DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tld and nas-7

DIOPT Version :9

Sequence 1:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_495552.2	Gene:	nas-7 / 182368	WormBaseID:	WBGene00003526	Length:	382	Species:	Caenorhabditis elegans

Alignment Length:	294	Identity:	83/294 - (28%)
Similarity:	123/294 - (41%)	Gaps:	67/294 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DFDFKEQ--PEDFFG--ILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPF 108
            ||:|.::  .|:.||  |       |.|..:|.                      |:.:|||
Worm    42 DFEFADKLTREELFGKHI-------PVEVVNDF----------------------KSDIRLP--- 74

  Fly   109 LWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRH 173
                                   :|.:|....|..:.|....|||.|...:|...:||..:|::.
Worm    75 -----------------------RRHKRNGVSRAAKLWPNARIPYAISPHYSPHERALLAKAVKQ 116

  Fly   174 WENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIG 238
            :...|||:||.|... ..:|: |..|..||.|.:|:. :|.|.:|:...|.::..||||:.|.:|
Worm   117 YHEKTCIRFVPRQTG-EPDYL-FIGKVDGCFSEVGRT-SGVQVLSLDNGCMEYATIIHEMMHVVG 178

  Fly   239 FHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDT 303
            |:|||.|.|||..|.|...||.||....|..:...:......|||..||:||...:|||:.:
Worm   179 FYHEHERWDRDNFIDIIWQNIDRGALDQFGKVDLSKTSYYGQPYDYKSILHYDSLAFSKNGF--- 240

  Fly   304 ITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKC 337
              |..:|......:|..:..|..||.:.|.:|.|
Worm   241 --PTMLPKVKSATIGNARDFSDVDISKINRMYNC 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	67/201 (33%)
		Astacin	144..339	CDD:279708	66/194 (34%)
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839
		FXa_inhibition	757..792	CDD:291342
		CUB	797..906	CDD:278839
		CUB	910..1023	CDD:278839
nas-7	NP_495552.2	Astacin	87..274	CDD:279708	66/194 (34%)
		ZnMc_astacin_like	91..270	CDD:239807	63/186 (34%)
		ShK	347..382	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810