DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-8

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_501114.2	Gene:	nas-8 / 183207	WormBaseID:	WBGene00003527	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	96/331 - (29%)
Similarity:	149/331 - (45%)	Gaps:	42/331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGIL--DSSLVPPKEPKDDIYQ 78
            :.:.:.:|.:.:..:..||..:.|  ||.|.....|... |||...|  |.:.:..|:.|:.
Worm    11 ITIFLSSLSLFVIIIPIYAAEKDL--LPPSTSSETFLTD-EDFLRPLNDDETFLTEKDFKNG--- 69

  Fly    79 LKTTRQH---SGRRRKQSHKS---QNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRA 137
            .|....|   .....||.:|.   :.|||.:|.|            ::|.|...||
Worm    70 EKLGEDHVPAGSILWKQVYKKGDIRGKAAWKLDP------------KNSESLRRNG--------- 113

  Fly   138 VTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCG 202
             .:...|.|..|.|||.|...::...:|:..::.:.:.:.||::||.|.. :..:|:|.. |..|
Worm   114 -VITGTRKWPNGRIPYVISNQYNDRERAVLARSFQAYHDKTCVRFVPRTA-VDNDYLYIG-KIDG 175

  Fly   203 CCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNF 267
            |.|.:|:.| |||.:|:...|.::...||||.|::||:|||.|.|||:||.|...||.|.....|
Worm   176 CYSDVGRAG-GRQELSLDNGCLQYDTAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQF 239

  Fly   268 DVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQAN 332
            ..:...|.......||..|||||...:|||:.:   .|.:.........:|.....|..||::.|
Worm   240 GKVDLAESSYYGQLYDYYSIMHYDSLAFSKNGF---ETMVAKQSEMTAVIGAAIDFSPIDILKMN 301

  Fly   333 LLYKCA 338
            |:|:|:
Worm   302 LMYQCS 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	66/200 (33%)
		Astacin	144..339	CDD:279708	67/195 (34%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-8	NP_501114.2	Astacin	119..308	CDD:279708	67/195 (34%)
		ZnMc_astacin_like	123..304	CDD:239807	63/186 (34%)
		ShK	337..372	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810