DRSC/TRiP Functional Genomics Resources

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Protein Alignment tld and clec-6

DIOPT Version :10

Sequence 1:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_498023.1 Gene:clec-6 / 183242 WormBaseID:WBGene00016451 Length:407 Species:Caenorhabditis elegans


Alignment Length:463 Identity:100/463 - (21%)
Similarity:155/463 - (33%) Gaps:144/463 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   502 DKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRL---------IGRFCGD- 556
            :.:|:...:.|..|. |.|.:..|.    |.....|:....|:|.|::         ||.:|.| 
 Worm    31 NNKCLRLFSTPLGHS-ASKSKCMEY----GATLVTVKNAIENNSVSKIAASSSSSLWIGLYCFDS 90

  Fly   557 ---KLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHL---------CINT 609
               |...:..|.|.:||..|.|       ||.   .:|:.:|.:  |..|..         |...
 Worm    91 DVTKCMWDDSTGSAEMYNSFAS-------GFP---HVDIGKCVY--HFTQGFLGGKWLNGDCDTE 143

  Fly   610 LGSYQC--------GCRAGYELQANGK---------------TCEDACGGVVDATKSNGSLY--- 648
            ..::.|        .|...|    ||.               .||..||.:.....||.:.|   
 Worm   144 TRAFVCELTETLEDSCEYNY----NGHCYSFHQPATFAQAQVICEQECGNLASIHSSNENRYLSS 204

  Fly   649 ---SPSYPDVY-----PNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMR 705
               |.|..:.|     |::....|                  |:|:...|               
 Worm   205 IISSLSNKNYYIGASWPSTSVLTW------------------LDGSTSDY--------------- 236

  Fly   706 DNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRN 770
                ..|.....||....:.|.|.    ::.|........||                    |:.
 Worm   237 ----NNISPSSAHEGNCALLSSQE----QWLSSPCTSSQPFV--------------------CKR 273

  Fly   771 TFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRI 835
            :.||...|.....|:.....|  .:.|...:..:.|.:.|||:|.:|..|.:|.:|..|:..:|:
 Worm   274 SVGSQCFSTPPLVTITPTPPN--PSSCNSTLLMAPGKITSPNFPSNYGNNQFCSYHLSTLGSYRV 336

  Fly   836 QLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRK 900
            .|.|..|..    |..:|:|.:|||.|.:|..:|.|.|.:.|:|:.::.|.||:...:|.....:
 Worm   337 ALYFLTFTT----EFFFDFVVVYDGDSASSPKMGNYSGSKNPFALTSTGNNMFVTFKSDHSNTFQ 397

  Fly   901 GFKATFVS 908
            ||.|.|.|
 Worm   398 GFDARFQS 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808
CUB 388..474 CDD:214483
CUB 478..586 CDD:395345 24/96 (25%)
FXa_inhibition 595..630 CDD:464251 9/66 (14%)
CUB 634..750 CDD:395345 21/126 (17%)
FXa_inhibition 757..792 CDD:464251 5/34 (15%)
CUB 797..906 CDD:395345 35/108 (32%)
CUB 910..1023 CDD:395345
clec-6NP_498023.1 CLECT 23..150 CDD:214480 29/135 (21%)
CLECT 163..272 CDD:214480 26/173 (15%)
CUB 298..405 CDD:238001 36/110 (33%)
Blue background indicates that the domain is not in the aligned region.

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