10/60 (17%)
CUB 634..750 CDD:395345 18/126 (14%)
FXa_inhibition 757..792 CDD:464251 7/34 (21%)
CUB 797..906 CDD:395345 35/108 (32%)
CUB 910..1023 CDD:395345
clec-7NP_504865.1 CLECT 25..152 CDD:214480 28/133 (21%)
CLECT 165..282 CDD:214480 24/149 (16%)
CUB 308..412 CDD:238001 37/115 (32%)
Blue background indicates that the domain is not in the aligned region.

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